980-71-2
980-71-2
Chemical Structure
Brompheniramine maleate
Synonym(s): (±)-Brompheniramine maleate
- CAS No.: 980-71-2
- Formula:C20H23BrN2O4
- Molecular Weight:435.31
IUPAC Name: 3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate
InChIKey: SRGKFVAASLQVBO-BTJKTKAUSA-N
SMILES: O=C(O)/C=C\C(O)=O.CN(C)CCC(C1=CC=CC=N1)C2=CC=C(Br)C=C2
Biological Activity: Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Brompheniramine maleate | 99.93% | Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research. | ||||||||||||||||||||
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Brompheniramine maleate (Standard) | ≥98% | Brompheniramine (maleate) (Standard) is the analytical standard of Brompheniramine (maleate). This product is intended for research and analytical applications. Brompheniramine ((±)-Brompheniramine) maleate is a potent and orally active antihistamine of the alkylamine class. Brompheniramine maleate is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine maleate can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine maleate has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research. | ||||||||||||||||||||
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(R)-(-)-Chlorpheniramine maleate | (R)-(-)-Chlorpheniramine maleate is an enantiomer of Chlorpheniramine maleate (HY-B0286A). Chlorpheniramine maleate is a H1 antihistamines. (R)-(-)-Chlorpheniramine maleate can be used for allergic diseases such as rhinitis and urticaria research. | |||||||||||||||||||||
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(-)-Brompheniramine | 99.82% | (-)-Brompheniramine is a H1 receptor antagonist with antiallergic activity. | ||||||||||||||||||||
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Dexbrompheniramine | 99.93% | Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine can be used in the research of chronic cough and related pathological mechanisms. | ||||||||||||||||||||
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Dexbrompheniramine maleate | 98.52% | Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) maleate is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine maleate exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine maleate with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine maleate alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine maleate can be used in the research of chronic cough and related pathological mechanisms. | ||||||||||||||||||||
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Chlorpheniramine maleate (Standard) | 99.37% | Chlorpheniramine (maleate) (Standard) is the analytical standard of Chlorpheniramine (maleate). This product is intended for research and analytical applications. Chlorpheniramine maleate is a histamine H1 receptor antagonist with an IC50 of 12 nM. | ||||||||||||||||||||
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Chlorpheniramine-d6 maleate | Chlorpheniramine-d6 (maleate) is the deuterium labeled Chlorpheniramine maleate. | |||||||||||||||||||||
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Brompheniramine (Standard) | ≥98% | Brompheniramine (Standard) is the analytical standard of Brompheniramine. This product is intended for research and analytical applications. Brompheniramine ((±)-Brompheniramine) is a potent and orally active antihistamine of the alkylamine class. Brompheniramine is a selective histamine H1 receptor antagonist with a Kd of 6.06 nM. Brompheniramine can block the hERG channels, calcium channels, and sodium channels with IC50s of 0.90 μM, 16.12 μM and 21.26 μM, respectively. Brompheniramine has anticholinergic, antidepressant and anesthetic properties and can be used for allergic rhinitis research. | ||||||||||||||||||||
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Pheniramine maleate | 99.94% | Pheniramine (Prophenpyridamine; Tripoton) maleate is a first-generation histamine H1 receptor antagonist, acts on the central nervous system (CNS) with sedative and hypnotic effect. Pheniramine maleate displays antitumor effect and induces leukemia cells apoptosis. Pheniramine maleate is also a safe and effective local agent that can suppress or relieve pain, with antipruritic effects. | ||||||||||||||||||||
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Dexchlorpheniramine maleate (Standard) | ≥98% | Dexchlorpheniramine (maleate) (Standard) is the analytical standard of Dexchlorpheniramine (maleate). This product is intended for research and analytical applications. Dexchlorpheniramine maleate is an antihistamine with anticholinergic properties used in the study of allergic diseases. | ||||||||||||||||||||
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3-(4-Chlorophenyl)-N-methyl-3-(pyridin-2-yl)propan-1-amine maleate (Chlorphenamine Impurity) (Standard) | 99.59% | 3-(4-Chlorophenyl)-N-methyl-3-(pyridin-2-yl)propan-1-amine maleate (Chlorphenamine Impurity) (Standard) is the analytical standard of 3-(4-Chlorophenyl)-N-methyl-3-(pyridin-2-yl)propan-1-amine maleate (Chlorphenamine Impurity). This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Chong-Chi Chiu, et al. Subcutaneous brompheniramine for cutaneous analgesia in rats. Eur J Pharmacol. 2019 Oct 5;860:172544. [Content Brief]
- [2]. B Cusack, et al. Binding of antidepressants to human brain receptors: focus on newer generation compounds. Psychopharmacology (Berl). 1994 May;114(4):559-65. [Content Brief]
- [3]. Shin WH, Kim KS, Kim EJ. Electrophysiological effects of brompheniramine on cardiac ion channels and action potential. Pharmacol Res. 2006 Dec;54(6):414-20. [Content Brief]
- [4]. Yasuda SU, Yasuda RP. Affinities of brompheniramine, chlorpheniramine, and terfenadine at the five human muscarinic cholinergic receptor subtypes. Pharmacotherapy. 1999 Apr;19(4):447-51. [Content Brief]
