66 Results for "

acylated

" in MedChemExpress (MCE) Product Catalog:
Products (66)

66 Results for "acylated" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-P3462
CAS No.: 1415456-99-3
Target:  

CGRP Receptor

Research Areas:  

Metabolic Disease

Cagrilintide is an investigational novel long-acting acylated amylin analogue, acts as nonselective amylin receptors (AMYR) and calcitonin G protein-coupled receptor (CTR) agonist. Cagrilintide induces significant weight loss and reduces food intake. Cagrilintide has the potential for the research of obesity .
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3
3 Cited Publications
Cat. No.: HY-P3462A
Target:  

CGRP Receptor

Research Areas:  

Metabolic Disease

Cagrilintide acetate is a non-selective AMYR/CTR agonist and long-acting acylated amylase analogue. Cagrilintide acetate causes a reduction in food intake and significant weight loss in a dose-dependent manner. Cagrilintide acetate can be used in obesity studies .
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1
1 Cited Publications
Cat. No.: HY-N6980
CAS No.: 202657-55-4
Licorice glycoside C2 is an acylated flavonoid glycoside found in the underground part of Glycyrrhiza uralensis .
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1
1 Cited Publications
Cat. No.: HY-N2459
CAS No.: 134-01-0
Synonyms: YGM-6 chloride
Peonidin (YGM-6) chloride is an anthocyanin compound found in plants such as grapes and purple-fleshed sweet potatoes. Peonidin chloride alone exerts no stable inhibitory effect on LPS (HY-D1056)-mediated inflammatory gene expression. The acylated form of Peonidin chloride exhibits antimutagenic activity .
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Cat. No.: HY-P4146
CAS No.: 2805997-46-8
Synonyms: BI 456906
Survodutide (BI 456906) is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .
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Cat. No.: HY-79647
CAS No.: 82911-69-1
Synonyms: N-(Fmoc-oxy)succinimide
Fmoc-OSu (N-(Fmoc-oxy)succinimide) is an acylating agent that targets amino groups (-NH2). It can selectively protect the amino groups of amino acids by covalently binding with primary or secondary amines through nucleophilic substitution reactions. Fmoc-OSu forms a stable amide bond with the amino group to avoid side reactions of the amino group in peptide synthesis. It can also be used as a fluorescent labeling reagent to react with glycosylamines for efficient labeling of N-sugar chains. Fmoc-OSu can be used as an Fmoc protection strategy in peptide synthesis, and as a fluorescent labeling and analysis method for N-sugar chains .
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Cat. No.: HY-Y0095
CAS No.: 107-36-8
Synonyms: 2-Hydroxyethanesulfonic acid
Isethionic acid (2-Hydroxyethanesulfonic acid) is an endogenous mammalian Taurine (HY-B0351) metabolite. Isethionic acid forms covalent ester linkages with cholic acid. It acts as a larval settlement inhibitor for Balanus amphitrite with larval toxicity. Isethionic acid enables the low-temperature synthesis of highly hygroscopic water-soluble sulfonates, and its acylated derivatives serve as acidic wetting solubilizers. It is used in studies related to hepatic bile acid metabolism, biological control and organic synthesis .
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Cat. No.: HY-164899
CAS No.: 2765091-45-8
Synonyms: 2-aminopyridine-3-carboxylic acid imidazolide
Target:  

DNA/RNA Synthesis

Research Areas:  

Infection

2A3 (2-aminopyridine-3-carboxylic acid imidazolide) is a covalent probe reagent for Selective 2'-Hydroxyl Acylation analyzed by Primer Extension (SHAPE) that targets the RNA ribose 2'-OH group. 2A3 efficiently permeates the biological membranes of Gram-negative bacteria, Gram-positive bacteria, and mammalian cells. 2A3 exhibits no base bias and specifically labels conformationally flexible, unpaired regions within RNA. 2A3 forms covalent adducts by acylating the 2'-OH groups of flexible RNA residues. When combined with SHAPE-MaP (mutational profiling) sequencing technology, these modification sites are converted into detectable mutational signals, thereby accurately reflecting local RNA backbone flexibility and base-pairing status. 2A3 is primarily utilized in molecular biology and transcriptomics research, including the resolution of RNA structuromes in living cells, the study of RNA folding regulatory mechanisms, and the investigation of non-coding RNA functions .
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Cat. No.: HY-162350
CAS No.: 3057216-63-1
Research Areas:  

Cancer

TDI-11055 is a selective and orally active eleven-nineteen leukemia (ENL) inhibitor, which displaces ENL from chromatin by blocking its YEATS domain interaction with acylated histones. TDI-11055 inhibits ENL and AF9 YEATS domains with IC50 values of 50 nM and 70 nM, respectively, and no activity against GAS41 or YEATS2. TDI-11055 decreases chromatin occupancy of ENL-associated complexes, impairs transcription elongation, suppresses key oncogenic gene expression programs, and induces differentiation. TDI-11055 can be used for the research of acute myeloid leukemia .
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Cat. No.: HY-W402064
CAS No.: 16265-37-5
Research Areas:  

Others

N-Acetyladenosine is an adenosine analog and an adenosine N 6-acylated derivative. N-Acetyladenosine can be produced via the heterolytic reaction between adenosine and diacetyl peroxide .
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Cat. No.: HY-Y1173
CAS No.: 1562-00-1
Synonyms: 2-Hydroxyethanesulfonic acid sodium; Sodium isethionate
Isethionic acid sodium salt (2-Hydroxyethanesulfonic acid sodium; Sodium isethionate) is an endogenous mammalian Taurine (HY-B0351) metabolite. Isethionic acid sodium salt forms covalent ester linkages with cholic acid. It acts as a larval settlement inhibitor for Balanus amphitrite with larval toxicity. Isethionic acid sodium salt enables the low-temperature synthesis of highly hygroscopic water-soluble sulfonates, and its acylated derivatives serve as acidic wetting solubilizers. It is used in studies related to hepatic bile acid metabolism, biological control and organic synthesis .
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Cat. No.: HY-W001578
CAS No.: 4942-47-6
1-Adamantaneacetic acid is an aliphatic carboxylic acid that can be used as an acylating agent, commonly found in chemical synthesis .
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Cat. No.: HY-W015800
CAS No.: 2185-03-7
Target:  

Drug Intermediate

Research Areas:  

Others

L-Homoserine lactone hydrochloride is the core structural unit of the bacterial quorum-sensing signal molecule N-acyl-L-homoserine lactone (AHLs). As an important intermediate, L-Homoserine lactone hydrochloride acylated derivatives have potent immunosuppressive activity .
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Cat. No.: HY-W001957
CAS No.: 3128-06-1
Synonyms: 4-Acetylbutyric acid; 5-Oxohexanoic acid; NSC-5281
Target:  

Drug Intermediate HIV

Research Areas:  

Infection

Glurate (4-Acetylbutyric acid) is an acylating agent. Glurate can be used in the development of antiviral compounds, especially those targeting retroviruses such as herpes virus and HIV. Glurate can be used in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid .
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Cat. No.: HY-N16520
CAS No.: 157407-84-6
Kaempferol 3-O-β-D-glucopyranoside 6′′-(3-hydroxy-3-methylglutarate) is an acylated flavonol glycoside. Kaempferol 3-O-β-D-glucopyranoside 6′′-(3-hydroxy-3-methylglutarate) can be isolated from 10-year-old callus cultures of Mexican lime .
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Cat. No.: HY-W243002
CAS No.: 51524-71-1
Target:  

Bacterial

Research Areas:  

Infection

Acetyl-L-homoserine lactone is a member of the family of N-acylated homoserine lactones (HSLs). Acetyl-L-homoserine lactone is a polar mediator of cell-cell interactions in bacterial biofilms .
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Cat. No.: HY-128737
CAS No.: 1824-94-8
Purity:  ≥95.0%
Methyl β-D-Galactopyranoside is a monosaccharide methyl glycoside that serves as the parent scaffold for the preparation of acylated MGP derivatives. Methyl β-D-Galactopyranoside is used in studies related to carbohydrate chemistry and glycoside derivatives .
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Cat. No.: HY-P4146A
Synonyms: BI 456906 TFA
Target:  

GLP Receptor GCGR

Research Areas:  

Metabolic Disease

Survodutide (BI 456906) TFA is a potent, selective glucagon receptor/GLP-1 receptor (GCGR/GLP-1R) dual agonist with EC50s of 0.52 nM and 0.33 nM in CHO-K1 cells, respectively. Survodutide TFA, a 29-amino-acid peptide, is a potent acylated peptide containing a C18 fatty acid. Survodutide TFA has robust anti-obesity efficacy achieved by increasing energy expenditure and decreasing food intake .
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Cat. No.: HY-W127407
CAS No.: 201738-25-2
Research Areas:  

Others

Glycerophospho-N-Arachidonoyl Ethanolamine is a N-acylated ethanolamines (NAEs). Most NAEs are naturally occurring lipids with diverse biological activities. Different types of NAE can be derived from glycerophosphate-linked precursors through the activity of glycerophosphodiesterase 1 (GDE1). Glycerophosphate-N-Arachidonoyl Ethanolamine is the precursor of Anandamide (AEA), also known as Anandamide. AEA is an endocannabinoid neurotransmitter that binds to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM compared to 46 nM for δ9-THC.
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Cat. No.: HY-W127393
CAS No.: 177158-21-3
Quorum sensing is a regulatory system used by bacteria to control gene expression in response to increased cell density. This regulatory process manifests itself in a variety of phenotypes, including biofilm formation and virulence factor production. Coordinated gene expression is achieved through the production, release and detection of small diffusible signaling molecules called autoinducers. N-acylated homoserine lactones (AHLs) comprise a class of such autoinducers, each of which generally consists of a fatty acid coupled to a homoserine lactone (HSL). Modulation of bacterial quorum-sensing signaling systems to suppress pathogenesis represents a new approach to antimicrobial research for infectious diseases. AHLs differ in acyl length (C4-C18), C3 substitution (hydrogen, hydroxyl, or oxo group), and the presence or absence of one or more carbon-carbon double bonds in the fatty acid chain. These differences confer signaling specificity through the affinity of the LuxR family of transcriptional regulators. C9-HSL is a rare odd-numbered acyl carbon chain produced by wild-type Erwinia carotovora strain SCC 3193 grown in nutrient-rich Luria-Bertani broth (LB) medium.
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