2 Results for "

TGF-β2-IN-1

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "TGF-β2-IN-1" in MCE Product Catalog:

Cat. No.: HY-175205
Target:  

TGF-beta/Smad

Research Areas:  

Cancer

TGF-β2-IN-1 is a selective TGF-β2 inhibitor. TGF-β2-IN-1 exhibits potent antiproliferative effects on HCT-116, Caco-2 and HT-29 with IC50 values of 6.84, 10.21, and 9.47 μM, respectively. TGF-β2-IN-1 inhibits TGF-β2 signaling in a dose-dependent manner by suppressing both receptor and cytokine expression.TGF-β2-IN-1 can be used for the study of colorectal cancer .
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2
2 Cited Publications
Cat. No.: HY-P99020
CAS No.: 948564-73-6
Synonyms: GC1008

Target:  

TGF-beta/Smad

Research Areas:  

Inflammation/Immunology Cancer

Fresolimumab (GC1008) is a human monoclonal antibody against TGF-β that neutralizes all mammalian active subtypes of TGF-β. The binding affinity of Fresolimumab to TGF-β2 is 1.8 nM. Fresolimumab improves Bleomycin (HY-108345)-induced acute lung injury. Fresolimumab radiolabeled with 89Zr can be used for PET analysis of TGF-β expression, antibody uptake and organ distribution. Fresolimumab can be used in the study of cancer, osteogenesis imperfecta, fibrosis and kidney disease .
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