β-Bisabolene
Based on 1 publication(s) in Google Scholar
β-Bisabolene is a sesquiterpene isolated from opoponax (Commiphora guidotti). β-Bisabolene, an anti-cancer agent, can be used for the study of breast cancer.
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- Purity: 95.08%
- CAS No.: 495-61-4
- 화학식: C15H24
- 분자량:204.35
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보관:
-20°C, sealed storage, away from moisture and light, under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) β-Bisabolene
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | EC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human A549 cells after 72 hrs by SRB assay
Cytotoxicity against human A549 cells after 72 hrs by SRB assay
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[PMID: 20073490] |
| KB | EC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human KB cells after 72 hrs by SRB assay
Cytotoxicity against human KB cells after 72 hrs by SRB assay
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[PMID: 20073490] |
| MCF7 | EC50 |
>20 μg/mL
Compound: 7
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Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay
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[PMID: 20073490] |
β-Bisabolene exhibits selective cytotoxic activity for mouse cells, it against normal Eph4, MG1361 and 4T1 cells with IC50 values of >200 µg/ml, 65.49 µg/ml, and 48.99 µg/ml, respectively. It against normal MCF-10A, MCF-7, MDA-MB-231, SKBR3 and BT474 cells with IC50 values of 114.3 µg/mL, 66.91 µg/mL, 98.39 µg/mL, 70.62 µg/mL and 74.3 µg/mL, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 495-61-4
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Appearance Liquid (Density: 0.8673 g/cm3)
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분자량 204.35
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화학식 C15H24
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Color Colorless to light yellow
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SMILES
C/C(C)=C\CCC([C@@H]1CC=C(C)CC1)=C
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Structure Classification
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Initial Source
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선적
Room temperature in continental US; may vary elsewhere.
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보관
-20°C, sealed storage, away from moisture and light, under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
Publications (1)
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Journal Impact Factor
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Most Recent
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Eur J Pharmacol
Study of the ameliorative effect of β-Bisabolene on ischemic stroke via COX-2 with the Keap1/Nrf2 and MAPK pathways. [Abstract]2025 Aug 15:1001:177773. PMID: 40441590
용액&용해도
DMSO : 100 mg/mL (489.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.23 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL. * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen)
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (270 KB)
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SDS (560 KB)
- English - EN (560 KB)
- Français - FR (560 KB)
- Deutsch - DE (560 KB)
- Norwegian - NO (560 KB)
- Español - ES (560 KB)
- Swedish - SV (560 KB)
- Italian - IT (560 KB)
- Korean - KR (560 KB)
- Portuguese - PT (560 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light, under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 4.8936 mL | 24.4678 mL | 48.9356 mL | 122.3391 mL |
| 5 mM | 0.9787 mL | 4.8936 mL | 9.7871 mL | 24.4678 mL | |
| 10 mM | 0.4894 mL | 2.4468 mL | 4.8936 mL | 12.2339 mL | |
| 15 mM | 0.3262 mL | 1.6312 mL | 3.2624 mL | 8.1559 mL | |
| 20 mM | 0.2447 mL | 1.2234 mL | 2.4468 mL | 6.1170 mL | |
| 25 mM | 0.1957 mL | 0.9787 mL | 1.9574 mL | 4.8936 mL | |
| 30 mM | 0.1631 mL | 0.8156 mL | 1.6312 mL | 4.0780 mL | |
| 40 mM | 0.1223 mL | 0.6117 mL | 1.2234 mL | 3.0585 mL | |
| 50 mM | 0.0979 mL | 0.4894 mL | 0.9787 mL | 2.4468 mL | |
| 60 mM | 0.0816 mL | 0.4078 mL | 0.8156 mL | 2.0390 mL | |
| 80 mM | 0.0612 mL | 0.3058 mL | 0.6117 mL | 1.5292 mL | |
| 100 mM | 0.0489 mL | 0.2447 mL | 0.4894 mL | 1.2234 mL |
β-Bisabolene Related Classifications
HY-136552 Related Classifications
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