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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
24 Results for "
Wee1 kinase
" in MedChemExpress (MCE) Product Catalog:
Products (24)
24 Results for "Wee1 kinase" in MCE Product Catalog:
1
1 Cited Publications
WEE1-IN-4 (compound 15) is a pyrrolocarbazole-1,3(2H,6H)-dione derivative and Wee1 kinase inhibitor with an IC50 value of 11 nM.WEE1-IN-4 can be used for the research of cancer .
Cat. No.: HY-175749
CAS No.: 3025467-07-3
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BMS-986463, a CRBN E3 ligase modulator (CELMoD), is a WEE1 kinase molecular glue degrader. BMS-986463 significantly inhibits tumor regression and reduces the level of phospho-CDK2. BMS-986463 can be used for advanced malignant solid tumors like non-small cell lung cancer (NSCLC) research .
Cat. No.: HY-168654
CAS No.: 3090685-34-7
WEE1 degrader 1 (Compound 10) is a CRBN-dependent molecular glue degrader of WEE1 and casein kinase 1α (CK1α) with sub-2 nM DC50 values for both targets. WEE1 degrader 1 can be used for the research of acute lymphoblastic leukemia, acute monocytic leukemia, acute promyelocytic leukemia, colorectal adenocarcinoma, diffuse large b cell lymphoma .
Research Areas:
Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
FMF-06-098-1 is a multi-target kinase PROTAC degrader. FMF-06-098-1 can be used to target degradation kinases which degrades AAK1, AΒL2, AURKA, AURKB, BUBIB, CDC7, CDK1, CDK12, CDK13, CDK2, CDK4, CDk6, CDK7, CDK9, CHEK1, CSNKID, EPHA1, PER, FGFR1, GAK, IRAK4, ITK, LIMK2, MAP4K2, MAP4K3, MAPK6, MAPK7, MARK4, MELK, PKN3, PLK4, PRKAA1, PTK2, PTK6, RPS6KA4, S1K2, STK35, TNK2, UHMK1, ULK1, and WEE1 .
Cat. No.: HY-18961
CAS No.: 622864-54-4
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PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4 .
Cat. No.: HY-161880
CAS No.: 2226938-19-6
WEE1-IN-10 (compound 77) is a Wee1 kinase inhibitor. WEE1-IN-10 shows inhibitory activity on LOVO cell growth, with an IC50 of 0.524 μM. WEE1-IN-10 can be used for the research of diseases caused by abnormal activity of Wee1 .
Cat. No.: HY-W070306
CAS No.: 1207836-10-9
Cat. No.: HY-178190
WEE1-IN-13 (Compound 10) is a highly selective WEE1 kinase inhibitor (IC50=0.7 nM). WEE1-IN-13 abrogates the G2/M checkpoint and induces tumor cell apoptosis. WEE1-IN-13 is promising for research of solid tumors (e.g., non-small cell lung cancer, ovarian cancer) .
Cat. No.: HY-174448
CAS No.: 3069940-37-7
WEE1-IN-12 (Compound 87) is a Wee1 kinase inhibitor with an IC50 of 2.0 nM. WEE1-IN-12 can inhibit the proliferation of HT29 cells (IC50: 1.07 μM), and when used in combination with Gemcitabine (HY-17026), the effect is better (IC50: 0.34 μM). WEE1-IN-12 can be used in the research of tumors such as colon cancer .
Cat. No.: HY-178150
CAS No.: 2803921-87-9
WEE1-IN-14 (Compound 14) is a selective WEE1 inhibitor (IC50: 0.5 nM in L-RB-FEP calculations, 1.0 nM in ADP-Glo kinase assay). Inhibition of Wee1 in cancer cells disrupts the G2-M checkpoint, removes the regulatory controls on the cell cycle, and leads to early onset of mitotic failure followed by apoptosis of tumor cells. Therefore, WEE1-IN-14 is a useful tool for studying cancer biology .
Cat. No.: HY-108343R
CAS No.: 622855-37-2
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WEE1-IN-4 (Standard) is the analytical standard of WEE1-IN-4 (HY-108343). This product is intended for research and analytical applications. WEE1-IN-4 (Compound 15) is a potent checkpoint Wee1 Kinase inhibitor with an IC50 of 0.011 μM. Wee1 inhibitors can abrogate the G2/M checkpoint .
Cat. No.: HY-P701727
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Wee1; Wee1 G2 Checkpoint kinase; Wee1‑Like Protein kinase; Wee1A; Wee1A kinase; Wee1hu; Non‑Specific Protein‑Tyrosine kinase; Wee1+ (S. Pombe) Homolog; Wee1 Homolog (S. Pombe); Protein kinase; Wee1+ Homolog; Wee1 Homolog
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Cat. No.: HY-P701726
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Wee1; Wee1 G2 Checkpoint kinase; Wee1‑Like Protein kinase; Wee1A; Wee1A kinase; Wee1hu; Non‑Specific Protein‑Tyrosine kinase; Wee1+ (S. Pombe) Homolog; Wee1 Homolog (S. Pombe); Protein kinase; Wee1+ Homolog; Wee1 Homolog
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Cat. No.: HY-P705896
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Wee1; Wee1 G2 Checkpoint kinase; Wee1‑Like Protein kinase; Wee1A; Wee1A kinase; Wee1hu; Non‑Specific Protein‑Tyrosine kinase; Wee1+ (S. Pombe) Homolog; Wee1 Homolog (S. Pombe); Protein kinase; Wee1+ Homolog; Wee1 Homolog
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Cat. No.: HY-P706113
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Wee1; Wee1 G2 Checkpoint kinase; Wee1‑Like Protein kinase; Wee1A; Wee1A kinase; Wee1hu; Non‑Specific Protein‑Tyrosine kinase; Wee1+ (S. Pombe) Homolog; Wee1 Homolog (S. Pombe); Protein kinase; Wee1+ Homolog; Wee1 Homolog
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Cat. No.: HY-182433
CAS No.: 1847445-87-7
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CJM061 is a WEE1 kinase inhibitor with a target IC50 of 2.8 nM. CJM061 acts as a sensitizer and exhibits synergistic effects with Cisplatin (HY-17394) in medulloblastoma cells. CJM061 can be used for the research of medulloblastoma .
Cat. No.: HY-P87147
Synonyms: DKFZp686I18166 antibody; EC 2.7.10.2 antibody; FLJ16446 antibody; MGC105683 antibody; OTTHUMP00000231338 antibody; OTTHUMP00000231339 antibody; Wee 1 antibody; Wee 1 homolog 1 (S. pombe) antibody; Wee1 antibody; Wee1 homolog (S. pombe) antibody; DKFZp686I18166 antibody; EC 2.7.10.2 antibody; FLJ16446 antibody; MGC105683 antibody; OTTHUMP00000231338 antibody; OTTHUMP00000231339 antibody; Wee 1 antibody; Wee 1 homolog 1 (S. pombe) antibody; Wee1 antibody; Wee1 homolog (S. pombe) antibody; Wee1 homolog antibody; Wee1 homolog S. pombe antibody; Wee1 like protein kinase antibody; Wee1 tyrosine kinase antibody; Wee1+ homolog antibody; Wee1+ S. pombe homolog antibody; Wee1, S. pombe, homolog of antibody; Wee1, somatic antibody; Wee1-like protein kinase antibody; Wee1_HUMAN antibody; Wee1A antibody; Wee1A kinase antibody; Wee1hu antibody;
Cat. No.: HY-P706186
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: Wee1-like protein kinase; Wee1A kinase
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
