Search Result

Results for "

Sulfonamides

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acetolactate Synthase (ALS) (1) Akt (3) Aminoacyl-tRNA Synthetase (1) Angiotensin Receptor (1) Antibiotic (101) Apoptosis (9) Autophagy (6) Bacterial (119) Biochemical Assay Reagents (8) Bombesin Receptor (1) Carbonic Anhydrase (17) Caspase (3) CD1 (1) CDK (1) Ceramidase (1) Cholinesterase (ChE) (1) COX (4) Cuproptosis (1) CXCR (2) Cytochrome P450 (4) Dengue Virus (1) Dihydrofolate reductase (DHFR) (2) DNA-PK (3) DNA/RNA Synthesis (2) Drug Derivative (5) Drug Intermediate (7) Drug Metabolite (4) EGFR (1) Endogenous Metabolite (7) Endothelin Receptor (3) Environmental Pollutants (8) Ferroptosis (1) Flavivirus (1) Fluorescent Dye (3) Fungal (11) HBV (1) HCV (1) Herbicide (1) HIV (3) HSP (1) ICMT (1) IFNAR (1) Insulin Receptor (2) Integrin (2) Interleukin Related (1) Isotope-Labeled Compounds (43) Ligands for Target Protein for PROTAC (1) LIM Kinase (LIMK) (1) MDM-2/p53 (3) Melanocortin Receptor (1) MetAP (1) Microtubule/Tubulin (4) Mitochondrial Metabolism (1) MMP (1) Molecular Glues (5) mTOR (2) Necroptosis (3) Neuropeptide Y Receptor (2) NF-κB (1) NKCC (4) Nucleoside Antimetabolite/Analog (1) Orexin Receptor (OX Receptor) (2) PANK (1) Parasite (26) PARP (3) PDK-1 (1) Phosphodiesterase (PDE) (1) Potassium Channel (2) Proton Pump (1) Raf (1) Reactive Oxygen Species (ROS) (7) Reference Standards (44) ROR (1) Sodium Channel (8) Tau Protein (1) Topoisomerase (2) Trk Receptor (1) Wnt (1) γ-secretase (3)
By Research Areas:	Cancer (46) Cardiovascular Disease (9) Endocrinology (8) Infection (132) Inflammation/Immunology (29) Metabolic Disease (16) Neurological Disease (22)
Click Chemistry:	Labeling and Fluorescence Imaging (1) Alkynes (1)

247

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Isotope-Labeled Compounds

Click Chemistry

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1218

Sulfaphenazole 10+ Cited Publications	Cytochrome P450 Antibiotic Bacterial Necroptosis Apoptosis	Infection Cardiovascular Disease
Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion .

HY-14571

E7820 5 Publications Verification ER68203-00	Molecular Glues Integrin	Infection Metabolic Disease Cancer
E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 ^DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC₅₀ of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) .

HY-107321

Azosemide 3 Publications Verification	NKCC	Metabolic Disease
Azosemide, a sulfonamide loop diuretic, is a potent NKCC1 inhibitor with IC₅₀s of 0.246 μM and 0.197 μM for hNKCC1A and NKCC1B, respectively .

HY-B0507

Sulfathiazole 5 Publications Verification	Environmental Pollutants Antibiotic Bacterial	Endocrinology Cancer
Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish .

HY-B0273

Sulfadiazine 5+ Cited Publications	Bacterial Parasite Antibiotic	Infection
Sulfadiazine is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research .

HY-B0322S

Sulfamethoxazole-d4 1 Publications Verification Ro 4-2130-d₄	Isotope-Labeled Compounds Antibiotic Bacterial	Infection
Sulfamethoxazole-d₄ (Ro 4-2130-d₄) is a deuterium labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .

HY-B1267

Sulfaguanidine 2 Publications Verification	Bacterial Antibiotic	Infection
Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery .

HY-B0512

Sulfamerazine 4 Publications Verification RP2632	Bacterial Antibiotic	Infection
Sulfamerazine (RP-2632) is a sulfonamide antibacterial.

HY-B0337

Sulfadimethoxine 3 Publications Verification Sulphadimethoxine	Bacterial Antibiotic	Infection
Sulfadimethoxine (Sulphadimethoxine) is a sulfonamide antibiotic used to treat many infections .

HY-B0273A

Sulfadiazine sodium 5+ Cited Publications	Bacterial Parasite Antibiotic	Infection
Sulfadiazine sodium is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research .

HY-B0946

Sulfamonomethoxine 1 Publications Verification	Antibiotic Bacterial	Infection
Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .

HY-139081

GDC-0310	Sodium Channel	Neurological Disease
GDC-0310 is a selective acyl-sulfonamide Na_v1.7 inhibitor, with an IC₅₀ of 0.6 nM for hNa_v1.7 .

HY-B1781

Sulfachloropyridazine 2 Publications Verification Sulfachlorpyridazine	Bacterial Antibiotic	Infection
Sulfachloropyridazine is a broad spectrum sulfonamide that can be used against both gram-positive and gram-negative aerobic bacteria as well as Chlamydia. Sulfachloropyridazine is also considered as a common pollutant in surface and groundwater. Sulfachloropyridazine via electro-Fenton is a model for sulfonamide antibiotics that are widespread in waters .

HY-B1784

Sulfisomidin Sulfaisodimidine	Bacterial Antibiotic	Infection
Sulfisomidin (Sulfaisodimidine) is an orally active short-acting sulfonamide antibacterial. Sulfisomidin can be used for the research of lower urinary tract infections .

HY-B1386

Halazone	Environmental Pollutants Bacterial Sodium Channel Carbonic Anhydrase	Infection
Halazone is an atypical antimicrobial sulfonamide derivative and a carbonic anhydrase II inhibitor with a K_d value of 1.45 μM. Halazone protects sodium channels from inactivation. Halazone is widely used for disinfection of drinking water .

HY-W033049

DABCO-Bis(sulfur dioxide) DABSO	Biochemical Assay Reagents	Others
DABCO-Bis(sulfur dioxide) (DABSO) is a source of sulfur dioxide in organic synthesis and can be used in the preparation of sulfonamides and sulfonamides .

HY-106662

Chloroquinoxaline sulfonamide Chloroquinoxaline; NSC-339004	Molecular Glues Topoisomerase Parasite	Infection Cancer
Chloroquinoxaline sulfonamide (Chloroquinoxaline), a structural analogue of sulfaquinoxaline, is a topoisomerase II alpha/beta poison. Chloroquinoxaline sulfonamide is used to control coccidiosis in poultry, rabbit, sheep, and cattle . Antitumor activity .

HY-120553

B-355252 1 Publications Verification	Apoptosis	Neurological Disease
B355252, a phenoxy thiophene sulfonamide small molecule, is a potent NGF receptor agonist. B355252 potentiates NGF-induced neurite outgrowth. B355252 protects ischemic neurons from neuronal loss by attenuating DNA damage, reducing ROS production and the LDH level, and preventing neuronal apoptosis. B355252 has anti-apoptotic effects in glutamate-induced excitotoxicity, as well as in a murine hippocampal cell line (HT22) model of Parkinson disease (PD) .

HY-108425B

(Rac)-AMG8379 (Rac)-AMG8380	Sodium Channel	Neurological Disease
(Rac)-AMG8379 ((Rac)-AMG8380) is a racemate of AMG8379. AMG8379 is a potent, orally active and selective sulfonamide antagonist of NaV1.7, with IC₅₀s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively .

HY-B0322S1

Sulfamethoxazole-13C6 Ro 4-2130-¹³C₆	Isotope-Labeled Compounds Antibiotic Bacterial	Infection
Sulfamethoxazole- ¹³C₆ (Ro 4-2130- ¹³C₆) is a ¹³C labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .

HY-B0576

Sulfacetamide sodium 3 Publications Verification Sulphacetamide sodium	Antibiotic Bacterial Fungal	Infection Inflammation/Immunology
Sulfacetamide (Sulphacetamide) sodium is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide sodium has antifungal and antibacterial activities .

HY-B1236

Sulfacarbamide 2 Publications Verification Sulfanilylurea; Urosulfan	Bacterial	Infection Metabolic Disease
Sulfacarbamide (Sulfanilylurea, Urosulfan) is an orally active class of sulfonamides with an antimicrobial activity. Sulfacarbamide can be used for the study of diabetes .

HY-U00131

Sulfabrom N 3517; Sulfabromomethazine	Bacterial	Infection
Sulfabrom (N 3517; Sulfabromomethazine) is a long-acting Sulfonamide that is used for the treatment of coccidiosis and various bacterial infections in the poultry, swine and cattle.

HY-B0273S

Sulfadiazine-d4	Bacterial	Infection
Sulfadiazine-d₄ is a deuterium labeled Sulfadiazine. Sulfadiazine is a sulfonamide antibiotic used for the treatment of toxoplasmosis .

HY-16472

Sulfacytine	Antibiotic Bacterial	Infection
Sulfacytine is a short-acting sulfonamide antibiotic. Sulfacytine is active against bacteria and is an effective agent for the research of acute uncomplicated urinary tract infections .

HY-W587780

Sulfamethoxazole-NO SMX-NO	Biochemical Assay Reagents	Inflammation/Immunology
Sulfamethoxazole-NO (SMX-NO) is the major immunogen in sulfonamide allergy, producing modest ascorbic acid depletion and hemoglobin adduct formation. Sulfamethoxazole-NO haptens tissue proteins and is immunogenic in rodents .

HY-69077

5-Bromo-1H-pyrazolo[3,4-b]pyridine	Drug Intermediate	Infection
5-Bromo-1H-pyrazolo[3,4-b]pyridine is a drug intermediate that can be used for the synthesis of sulfonamide derivatives.

HY-108425

AMG8379	Sodium Channel	Neurological Disease
AMG8379 is a potent, orally active and selective sulfonamide antagonist of the voltage-gated sodium channel NaV1.7, with IC₅₀s of 8.5 and 18.6 nM for hNaV1.7 and mNaV1.7, respectively. AMG8379 potently and reversibly blocks endogenous Tetrodotoxin (TTX)-sensitive sodium channels in dorsal root ganglia (DRG) neurons with an IC₅₀ of 3.1 nM .

HY-W587805

Perfluorohexane sulfonamide FHxSA	Carbonic Anhydrase	Others
Perfluorohexane sulfonamide (FHxSA) is the inhibitor for carbonic anhydrase, that inhibits bovine CA and human CA II with IC₅₀ of 0.122 and 1.38 μM. Perfluorohexane sulfonamide is a delayed-action insecticide, that can be used to control red fire ants (Solenopsis invicta). Perfluorohexane sulfonamide could be a environmental pollutant .

HY-W041324

Glimepiride sulfonamide	Drug Intermediate	Infection
Glimepiride sulfonamide is a intermediate, and can be used to synthesize Glimepiride (HY-B0104) (antidiabetic agent) .

HY-B0888

Sulfacetamide sodium monohydrate 3 Publications Verification Sulphacetamide sodium monohydrate	Antibiotic Bacterial Fungal	Infection Inflammation/Immunology
Sulfacetamide (Sulphacetamide) sodium monohydrate is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide sodium monohydrate has antifungal and antibacterial activities .

HY-B0212S

Sulfapyridine-d4	Isotope-Labeled Compounds Bacterial	Infection
Sulfapyridine-d₄ a deuterium labeled Sulfapyridine. Sulfapyridine is a sulfonamide antibacterial .

HY-B0273R

Sulfadiazine (Standard)	Reference Standards Bacterial Parasite Antibiotic	Infection
Sulfadiazine (Standard) is the analytical standard of Sulfadiazine. This product is intended for research and analytical applications. Sulfadiazine is a sulfonamide antibiotic with antimalarial activity. Sulfadiazine can be used for toxoplasmosis research .

HY-177331

BTT-3034	Integrin	Cardiovascular Disease
BTT-3034, a sulfonamide derivative, is an α2β1 integrin inhibitor. BTT-3034 inhibits cell adhesion to rat tail collagen I with an EC₅₀ of 160 nM and a corresponding E_maxof 86%. BTT-3034 inhibits collagen binding by an α2 variant carrying the conformationally activating E318W mutation .

HY-B1267R

Sulfaguanidine (Standard)	Reference Standards Bacterial Antibiotic	Infection
Sulfaguanidine (Standard) is the analytical standard of Sulfaguanidine. This product is intended for research and analytical applications. Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery .

HY-148431

Antimicrobial agent-14	Bacterial	Infection
Antimicrobial agent-14, a benzyl thiophene sulfonamide derivative is an antimicrobial agent, with a MIC of 200 μM against Campylobacter coli ATCC33559. Antimicrobial agent-14 can be used for the research of bacterial foodborne gastroenteritis .

HY-B0946S

Sulfamonomethoxine-d4	Isotope-Labeled Compounds Antibiotic Bacterial	Infection
Sulfamonomethoxine-d₄ is a deuterium labeled Sulfamonomethoxine (HY-B0946). Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .

HY-B0512A

Sulfamerazine sodium salt Soluble sulfamerazine	Bacterial Antibiotic	Infection
Sulfamerazine Sodium is a sulfonamide antibacterial.

HY-106570

Tripamide	Potassium Channel	Metabolic Disease
Tripamide is an orally active sulfonamide-derived diuretic antihypertensive agent .

HY-B0323C

Sulfisoxazole 100 µg/mL in methanol Sulfafurazole 100 µg/mL in methanol	Bacterial Biochemical Assay Reagents	Infection
Sulfisoxazole 100 μg/mL in methanol (Sulfafurazole 100 μg/mL in methanol) is a sulfonamide antimicrobial compound.

HY-B1781R

Sulfachloropyridazine (Standard) Sulfachlorpyridazine (Standard)	Reference Standards Bacterial Antibiotic	Infection
Sulfachloropyridazine (Standard) is the analytical standard of Sulfachloropyridazine. This product is intended for research and analytical applications. Sulfachloropyridazine is a broad spectrum sulfonamide that can be used against both gram-positive and gram-negative aerobic bacteria as well as Chlamydia. Sulfachloropyridazine is also considered as a common pollutant in surface and groundwater. Sulfachloropyridazine via electro-Fenton is a model for sulfonamide antibiotics that are widespread in waters .

HY-Y0544S

*N-Methyl-N-nitrosotoluene-4-sulfonamide-d3*	Isotope-Labeled Compounds	Others
N-Methyl-N-nitrosotoluene-4-sulfonamide-d₃ is the deuterium labeled N-Methyl-N-nitrosotoluene-4-sulfonamide .

HY-112586

Sulfaethoxypyridazine	Bacterial Antibiotic	Infection
Sulfaethoxypyridazine is a sulfonamide antibacterial agent. Sulfaethoxypyridazine is a sulfonamide that is used in veterinary medicine as feedstuffs .

HY-101829

Sulfaproxiline Sulfaproxylin; Sulfaproxyline	Antibiotic Bacterial	Infection
Sulfaproxyline (Sulfaproxylin; Sulfaproxyline) is a sulfonamide antibiotic that inhibits bacterial dihydropteroate synthase, thereby blocking folate biosynthesis required for nucleic acid production. Sulfaproxyline shows antimicrobial activity primarily against Staphylococcus species and common uropathogens. Sulfaproxyline reduces bacterial growth by impairing DNA and protein synthesis. Sulfaproxyline can be used for research of staphylococcal and urinary tract infections .

HY-B1218R

Sulfaphenazole (Standard)	Reference Standards Cytochrome P450 Antibiotic Bacterial Necroptosis Apoptosis	Infection Cardiovascular Disease
Sulfaphenazole (Standard) is the analytical standard of Sulfaphenazole. This product is intended for research and analytical applications. Sulfaphenazole is a selective inhibitor of human cytochrome P450 (CYP) 2C9 enzyme. Sulfaphenazole is a cytoprotective agent against light-induced death of photoreceptors. Sulfaphenazole inhibits light-induced necrosis and mitochondrial stress-initiated apoptosis. Sulfaphenazole is an off patent sulfonamide antibiotic and demonstrates bactericidal activity through enhanced M1 macrophage activity. Sulfaphenazole can significantly reduce infarct size and restore post-ischemic coronary flow following ischemia and reperfusion .

HY-204927A

*1-Methyl-N-(4-(piperidin-1-yl)phenyl)-1H-imidazole-4-sulfonamide* TFA**	Drug Intermediate	Others
1-Methyl-N-(4-(piperidin-1-yl)phenyl)-1H-imidazole-4-sulfonamide TFA is a pharmaceutical synthesis intermediate.

HY-B1781A

Sulfachloropyridazine sodium Sulfachlorpyridazine sodium	Bacterial Antibiotic	Infection
Sulfachloropyridazine (sodium) is a sulfonamide antibiotic that inhibits bacterial growth .

HY-B0337S2

Sulfadimethoxine-13C6 Sulphadimethoxine-¹³C₆	Isotope-Labeled Compounds Bacterial Antibiotic	Infection
Sulfadimethoxine- ¹³C₆ is the ¹³C-labeled Sulfadimethoxine. Sulfadimethoxine (Sulphadimethoxine) is a sulfonamide antibiotic used to treat many infections .

HY-133933

Maleylsulfathiazole	Drug Derivative	Others
Maleylsulfathiazole is an N ⁴-dibasic acid-substituted sulfonamides .

HY-B0273S1

Sulfadiazine-13C6	Isotope-Labeled Compounds Bacterial Parasite Antibiotic	Infection
Sulfadiazine- ¹³C₆ is a labeled Sulfadiazine (HY-B0273). Sulfadiazine is a sulfonamide?antibiotic with antimalarial activity[1].

Cat. No.	Product Name	Type

HY-D0017

Dansyl chloride DNSCl	Fluorescent Dye
Dansyl chloride is a reagent that produces stable blue or blue-green fluorescent sulfonamide adducts in the reaction of aliphatic and aromatic amines with primary amino groups, and is widely used for modified amino acids, protein sequencing and amino acid analysis .

HY-D3200

Dns–LLC

Fluorescent Dye

Dns-LLC is a cell-permeable Cu ⁺-selective fluorescent probe that forms a 1:1 complex with Cu ⁺. The thiol group of Dns-LLC plays a key binding role, while the sulfonamide and amide groups jointly contribute to the stabilization of the complex. Upon binding to Cu ⁺ in aqueous buffer solutions, Dns-LLC generates a turn-on fluorescence response, which can be used for the detection of Cu ⁺ in the Golgi apparatus .

Cat. No.	Product Name	Type

HY-W033049

DABCO-Bis(sulfur dioxide) DABSO	Biochemical Assay Reagents
DABCO-Bis(sulfur dioxide) (DABSO) is a source of sulfur dioxide in organic synthesis and can be used in the preparation of sulfonamides and sulfonamides .

HY-69077

5-Bromo-1H-pyrazolo[3,4-b]pyridine	Biochemical Assay Reagents
5-Bromo-1H-pyrazolo[3,4-b]pyridine is a drug intermediate that can be used for the synthesis of sulfonamide derivatives.

HY-W004121

4-Biphenylsulfonyl chloride

Biochemical Assay Reagents

4-Biphenylsulfonyl chloride is a synthetic intermediate that participates in the sulfonamide formation reaction to synthesize antiproliferative compounds. The derivatives of 4-Biphenylsulfonyl chloride inhibit human head and neck squamous cell carcinoma (HNSCC) cells by increasing PTEN expression and inhibiting the PI3K/Akt/mTOR pathway. 4-Biphenylsulfonyl chloride can be used in the development of anticancer drugs for HNSCC .

HY-W008497

2-Chloro-5-nitrobenzene sulfonamide	Biochemical Assay Reagents
2-Chloro-5-nitrobenzene sulfonamide is a biochemical reagent.

Cat. No.	Product Name	Target	Research Area

HY-P4070

Insulin icodec	Insulin Receptor	Metabolic Disease
Insulin icodec is an Insulin (HY-P0035) analog that strongly but reversibly binds to albumin. Insulin icodec has long plasma half-life. Insulin icodec modulates insulin receptor activity, controls blood glucose levels, reduces HbA_1c levels, and binds reversibly to human serum albumin. Insulin icodec can be used for the research of type 2 diabetes mellitus .

HY-P1103

CTCE-9908 1 Publications Verification	CXCR	Cancer
CTCE-9908 is a potent and selective CXCR4 antagonist. CTCE-9908 induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .

HY-P1103A

CTCE-9908 TFA	CXCR	Cancer
CTCE-9908 TFA is a potent and selective CXCR4 antagonist. CTCE-9908 TFA induces mitotic catastrophe, cytotoxicity and inhibits migration in CXCR4-expressing ovarian cancer cells .

HY-P4757

N1-Glutathionyl-spermidine disulfide	Parasite	Others
N1-Glutathionyl-spermidine disulfide is a substrate of trypanothione reductase .

HY-P11293

DOTA-GGNle-CycMSHhex	Melanocortin Receptor	Cancer
DOTA-GGNle-CycMSHhex is a melanocortin-1 receptor (MC1R)-targeting peptide that can be radionuclide-labeled for melanoma imaging .

HY-P1321

GR231118 1229U91; GW1229	Neuropeptide Y Receptor	Neurological Disease
GR231118, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide Y Y receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide Y Y4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide YY2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide Y Y6 receptor (pK_i= 8.8) .

HY-P1321A

GR231118 TFA 1229U91 TFA; GW1229 TFA	Neuropeptide Y Receptor	Neurological Disease
GR231118 TFA, an analogue of the C-terminus of neuropeptide Y, is a potent , competitive and relative seletive antagonist at human neuropeptide YY receptor with a pK_i of 10.4. GR231118 a potent agonist at the human neuropeptide YY4 receptor (pEC₅₀=8.6; pK_i=9.6) and a weak agonist at the human and rat neuropeptide Y Y2 and Y5 receptors. GR231118 also has high affinity for the mouse neuropeptide YY6 receptor (pK_i= 8.8) .

HY-P11480

TrkA/NGF-IN-1	Trk Receptor	Neurological Disease
TrkA/NGF-IN-1 (Peptide 19) is an inhibitor of protein-protein interactions between TrkA and NGF (IC₅₀: 21 nM for human TrkA in PathHunter assay). TrkA/NGF-IN-1 shows an analgesic effect in a rat incisional pain model .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-B0439

Sulfadoxine Sulphadoxine	Infection Natural Products Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification	Parasite HIV Antibiotic Endogenous Metabolite
Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-N7123

Sulfacetamide 3 Publications Verification Sulphacetamide	Infection Classification of Application Fields Disease Research Fields	Environmental Pollutants Antibiotic Bacterial Fungal
Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic. Sulfacetamide has antifungal and antibacterial activities. Sulfacetamide is employed as a topical formulation in various ophthalmic, dermatological, and hair solutions against bacterial infections, acne and scalp conditions. Sulfacetamide targets bacterial folic acid synthesis and is effective against various gram-positive and gram-negative bacteria. Sulfacetamide inhibits the synthesis of both dihydro-folic acid and para-aminobenzoic acid. Sulfacetamide can be used for the study of ocular infections .

HY-121071

Ascamycin	Infection Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Other Antibiotics Source Classification	Bacterial Nucleoside Antimetabolite/Analog Antibiotic
Ascamycin is a 5'-O-sulfonamide ribonucleoside antibiotic produced by Streptomyces sp. JCM9888. Ascamycin has a selective antibacterial activity against *Xanthomonas* species with MIC values of 0.4 μg/mL, 12.5 μg/mL and 12.5 μg/mL for *Xanthomonas citri, Xanthomonas oryzae* and *Mycobacterium phlei*, respectively .

HY-B0439R

Sulfadoxine (Standard) Sulphadoxine (Standard)	Structural Classification Natural Products Endogenous metabolite Source Classification	Reference Standards Parasite HIV Antibiotic Endogenous Metabolite
Sulfadoxine (Standard) is the analytical standard of Sulfadoxine. This product is intended for research and analytical applications. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-133668R

Monoethyl phthalate (Standard)	Other disease Disease markers Endogenous metabolite	Drug Metabolite Reference Standards
Sulfamonomethoxine (sodium) (Standard) is the analytical standard of Sulfamonomethoxine (sodium). This product is intended for research and analytical applications. Sulfamonomethoxine sodium is a long acting sulfonamide antibacterial agent, used in blood kinetic studies,and blocks the synthesis of folic acid by inhibiting synthetase of dihydropteroate .

Cat. No.	Product Name	Chemical Structure

HY-B0322S

Sulfamethoxazole-d4

1 Publications Verification

Sulfamethoxazole-d₄ (Ro 4-2130-d₄) is a deuterium labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .

HY-D0017S

Dansyl chloride-d6
Dansyl chloride-d₆ is the deuterium labeled Dansyl chloride (HY-D0017). Dansyl chloride is a reagent that produces stable blue or blue-green fluorescent sulfonamide adducts in the reaction of aliphatic and aromatic amines with primary amino groups, and is widely used for modified amino acids, protein sequencing and amino acid analysis .

HY-B0322S1

Sulfamethoxazole-13C6

Sulfamethoxazole- ¹³C₆ (Ro 4-2130- ¹³C₆) is a ¹³C labeled Sulfamethoxazole (HY-B0322). Sulfamethoxazole (Ro 4-2130) is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis .

HY-B0035S

Sulfamethazine-d4
Sulfamethazine-d₄ (Sulfadimidine-d₄) is a deuterium labeled Sulfamethazine (Sulfadimidine). Sulfamethazine is an antimicrobial that is widely used to treat and prevent various animal diseases (such as gastrointestinal and respiratory tract infections) .

HY-B0273S

Sulfadiazine-d4
Sulfadiazine-d₄ is a deuterium labeled Sulfadiazine. Sulfadiazine is a sulfonamide antibiotic used for the treatment of toxoplasmosis .

HY-B0507S

Sulfathiazole-d4

Sulfathiazole-d₄ is a deuterium labeled Sulfathiazole. Sulfathiazole is an orally active, endocrine disruptor targeting the steroidogenic pathway, specifically enhancing the activity of CYP19 in human adrenal cancer cells (H295R) and upregulating the mRN expression of CYP17, CYP19, and 3β-HSD. Sulfathiazole increases the production of 17-estradiol (E2) and has endocrine disrupting effects on aquatic organisms such as the Japanese medaka fish .

HY-B0688S2

Dapsone-13C12

Dapsone- ¹³C₁₂ is the ¹³C₁₂ labeled Dapsone (HY-B0688). Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities. Dapsone exerts effective antileprosy activity and inhibits folate synthesis in cell extracts of M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-B0212S

Sulfapyridine-d4
Sulfapyridine-d₄ a deuterium labeled Sulfapyridine. Sulfapyridine is a sulfonamide antibacterial .

HY-B0946S

Sulfamonomethoxine-d4
Sulfamonomethoxine-d₄ is a deuterium labeled Sulfamonomethoxine (HY-B0946). Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .

HY-136382S

Sulfachloropyridazine-d4
Sulfachloropyridazine-d₄ is the deuterium labeled Sulfachloropyridazine. Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria .

HY-B1267S1

Sulfaguanidine-13C6
Sulfaguanidine- ¹³C₆ is the ¹³C₆ labeled Sulfaguanidine. Sulfaguanidine is an orally active antimicrobial agent/antibiotic of sulfonamide class. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery.

HY-N7123S

Sulfacetamide-d4
Sulfacetamide-d₄ (Sulphacetamide-d₄) is the deuterium labeled Sulfacetamide (HY-N7123). Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities .

HY-B0688S

Dapsone-d8
Dapsone-d₈ is a deuterium labeled Dapsone. Dapsone is an orally active and blood-brain penetrant sulfonamide antibiotic with antibacterial, antigenic and anti-inflammatory activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone can be used as an anticonvulsant and also in the research of skin and glioblastoma diseases .

HY-B0439S1

Sulfadoxine D3

Sulfadoxine-d₃ is a deuterium labeled Sulfadoxine (HY-B0439). Sulfadoxine is a sulfonamide that is used, usually in combination with Pyrimethamine(HY-18062), for multidrug-resistant Plasmodium falciparum and P. vivax inhibition. Unlike PYR, Sulfadoxine has no impact on HIV replication or MT-2 cell cycle progression. But also Sulfadoxine exhibits suppression on respiratory, and urinary tract infections .

HY-B0960S

Sulfabenzamide-d4

Sulfabenzamide (N-Sulfanilylbenzamide)-d₄ is the deuterium labeled Sulfabenzamide (HY-B0960). Sulfabenzamide is a sulfonamide antibacterial agent. Sulfabenzamide exhibit antibacterial activity against Staphylococcus aureus (ATCC 25923) and Escherichia coli (ATCC 8739). Sulfabenzamide can promote autophagic cell autophagy in breast cancer cells through p53/ DRAM pathway. Sulfabenzamide increases caspase-3 activity, deactivates PARP1 and DNA-PK, downregulates AKT1 and AKT2. Sulfabenzamide can be used for the researches of breast cancer and bacterial infections .

HY-Y0544S

*N-Methyl-N-nitrosotoluene-4-sulfonamide-d3*
N-Methyl-N-nitrosotoluene-4-sulfonamide-d₃ is the deuterium labeled N-Methyl-N-nitrosotoluene-4-sulfonamide .

HY-B0337S2

Sulfadimethoxine-13C6
Sulfadimethoxine- ¹³C₆ is the ¹³C-labeled Sulfadimethoxine. Sulfadimethoxine (Sulphadimethoxine) is a sulfonamide antibiotic used to treat many infections .

HY-B0553S

Methazolamide-d6
Methazolamide-d₆ is the deuterium labeled Methazolamide. Methazolamide (L584601) is a sulfonamide derivative used as a carbonic anhydrase inhibitor with a K_i of 14 nM for human carbonic anhydrase II. Methazolamide, an intraocular pressure-lowering agent, reduces intraocular pressure elevations associated with glaucoma and other ocular disorders .

HY-B0688S1

Dapsone-d4

Dapsone-d₄ is the deuterium labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-B0273S1

Sulfadiazine-13C6
Sulfadiazine- ¹³C₆ is a labeled Sulfadiazine (HY-B0273). Sulfadiazine is a sulfonamide?antibiotic with antimalarial activity[1].

HY-135393S

Sulfadimethoxypyrimidine-d4
Sulfadimethoxypyrimidine-d₄ is a deuterium labeled Sulfadimethoxypyrimidine. Sulfadimethoxypyrimidine is a sulfonamide antibiotic with a broad-spectrum antibacterial effect .

HY-B0337S

Sulfadimethoxine-d4
Sulfadimethoxine-d₄ is a deuterium labeled Sulfadimethoxine (Sulphadimethoxine). Sulfadimethoxine is a sulfonamide antibiotic used to treat many infections including treatment of respiratory, urinary tract, enteric, and soft tissue infections .

HY-B1267S

Sulfaguanidine-d4
Sulfaguanidine-d₄ is the deuterium labeled Sulfaguanidine. Sulfaguanidine, belongs to the class of sulfonamide agent, is an orally active antibiotic. Sulfaguanidine can be used for the research of enteric infections such as bacillary dysentery .

HY-B0512S

Sulfamerazine-d4
Sulfamerazine-d₄ is a deuterium labeled Sulfamerazine. Sulfamerazine, a sulfonamide antibacterial, inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes .

HY-W726534

5-Methyl-1-(methyl-d3)-1H-pyrazole-4-sulfonamide
5-Methyl-1-(methyl-d₃)-1H-pyrazole-4-sulfonamide is the deuterium labeled 5-Methyl-1-(methyl)-1H-pyrazole-4-sulfonamide.

HY-W724450

3-Methyl-1-(methyl-d3)-1H-pyrazole-4-sulfonamide
3-Methyl-1-(methyl-d₃)-1H-pyrazole-4-sulfonamide is the deuterium labeled 1,3-Dimethyl-1H-pyrazole-4-sulfonamide (HY-W060881).

HY-79602S

4-Tolyl-d4-sulfonamide
4-Tolyl-sulfonamide-d₄ is the deuterium labeled 4-Tolyl-sulfonamide .

HY-112586S1

Sulfaethoxypyridazine-13C6
Sulfaethoxypyridazine- ¹³C₆ is the ¹³C₆ labeled Sulfaethoxypyridazine. Sulfaethoxypyridazine is a sulfonamide antibacterial agent. Sulfaethoxypyridazine is a sulfonamide that is used in veterinary medicine as feedstuffs.

HY-W662572S

Pyroxsulam-d6
Pyroxsulam-d₆ (N-(5,7-Dimethoxy-d₆[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide) is deuterium labeled N-(5,7-Dimethoxy-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-2-methoxy-4-(trifluoromethyl)pyridine-3-sulfonamide .

HY-W027544S1

Dansyl propargylamine-d6
Dansyl propargylamine-d₆ (5-(Dimethylamino)-N-(prop-2-yn-1-yl)naphthalene-1-sulfonamide-d₆) is the deuterium labeled Dansyl propargylamine .

HY-B0337S1

Sulfadimethoxine-d6
Sulfadimethoxine-d₆ is the deuterium labeled Sulfadimethoxine. Sulfadimethoxine is a sulfonamide antibiotic used to treat many infections .

HY-B0512S1

Sulfamerazine-13C6

Sulfamerazine- ¹³C₆ (RP2632- ¹³C₆) is ¹³C labeled Sulfamerazine (HY-B0512). Sulfamerazine (RP-2632) is a sulfonamide antibacterial. Sulfamerazine, the monomethyl derivative of sulfadiazine, is 2-sulfanilamido-4-methylpyrimidine. Sulfamerazine is a sulfonamide drug that inhibits bacterial synthesis of dihydrofolic acid by competing with para-aminobenzoic acid (PABA) for binding to dihydropteroate synthesizes.

HY-A0130S

Sulfalene-13C6
Sulfalene- ¹³C₆ is the ¹³C₆ labeled Sulfalene. Sulfalene (Sulfametopyrazine) is an antimalarial agent. Sulfalene is also a long-acting sulfonamide antibacterial .

HY-B1781S

Sulfachloropyridazine-13C6
Sulfachloropyridazine- ¹³C₆ is the ¹³C₆ labeled Sulfachloropyridazine. Sulfachloropyridazine is a broad spectrum sulfonamide used against both Gram-positive and Gram-negative aerobic bacteria.

HY-W719074

Sulfisomidin-d4
Sulfisomidin-d₄ (Sulfaisodimidine-d₄) is deuterium labeled Sulfisomidin. Sulfisomidin (Sulfaisodimidine) is an orally active short-acting sulfonamide antibacterial. Sulfisomidin can be used for the research of lower urinary tract infections .

HY-B0439S

Sulfadoxine-d4
Sulfadoxine-d₄ is the deuterium labeled Sulfadoxine. Sulfadoxine(Sulphadoxine) is a long acting sulfonamide that is used, usually in combination with other agents, for respiratory, urinary tract and malarial infections. Sulfadoxine inhibits HIV replication in peripheral blood mononuclear cells.

HY-U00131S

Sulfabrom-d4
Sulfabrom-d₄ (N 3517-d₄) is is the deuterium labeled Sulfabrom (HY-U00131). Sulfabrom is a long-acting Sulfonamide that is used for the treatment of coccidiosis and various bacterial infections in the poultry, swine and cattle .

HY-N7123S1

Sulfacetamide-13C6
Sulfacetamide- ¹³C₆ (Sulphacetamide ¹³C₆) is the ¹³C₆ labeled Sulfacetamide (HY-N7123). Sulfacetamide (Sulphacetamide) is a sulfonamide antibiotic that can be used for the study of ocular infections. Sulfacetamide has antifungal and antibacterial activities .

HY-B0946S1

Sulfamonomethoxine-d3
Sulfamonomethoxine-d₃ is the deuterium labeled Sulfamonomethoxine (HY-B0946). Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .

HY-W698694

N4-Acetylsulfamerazine-d4
N4-Acetylsulfamerazine-d₄ (Acetylsulfamerazine-d₄; Sulfamelazine-d₄) is the deuterium labeled N4-Acetylsulfamerazine (HY-W031230). N4-Acetylsulfamerazine is a sulfonamides derivative .

HY-B0946S3

Sulfamonomethoxine-d3-1
Sulfamonomethoxine-d₃-1 is the deuterium labeled Sulfamonomethoxine (HY-B0946). Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .

HY-B0946S2

Sulfamonomethoxine-13C6
Sulfamonomethoxine- ¹³C₆ is the ¹³C₆ labeled Sulfamonomethoxine (HY-B0946). Sulfamonomethoxine is an orally active sulfonamide antibiotic for veterinary use. Sulfamonomethoxine is also an inhibitor of dihydropteroate synthetase, which can block the synthesis of folic acid. Sulfamonomethoxine has antibacterial activity .

HY-B0213S

Sulfameter-d4
Sulfameter-d₄ (Sulfametoxydiazine-d₄) is the deuterium labeled Sulfameter (HY-B0213) . Sulfameter (Sulfametoxydiazine) is an orally active long-acting sulfonamide antibiotic. Sulfameter is active against both Gram-positive and Gram-negative bacteria. Sulfameter can be used for the research of diseases such as respiratory and urinary tract infections .

HY-B0213S1

Sulfameter-13C6
Sulfameter- ¹³C₆ (Sulfametoxydiazine- ¹³C₆) is the ¹³C₆ labeled Sulfameter (HY-B0213). Sulfameter (Sulfametoxydiazine) is an orally active long-acting sulfonamide antibiotic. Sulfameter is active against both Gram-positive and Gram-negative bacteria. Sulfameter can be used for the research of diseases such as respiratory and urinary tract infections .

HY-W748688

N4-Acetylsulfamethoxazole-13C6
N4-Acetylsulfamethoxazole- ¹³C₆ (Acetylsulfamethoxazole- ¹³C₆) is the ¹³C-labeled N4-Acetylsulfamethoxazole (HY-W013266). N4-Acetylsulfamethoxazole (Acetylsulfamethoxazole) is a metabolite of?Sulfamethoxazole (HY-B0322). Sulfamethoxazole is a sulfonamide bacteriostatic antibiotic, used for bacterial infections .

HY-B0688S3

Dapsone-15N2

Dapsone- ¹⁵N₂ (4,4′-Diaminodiphenyl sulfone- ¹⁵N₂) is ¹⁵N labeled Dapsone. Dapsone (4,4′-Diaminodiphenyl sulfone) is an orally active and blood-brain penetrant sulfonamide antibiotic with bacteriostatic, antimycobacterial and antiprotozoal activities . Dapsone?exerts effective antileprosy activity?and inhibits folate synthesis in cell extracts of?M. leprae. Dapsone is used for dermatologic disorder research, including leprosy, dermatitis herpetiformis, acne vulgaris et al .

HY-W700530

4-Chlorobenzene-2,3,5,6-d4-sulfonamide
4-Chlorobenzene-2,3,5,6-d₄-sulfonamide is the deuterium labeled 4-Chlorobenzenesulfonamide (HY-W020220).

HY-W705409

1-(N,N-Dimethylsulfamoyl)-1H-imidazole-15N2
1-(N,N-Dimethylsulfamoyl)-1H-imidazole- ¹⁵N₂ is the ¹⁵N-labeled N,N-Dimethyl-1H-imidazole-1-sulfonamide (HY-W016732).

HY-W042301S

Xipamide-d6
Xipamide-d₆ is the deuterium labeled Xipamide. Xipamide is a sulfonamide-based diuretic. Xipamide is an antihypertensive agent able to selectively inhibit the anion exchanger (AE) .

HY-D0017S1

Dansyl chloride-13C2
Dansyl chloride- ¹³C₂ is the ¹³C labeled Dansyl chloride (HY-D0017) . Dansyl chloride is a reagent that produces stable blue or blue-green fluorescent sulfonamide adducts in the reaction of aliphatic and aromatic amines with primary amino groups, and is widely used for modified amino acids, protein sequencing and amino acid analysis.

Cat. No.	Product Name		Classification

HY-W027544S1

Dansyl propargylamine-d6 5-(Dimethylamino)-N-(prop-2-yn-1-yl)naphthalene-1-sulfonamide-d₆		Labeling and Fluorescence Imaging Alkynes
Dansyl propargylamine-d₆ (5-(Dimethylamino)-N-(prop-2-yn-1-yl)naphthalene-1-sulfonamide-d₆) is the deuterium labeled Dansyl propargylamine .

Inquiry Online

Your information is safe with us. * Required Fields.

MCE Japan Authorized Agent ナミキ商事株式会社コスモ・バイオ株式会社重松貿易株式会社
Salutation			Country or Region *
Applicant Name *			Organization Name *
Department *
Email Address *			Product Name *
Cat. No.			Requested quantity *
Phone Number *
Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent:

Sulfonamides

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

NaturalProducts

Isotope-Labeled Compounds

Click Chemistry

Natural
Products