417 Results for "

Sesquiterpene

" in MedChemExpress (MCE) Product Catalog:
Products (417)

417 Results for "Sesquiterpene" in MCE Product Catalog:

40
40 Publications Verification
Cat. No.: HY-N0141
CAS No.: 20554-84-1
Synonyms: (-)-Parthenolide
Parthenolide is a sesquiterpene lactone found in the medicinal herb Feverfew. Parthenolide exhibits anti-inflammatory activity by inhibiting NF-κB activation; also inhibits HDAC1 protein without affecting other class I/II HDACs.
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34
34 Cited Publications
Cat. No.: HY-B0094
CAS No.: 63968-64-9
Synonyms: Qinghaosu; NSC 369397
Artemisinin (Qinghaosu), a sesquiterpene lactone, is an anti-malarial agent isolated from the aerial parts of Artemisia annua L. plants . Artemisinin inhibits AKT signaling pathway by decreasing pAKT in a dose-dependent manner. Artemisinin reduces cancer cell proliferation, migration, invasion, tumorigenesis and metastasis and has neuroprotective effects .
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10
10 Cited Publications
Cat. No.: HY-N0847
CAS No.: 68370-47-8
Micheliolide is a sesquiterpene lactone with anti-cancer and anti-inflammatory effects, which is derived from Michelia compressa and Michelia champaca. Micheliolide can attenuate high glucose-stimulated NF-κB activation, IκBα degradation, and the expression of MCP-1, TGF-β1, and FN in mouse mesangial cells. Micheliolide inhibits LPS (HY-D1056)-induced activation of NF-κB and PI3K/Akt/p70S6K pathways to play an anti-inflammatory role. Micheliolide inhibits dextran sodium sulphate (DSS) (HY-116282)-induced inflammatory intestinal disease, colitis-associated cancer and rheumatic arthritis .
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6
6 Cited Publications
Cat. No.: HY-N0036
CAS No.: 553-21-9
Synonyms: (+)-Costunolide; Costus lactone
Costunolide ((+)-Costunolide) is a naturally occurring sesquiterpene lactone, with antioxidative, anti-inflammatory, antiallergic, bone remodeling, neuroprotective, hair growth promoting, anticancer, and antidiabetic properties. Costunolide can induce cell cycle arrest and apoptosis on breast cancer cells .
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6
6 Cited Publications
Cat. No.: HY-119970
CAS No.: 6754-13-8
Purity:  99.90%
Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factor NF-κB by directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit of NF-κB, thereby inhibits its DNA binding .
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5
5 Cited Publications
Cat. No.: HY-N0201
CAS No.: 73069-13-3
Atractylenolide I is a sesquiterpene derived from the rhizome of Atractylodes macrocephala, possesses diverse bioactivities, such as neuroprotective, anti-allergic, anti-inflammatory and anticancer properties. Atractylenolide I reduces protein levels of phosphorylated JAK2 and STAT3 in A375 cells, and acts as a TLR4-antagonizing agent.
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3
3 Cited Publications
Cat. No.: HY-N0207
CAS No.: 5986-55-0
Patchouli alcohol is a natural tricyclic sesquiterpene, exhibits anti-Helicobacter pylori, anti-inflammatory and antioxidant properties .
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3
3 Cited Publications
Cat. No.: HY-N0781
CAS No.: 728-61-0
Linderalactone is an important sesquiterpene lactone isolated from Lindera aggregata. Linderalactone inhibits cancer growth by modulating the expression of apoptosis-related proteins and inhibition of JAK/STAT signalling pathway. Linderalactone also inhibits the proliferation of the lung cancer A-549 cells with an IC50 of 15 µM .
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3
3 Cited Publications
Cat. No.: HY-N0591
CAS No.: 477-43-0
Synonyms: (-)-Dehydrocostus lactone; Epiligulyl oxide
Dehydrocostus Lactone ((-)-Dehydrocostus lactone) is a natural sesquiterpene that can be isolated from Saussurea lappa. Dehydrocostus Lactone has multiple activities such as anti-inflammatory, antibacterial, anti-tumor, and immunomodulatory effects. Dehydrocostus Lactone has an MIC of 2 µg/mL against Mycobacterium tuberculosis. Dehydrocostus Lactone can also inhibit the killing activity of cytotoxic T lymphocytes and induce apoptosis in tumor cells .
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2
2 Cited Publications
Cat. No.: HY-N0076
CAS No.: 33570-04-6
Synonyms: (-)-Bilobalide
Bilobalide, a sesquiterpene trilactone constituent of Ginkgo biloba, inhibits the NMDA-induced efflux of choline with an IC50 value of 2.3 μM. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SH-SY5Y cells. Exerts protective and trophic effects on neurons .
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2
2 Cited Publications
Cat. No.: HY-135190
CAS No.: 469-61-4
Purity:  ≥98.0%
Synonyms: α-cedrene
(-)-Cedrene (α-cedrene) is a major constituent that can be found in essential oils. (-)-Cedrene (α-cedrene) is a natural, orally active ligand of mouse olfactory receptor 23, which induces skeletal muscle hypertrophy in mice. (-)-Cedrene exhibits trypanocidal (Trypanosoma b. brucei) (IC50 = 4.07 μg/mL). (-)-Cedrene is antileukemic in vitro (IC50 = 22.2 μg/mL). (-)-Cedrene has antimicrobial activity against anaerobic bacteria and yeast. (-)-Cedrene exhibits anti-obesity activity .
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2
2 Cited Publications
Cat. No.: HY-Y0248A
CAS No.: 4602-84-0
Farnesol is a sesquiterpene alcohol that modulates cell-to-cell communication in Candida albicans, and has the activity in inhibiting bacteria.
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2
2 Cited Publications
Cat. No.: HY-N7015
CAS No.: 471-05-6
Zerumbone is an orally active natural cyclic sesquiterpene and can be isolated from Zingiber zerumbet. Zerumbone has anti-proliferative, anti-inflammation, anti-cancer, anti-bacterial and anti-mutagenic activity .
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2
2 Cited Publications
Cat. No.: HY-N6843
CAS No.: 34532-68-8
Arnicolide D is a sesquiterpene lactone that can be isolated from Centipeda minima. Arnicolide D is cytotoxic to tumor cells and can induce cell cycle arrest, apoptosis, and oncosis in tumor cells. Arnicolide D has anti-tumor activity .
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2
2 Cited Publications
Cat. No.: HY-114519
CAS No.: 10180-86-6
Purity:  99.55%
Helenalin acetate, a natural NF-κB inhibitor, is a potent C/EBPβ inhibitor. Helenalin acetate has anti-inflammatory and anticancer activities .
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2
2 Cited Publications
Cat. No.: HY-N0440
CAS No.: 6902-91-6
Germacrone is a sesquiterpene compound with multiple biological activities. Germacrone inhibits the H1N1 and H3N2 influenza A virus and the influenza B virus. Germacrone blocks the progressionof arthritis by regulating Th1/Th2 balance and inhibiting NF-κB signaling. Germacrone can arrest the cell cycle at G0/G1 and G2/M phases and induce apoptosis in breast cancer cells. Germacrone inhibits 5α-reductase and has anti-androgenic effect. Germacrone has neuroprotective functions and can be used for the study of traumatic brain injury (TBI). Germacrone also has antioxidant activity .
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1
1 Cited Publications
Cat. No.: HY-120838
CAS No.: 57710-57-3
Purity:  97.50%
Synonyms: Koningic acid
Target:  

Caspase

Research Areas:  

Infection Cancer

Heptelidic acid (Koningic acid) is a sesquiterpene antibiotic . Heptelidic acid inhibits Etoposide-induced apoptosis via downregulation of caspases . Koningic acid (KA) is a specific GAPDH inhibitor with an IC50of 90 μM .
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1
1 Cited Publications
Cat. No.: HY-108450
CAS No.: 6754-20-7
Purity:  98.74%
Synonyms: Poligodial; Tadeonal
Polygodial (Poligodial) is an antifungal potentiator . Polygodial is a sesquiterpene with anti-hyperalgesic properties .
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1
1 Cited Publications
Cat. No.: HY-N8619
CAS No.: 1367351-41-4
Minimolide F is a sesquiterpene lactone. Minimolide F has inhibitory activity against human nasopharyngeal cancer cells. Minimolide F can be used for the research of cancer .
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1
1 Cited Publications
Cat. No.: HY-136552
CAS No.: 495-61-4
Purity:  97.28%
β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an anti-cancer agent, can be used for the study of breast cancer .
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