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Results for "

antivirulence

" in MedChemExpress (MCE) Product Catalog:

16

Inhibitors & Agonists

1

Peptides

2

Natural
Products

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-N1881
    4',5-Dihydroxyflavone
    3 Publications Verification

    		 Lipoxygenase Glycosidase Inflammation/Immunology
    4',5-Dihydroxyflavone (Compound 2c; Compound B3) is a type of flavonoid compound. 4',5-Dihydroxyflavone can inhibit various oxidases and its IC50 values for collagenase A (ColA) and α-glucosidase are less than 1 μM and 66 μM respectively; for soybean lipoxygenase-1 (LOX-1), its Ki value is 102.6 μM. 4',5-Dihydroxyflavone can be used in studies on anti-toxicity and anti-diabetes .
    4',5-Dihydroxyflavone
  • HY-157322
    SAV13

    		Fluorescent Dye Infection
    SAV13 is an inhibitor of SaeR. SAV13 is an analogue of HR3744. SAV13 inhibits SaeR-DNA probe binding and has antivirulence properties .
    SAV13
  • HY-163542
    Pneumolysin-IN-1

    		Bacterial Inflammation/Immunology
    Pneumolysin-IN-1 (compound PB-3) is a targeted small molecule inhibitor of Pneumolysin (PLY) (IC50=3.1 µM). Pneumolysin-IN-1 is a pore blocking agent and an anti-virulence factor. Pneumolysin-IN-1 can be used to study the infection caused by Streptococcus pneumoniae .
    Pneumolysin-IN-1
  • HY-N0241
    Rhodionin

    		Cholinesterase (ChE) Lipase Bacterial Cytochrome P450 Infection Metabolic Disease
    Rhodionin is an orally active, multifunctional antivirulence and cytoprotective agent that targets and inhibits Lipase, sortase A (SrtA), CYP2D6 (IC50=0.761 μM), AChE (IC50=2.43-57.5 μM), and DPPH free radicals (IC50=19.49 μM). Rhodionin is isolable from the roots of Rhodiola crenulata. Rhodionin reduces postprandial serum triglyceride levels in mice by inhibiting lipase activity. Rhodionin also binds directly to SrtA to inhibit its transpeptidase activity, thereby reducing the fibrinogen adhesion and surface protein A levels of MRSA, effectively inhibiting biofilm formation and protecting against MRSA-induced cell damage. Rhodionin improves the survival rate of infected mice without affecting MRSA growth, and finds wide application in studies related to hyperlipidemia, exogenous obesity, and pneumonia induced by methicillin-resistant Staphylococcus aureus (MRSA) .
    Rhodionin
  • HY-130613
    MAC-545496

    		Bacterial Infection
    MAC-545496 is a nanomolar inhibitor of glycopeptide-resistance-associated protein R (GraR). MAC-545496 displays strong binding affinity to the full-length GraR protein (Kd ≤ 0.1 nM). MAC-545496 is an antivirulence agent that reverses β-lactam resistance in Methicillin-resistant strains (MRSA) .
    MAC-545496
  • HY-176224
    Anti-virulence factor-IN-2

    		Bacterial Infection Inflammation/Immunology
    Anti-virulence factor-IN-2 (compound C7) is an inhibitor targeting the virulence factor KpsM in Escherichia coli. kpsM mediates the translocation of capsular polysaccharides to the cell surface, allowing kpsM-positive E. coli to escape the phagocytosis of the scavenger receptor Marco on liver Kupffer cells, leading to bacterial dissemination. kpsM-positive E. coli exacerbates ethanol-induced liver disease. Anti-virulence factor-IN-2 can inhibit the ethanol-induced liver disease model caused by kpsM-dependent capsid in mice and has anti-infective activity. Anti-virulence factor-IN-2 can be used for the study of alcoholic hepatitis .
    Anti-virulence factor-IN-2
  • HY-162496
    L-NBDNJ

    		Bacterial Infection Inflammation/Immunology
    L-NBDNJ, a glycomimetic, is an antivirulence agent. L-NBDNJ interferes with the expression of proteins regulating cytoskeleton assembly and organization of the host cell. L-NBDNJ has anti-inflammatory and anti-infective effects in models of cystic fibrosis (CF) lung disease infection .
    L-NBDNJ
  • HY-P10200
    CP7-FP13-2

    		Bacterial Infection
    CP7-FP13-2 is a peptide with antivirulence factor and antibacterial activity. CP7-FP13-2 inhibits the formation of Staphylococcus aureus biofilm and has good antibacterial efficacy in mice .
    CP7-FP13-2
  • HY-146327
    PqsR/LasR-IN-1

    		Bacterial Antibiotic Infection
    PqsR/LasR-IN-1 (compound 2a) is a potent PqsR and LasR systems inhibitor. PqsR/LasR-IN-1 has anti-virulence activity against Pseudomonas aeruginosa. PqsR/LasR-IN-1 can reduce production of biofilm, pyocyanin, and rhamnolipids in PA .
    PqsR/LasR-IN-1
  • HY-161124
    SrtA-IN-2

    		Bacterial Infection
    SrtA-IN-2 (compound Y40), a ML346 (HY-18669) analog, is a Sortase A (SrtA) inhibitor. SrtA-IN-2 shows inhibitory activity on Staphylococcus aureus SrtA and shows inhibitory effects on biofilm formation. SrtA-IN-2 is an antivirulence agent against S. aureus infections .
    SrtA-IN-2
  • HY-124469
    UM-C162

    		Bacterial Infection
    UM-C162, a benzimidazole derivative, can rescue nematodes from a S. aureus infection. UM-C162 prevents the formation of biofilm without interfering with bacterial viability. UM-C162 mediates the disruption of S. aureus hemolysins, proteases and clumping factors production. UM-C162 has the potential to be used as an anti-virulence agent to control S. aureus infections .
    UM-C162
  • HY-173598
    T3SS-1-IN-1

    		Bacterial Infection
    T3SS-1-IN-1 (Compound C26) is a T3SS-1 inhibitor. T3SS-1-IN-1 inhibits the secretion of SipA and the activity of HilD (IC50 values are 29.2 and 16.9 μM, respectively). T3SS-1-IN-1 can be used for the study of anti-virulence of Salmonella .
    T3SS-1-IN-1
  • HY-162898
    Anti-virulence factor-IN-1

    		Bacterial Infection
    Anti-virulence factor-IN-1 (Compound 4S) is a bacterial virulence factor inhibitor by interfering with the bacterial infection process. Anti-virulence factor-IN-1 exhibits an antibacterial activity against Xoo in vitro with an EC50 value of 0.28 µg/mL. Anti-virulence factor-IN-1 can be used to effectively manage rice bacterial leaf blight in vivo. Anti-virulence factor-IN-1 is promising for research of plant bacterial disease .
    Anti-virulence factor-IN-1
  • HY-173428
    Antifungal agent 130

    		Fungal Infection
    Antifungal agent 130 (Compound A7) is an orally active antifungal agent. Antifungal agent 130 has good antifungal activity against Candida albicans (MIC = 0.12 ng/mL) and Cryptococcus neoformans (MIC = 0.12 ng/mL) and has excellent antivirulence effect. Antifungal agent 130 exerts its antifungal effect by disrupting the iron homeostasis of fungal cells and inducing oxidative stress damage. Antifungal agent 130 can inhibit the formation of fungal virulence factors (such as biofilm, capsule, urease and melanin). Antifungal agent 130 has good antifungal effect and can be used in the study of drug-resistant fungal infections .
    Antifungal agent 130
  • HY-179376
    Anti-virulence factor-IN-3

    		Bacterial Infection
    Anti-virulence factor-IN-3 (Compound 21) is a covalent β-aminosulfinyl type anthrax edema factor (EF) inhibitor, with a Ki value of 0.44 μM. Anti-virulence factor-IN-3 generates an active ethylene sulfinyl intermediate, which forms an irreversible covalent bond with the Lys residue at the active center of EF, permanently inhibiting the adenylate cyclase activity of EF. Anti-virulence factor-IN-3 effectively inhibits the cAMP production induced by EF, with an EC50 value of 0.15 μM. Anti-virulence factor-IN-3 can be used for research on anthrax Infection .
    Anti-virulence factor-IN-3
  • HY-W904855
    Apicidin D2

    		Endogenous Metabolite Bacterial Infection
    Apicidin D2 (Compound 4), a fungal metabolite, is a Accessory gene regulator A (AgrA) quorum-sensing inhibitor. Apicidin D2 has anti-virulence activity. Apicidin D2 suppresses MRSA agr activation and shows potent inhibitory activities against all agr types in a nonbiocidal manner. Apicidin D2 can be used for MRSA infections research .
    Apicidin D2

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