3105288-31-8
Chemical Structure
PROTAC STAT6 degrader-2
- CAS No.: 3105288-31-8
- Formula:C51H54F2N9O10PS
- Molecular Weight:1054.06
InChIKey: QPDSULYSBGIPNF-DYAQCJGLSA-N
SMILES: N#C[C@@H]1CN(C([C@H]2N(C([C@@H](NC(C3=CC4=C(C=CC(C(P(O)(O)=O)(F)F)=C4)S3)=O)CN(C(CC5CCN(C6=C(N(C)C(N7C8C(NC(CC8)=O)=O)=O)C7=CC=C6)CC5)=O)CC9)=O)[C@]9([H])CC2)=O)C[C@H]1C%10=CC=CC=C%10
Biological Activity: PROTAC STAT6 degrader-2 is a highly efficient PROTAC degrader targeting STAT6. PROTAC STAT6 degrader-2 has a DC50 value of 1-10 nM for STAT6 in human PBMC cells and a DC50 value of less than 100 nM for STAT6 in HEK293-HIBiT-STAT6 cells. PROTAC STAT6 degrader-2 can be used for STAT6-mediated diseases[1].
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PROTAC STAT6 degrader-2 | PROTAC STAT6 degrader-2 is a highly efficient PROTAC degrader targeting STAT6. PROTAC STAT6 degrader-2 has a DC50 value of 1-10 nM for STAT6 in human PBMC cells and a DC50 value of less than 100 nM for STAT6 in HEK293-HIBiT-STAT6 cells. PROTAC STAT6 degrader-2 can be used for STAT6-mediated diseases. | |||||||||||||||||||||
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Keywords
