Dexbrompheniramine maleate  (Synonyms: (+)-Brompheniramine maleate; (S)-Brompheniramine maleate)

Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) maleate is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine maleate exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine maleate with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine maleate alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine maleate can be used in the research of chronic cough and related pathological mechanisms^[1][2][3].

Dexbrompheniramine (1 mg/kg; i.p.; single dose; co-administered with 16 mg/kg cimetidine) maleate completely abolishes histamine-induced drinking behavior in rats, but does not alter serotonin-induced drinking behavior in rats^[1].
Dexbrompheniramine (1 mg/kg; i.p.; single administration; 10 min before the start of the test) maleate alone does not alter prandial drinking or sham-feeding behavior in preabsorptive rats, but when co-administered with 16 mg/kg cimetidine, it completely abolishes the drinking response without affecting sham-feeding behavior^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

435.31

C₂₀H₂₃BrN₂O₄

2391-03-9

CN(C)CC[C@H](C1=CC=CC=N1)C2=CC=C(C=C2)Br.O=C(O)/C=C\C(O)=O

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• [1]. Kraly FS, et al. Histamine and serotonin independently elicit drinking in the rat. Physiol Behav. 1985;34(6):963-967.  [Content Brief]

  [2]. Singh U, et al. Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach[J]. Clinical and Experimental Allergy, 2025, 55(3): 247.

  [3]. Kraly FS, et al. Preabsorptive pregastric vagally mediated histaminergic component of drinking elicited by eating in the rat. Behav Neurosci. 1984;98(2):349-355.  [Content Brief]