2391-03-9
Chemical Structure
Dexbrompheniramine maleate
Synonym(s): (+)-Brompheniramine maleate; (S)-Brompheniramine maleate
- CAS No.: 2391-03-9
- Formula:C20H23BrN2O4
- Molecular Weight:435.31
IUPAC Name: (S)-3-(4-bromophenyl)-N,N-dimethyl-3-(pyridin-2-yl)propan-1-amine maleate
InChIKey: SRGKFVAASLQVBO-DASCVMRKSA-N
SMILES: CN(C)CC[C@H](C1=CC=CC=N1)C2=CC=C(C=C2)Br.O=C(O)/C=C\C(O)=O
Biological Activity: Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) maleate is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine maleate exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine maleate with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine maleate alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine maleate can be used in the research of chronic cough and related pathological mechanisms[1][2][3].
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Dexbrompheniramine maleate | Dexbrompheniramine ((+)-Brompheniramine; (S)-Brompheniramine) maleate is a dual inhibitor of histamine H1 receptor and TRPV1 receptor that can cross the blood-brain barrier. Dexbrompheniramine maleate exerts its effects by functionally blocking H1 receptor activity and dose-dependently inhibiting TRPV1-mediated calcium responses, including Capsaicin (HY-10448)-induced responses. The combination of Dexbrompheniramine maleate with Cimetidine (HY-14289) eliminates histamine-induced and sham-feeding-induced drinking behavior, whereas Dexbrompheniramine maleate alone does not induce thirst or alter sham-feeding behavior in rats. Dexbrompheniramine maleate can be used in the research of chronic cough and related pathological mechanisms. | |||||||||||||||||||||
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- [1]. Kraly FS, et al. Histamine and serotonin independently elicit drinking in the rat. Physiol Behav. 1985;34(6):963-967. [Content Brief]
- [2]. Singh U, et al. Investigation of the Pathomechanism of Chronic Cough Using an In Vitro Approach[J]. Clinical and Experimental Allergy, 2025, 55(3): 247.
- [3]. Kraly FS, et al. Preabsorptive pregastric vagally mediated histaminergic component of drinking elicited by eating in the rat. Behav Neurosci. 1984;98(2):349-355. [Content Brief]
Keywords
