3 Results for "

Stephania species

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Stephania species" in MCE Product Catalog:

5
Crebanine
Crebanine
0 Images
5 Cited Publications
Cat. No.: HY-N2255
CAS No.: 25127-29-1
Category:  

Cardiovascular Disease Alkaloids Stephania venosa Other Alkaloids Plants Disease Research Fields Inflammation/Immunology Menispermaceae

Target:  

Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial

Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC50 of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na + current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease .
loading...
    loading...
View All Sizes
Homostephanoline
Homostephanoline
0 Images
Cat. No.: HY-N18876
CAS No.: 2689-15-8
Category:  

Alkaloids Aporphine Alkaloids Plants Menispermaceae Stephania japonica (Thunb.) Miers

Target:  

Drug Derivative

Homostephanoline is a corydane-type alkaloid that can be isolated from species of the Stephania subgenus .
loading...
    loading...
View All Sizes
(+)-Laudanidine
(+)-Laudanidine
0 Images
Cat. No.: HY-W701798
CAS No.: 3122-95-0
Synonyms: (S)-Tritopin; D-Laudanine
Category:  

Alkaloids Cuscuta reflexa Roxb. Plants Isoquinoline Alkaloids Convolvulaceae Cuscuta chinensis Lam.

Target:  

Drug Derivative

(+)-Laudanidine ((S)-Tritopin) is a benzyltetrahydroisoquinoline alkaloid found in Stephania species .
loading...
    loading...
View All Sizes
Assay Types