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Valproic acid sodium (2:1)

" in MedChemExpress (MCE) Product Catalog:
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Valproic acid sodium (2:1)
Valproic acid sodium (2:1)
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Cat. No.: HY-10585B
CAS No.: 76584-70-8
Synonyms: sodium Valproate (2:1); VPA sodium (2:1); 2-Propylpentanoic acid sodium (2:1)
Category:  

Infection Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields Cancer

Target:  

HDAC Autophagy Mitophagy HIV Notch Apoptosis Endogenous Metabolite

Valproic acid (VPA) sodium (2:1) is an orally active HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid sodium (2:1) activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium (2:1) is used in the treatment of epilepsy, bipolar disorder, metabolic disease, HIV infection and prevention of migraine headaches .
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