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Stephania species

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Reactive Oxygen Species (ROS) (1) Akt (1) Apoptosis (1) Bacterial (1) Drug Derivative (2) ERK (1) Interleukin Related (1) nAChR (1) NF-κB (1) NO Synthase (1) p38 MAPK (1) TNF Receptor (1)
By Research Areas:	Cancer (1)

Inhibitors & Agonists

Targets Recommended: Reactive Oxygen Species (ROS)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

Crebanine 4 Publications Verification	Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial	Cancer
Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC₅₀ of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na ⁺ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease .

Homostephanoline	Drug Derivative	Others
Homostephanoline is a corydane-type alkaloid that can be isolated from species of the Stephania subgenus .

(+)-Laudanidine (S)-Tritopin; D-Laudanine	Drug Derivative	Others
(+)-Laudanidine ((S)-Tritopin) is a benzyltetrahydroisoquinoline alkaloid found in Stephania species .

Crebanine 4 Publications Verification	Cardiovascular Disease Structural Classification Alkaloids Stephania venosa Classification of Application Fields Other Alkaloids Plants Menispermaceae Inflammation/Immunology Disease Research Fields	Akt Apoptosis NF-κB Reactive Oxygen Species (ROS) p38 MAPK ERK Interleukin Related TNF Receptor NO Synthase nAChR Bacterial
Crebanine is an isoquinoline-like alkaloid that can be derived from Stephania. Crebanine is an antagonist of the α7-nAChR with an IC₅₀ of 19.1 μM. Crebanine suppresses the proliferation, migration, and invasion of cancer cells, triggers reactive oxygen species (ROS) burst, and promotes apoptosis. Crebanine inhibits the AKT/FoxO3a, NF-κB and MAPK signaling pathways. Crebanine attenuates NOX2 hyperactivation, exhibits antioxidant properties by reducing reactive oxygen species and peroxidation in microglia cells. Crebanine inhibits voltage-dependent Na ⁺ current in guinea-pig ventricular myocytes. Crebanine has high inhibitory activity against gram-positive animal pathogenic bacteria. Crebanine ameliorates ischemia-reperfusion brain damage in middle cerebral artery occlusion and reperfusion (MCAO/R) rats. Crebanine significantly improves Scopolamine (HY-N0296)-induced cognitive deficits in ICR mice. Crebanine can be used for the study of hepatocellular carcinoma (HCC), cerebral ischemia and Alzheimer's disease .

Homostephanoline	Structural Classification Alkaloids Aporphine Alkaloids Plants Menispermaceae Stephania japonica (Thunb.) Miers Source Classification	Drug Derivative
Homostephanoline is a corydane-type alkaloid that can be isolated from species of the Stephania subgenus .

(+)-Laudanidine (S)-Tritopin; D-Laudanine	Structural Classification Alkaloids Cuscuta reflexa Roxb. Plants Isoquinoline Alkaloids Convolvulaceae Cuscuta chinensis Lam. Source Classification	Drug Derivative
(+)-Laudanidine ((S)-Tritopin) is a benzyltetrahydroisoquinoline alkaloid found in Stephania species .

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