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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
182 Results for "
allergic rhinitis
" in MedChemExpress (MCE) Product Catalog:
Products (182)
182 Results for "allergic rhinitis" in MCE Product Catalog:
28
28 Publications Verification
Research Areas:
SKF-96365 hydrochloride is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 hydrochloride reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 hydrochloride inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 hydrochloride inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 hydrochloride induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 hydrochloride alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 hydrochloride reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 hydrochloride inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 hydrochloride is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .
28
28 Publications Verification
Cat. No.: HY-125942
CAS No.: 162849-90-3
Research Areas:
SKF-96365 is a TRPC channel antagonist and store-operated calcium entry (SOCE) inhibitor. SKF-96365 reduces calcium ion influx by inhibiting the activity and expression of TRPC6, STIM1 and Orai1. SKF-96365 inhibits voltage-gated sodium current (cardiac INa/NaV1.5) and slows myocardial conduction. SKF-96365 inhibits phosphorylation/activation of CaMKIIγ and suppresses the downstream AKT signaling pathway. SKF-96365 induces G2/M phase cell cycle arrest, apoptosis and cytoprotective autophagy in colorectal cancer cells. SKF-96365 alleviates allergic rhinitis symptoms by reducing inflammatory cytokine levels. SKF-96365 reduces intracellular calcium overload, inhibits Homer1 expression, prevents nuclear damage and suppresses apoptosis. SKF-96365 inhibits the growth of colorectal cancer xenografts in nude mice . SKF-96365 is applicable to research related to allergic rhinitis, colorectal cancer, Parkinson's disease, persistent spontaneous nociception and hyperalgesia .
28
28 Publications Verification
Cat. No.: HY-P70568
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL13; MGC116789; Interleukin 13; ALRH; IL-13; BHR1; Interleukin-13; Bronchial Hyperresponsiveness-1 (Bronchial Asthma); P600; allergic rhinitis; MGC116786; NC30; MGC116788
26
26 Cited Publications
Cat. No.: HY-P70460
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL13; MGC116789; Interleukin 13; ALRH; IL-13; BHR1; Interleukin-13; Bronchial Hyperresponsiveness-1 (Bronchial Asthma); P600; allergic rhinitis; MGC116786; NC30; MGC116788
17
17 Cited Publications
Cat. No.: HY-P72795
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL13; MGC116789; Interleukin 13; ALRH; IL-13; BHR1; Interleukin-13; Bronchial Hyperresponsiveness-1 (Bronchial Asthma); P600; allergic rhinitis; MGC116786; NC30; MGC116788
14
9
5
5 Cited Publications
Cat. No.: HY-W250978
CAS No.: 9006-59-1
Ovalbumin, low endotoxin (HY-W250978A) is recommended for model establishment .
5
5 Cited Publications
Cat. No.: HY-B0801
CAS No.: 83799-24-0
Synonyms: MDL-16455; Terfenadine carboxylate
Target:
Research Areas:
Fexofenadine (MDL-16455) is an orally active and nonsedative H1 receptor antagonist. Fexofenadine can be used in allergic rhinitis and chronic idiopathic urticarial research .
5
5 Cited Publications
Cat. No.: HY-B0801A
CAS No.: 153439-40-8
Synonyms: MDL-16455 hydrochloride; Terfenadine carboxylate hydrochloride
Target:
Research Areas:
Fexofenadine (MDL-16455) hydrochloride is an orally active and nonsedative H1 receptor antagonist. Fexofenadine hydrochloride can be used in allergic rhinitis and chronic idiopathic urticarial research .
5
Category:
Plants Trifolium pratense Linn. Flavonoids Leguminosae Phenols Polyphenols Disease Research Fields Glycyrrhiza uralensis Fisch. Inflammation/Immunology Isoflavones
Target:
3
3 Cited Publications
Cat. No.: HY-B0462
CAS No.: 79307-93-0
Target:
Research Areas:
Infection Metabolic Disease Inflammation/Immunology Endocrinology
Azelastine hydrochloridem, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine hydrochloride can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2 .
3
3 Cited Publications
Cat. No.: HY-B0462A
CAS No.: 58581-89-8
Target:
Research Areas:
Infection Metabolic Disease Inflammation/Immunology Endocrinology
Azelastine, an antihistamine, is a potent and selective histamine 1 (H1) antagonist. Azelastine can be used for the research of allergic rhinitis, asthma, diabetic hyperlipidemic and SARS-CoV-2 .
3
3 Cited Publications
Target:
Research Areas:
hPGDS-IN-1 (Compound 2 ) is an hPGDS inhibitor with an IC50 of 12 nM (as measured by fluorescence polarization assay or EIA). hPGDS-IN-1 can be used in the research of allergic rhinitis and spinal cord neurons .
3
3 Cited Publications
Cat. No.: HY-17042
CAS No.: 83881-51-0
Target:
3
Target:
Research Areas:
Cetirizine dihydrochloride, a second-generation antihistamine and the carboxylated metabolite of hydroxyzine, is a specific, orally active and long-acting histamine H1-receptor antagonist. Cetirizine dihydrochloride marks antiallergic properties and inhibits eosinophil chemotaxis during the allergic response .
3
3 Cited Publications
Cat. No.: HY-P7076A
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL13; MGC116789; Interleukin 13; ALRH; IL-13; BHR1; Interleukin-13; Bronchial Hyperresponsiveness-1 (Bronchial Asthma); P600; allergic rhinitis; MGC116786; NC30; MGC116788
2
2 Cited Publications
Synonyms: UR-12592 Fumarate
Target:
Research Areas:
Rupatadine (UR-12592) Fumarate is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine Fumarate can be used for the research of allergic rhinitis and urticaria .
2
Research Areas:
Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research .
2
Target:
Research Areas:
Rupatadine (UR-12592) is a potent, orally active and long-lasting dual PAF/H1 antagonist, with Kis of 0.55 μM and 0.1 μM, respectively. Rupatadine can be used for the research of allergic rhinitis and urticaria .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
