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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
asparaginase
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "asparaginase" in MCE Product Catalog:
16
Target:
Research Areas:
L-Asparaginase (L-ASNase) is a deamidating enzyme that catalyses the hydrolysis of L-asparagine and L-glutamine, and can be used for the research of acute lymphoblastic leukemia. L-Asparaginase depletes L-asparagine from plasma resulting in inhibition of RNA and DNA synthesis with the subsequent blastic cell apoptosis .
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5 Cited Publications
Cat. No.: HY-W017443
CAS No.: 5794-13-8
1
1 Cited Publications
Cat. No.: HY-N0667S2
CAS No.: 287484-32-6
Synonyms: (-)-Asparagine-15N2 monohydrate; Asn-15N2 monohydrate; Asparamide-15N2 monohydrate
1
1 Cited Publications
Cat. No.: HY-N0667S5
CAS No.: 2483831-59-8
Cat. No.: HY-175282
CAS No.: 2748800-08-8
ASX-173 is an orally active inhibitor of asparagine synthetase (ASNS) (IC50 = 0.113 μM, Ki = 0.4 nM). ASX-173 enhances the anticancer activity of L-asparaginase (ASNase) (HY-P1923). ASX-173 disrupts nucleotide synthesis and induces leukemia cell cycle arrest, apoptosis and autophagy in leukemia cells in combination with ASNase. ASX-173 slows the growth of OCI-AML2 xenografts in combination with ASNase. ASX-173 is indicated for the study of acute lymphoblastic leukemia, acute myeloid leukemia, colorectal cancer, and other cancers .
Synonyms: PEG-L-asparaginase; Pegasparaginase
Target:
Research Areas:
Oncaspar (PEG-L-asparaginase; Pegasparaginase), a pegylated form of native Escherichia coli-derived L-asparaginase, breaks down the amino acid asparagine that are circulating in the bloodstream. Oncaspar plays an important role in acute lymphoblastic leukemia (ALL) through asparagine hydrolysis and activation of the integrated stress response (ISR) pathway .
Cat. No.: HY-W010378
CAS No.: 2058-58-4
Synonyms: H-D-Asn-OH
Target:
Cat. No.: HY-W043748
CAS No.: 38862-24-7
Synonyms: N-Succinimidyl acrylate
Target:
Research Areas:
2,5-Dioxopyrrolidin-1-yl acrylate (N-Succinimidyl acrylate) is a lysine residue modifier and coupling monomer. 2,5-Dioxopyrrolidin-1-yl acrylate covalently modifies the primary amines of lysine residues on monoclonal anti-horseradish peroxidase IgG antibodies, neutralizes positive charges and replaces them with low-affinity acrylate groups. 2,5-Dioxopyrrolidin-1-yl acrylate inhibits the formation of rapid hard coronas on citrate-coated gold nanoparticles, induces antibody unfolding and loss of antigen-binding function, but does not affect the antigen-binding function of antibodies in free solution. 2,5-Dioxopyrrolidin-1-yl acrylate reacts with the ε-amino groups on lysine residues of L-asparaginase, introduces vinyl groups and generates N-hydroxysuccinimide. 2,5-Dioxopyrrolidin-1-yl acrylate regulates the activity of L-asparaginase .
Synonyms: (-)-Asparagine (Standard); Asn (Standard); Asparamide (Standard)
Cat. No.: HY-W017443S
CAS No.: 202406-87-9
Cat. No.: HY-N0667S3
CAS No.: 286460-82-0
Synonyms: (-)-Asparagine-13C4 monohydrate; Asn-13C4 monohydrate; Asparamide-13C4 monohydrate
Cat. No.: HY-W010378R
CAS No.: 2058-58-4
Synonyms: H-D-Asn-OH (Standard)
Research Areas:
D-Asparagine (Standard) (H-D-Asn-OH (Standard)) is the analytical standard of D-Asparagine (HY-W010378). This product is intended for research and analytical applications. D-Asparagine (H-D-Asn-OH) is a competitive inhibitor of L-Asparagine hydrolysis with a Ki value of 0.24 mM. D-Asparagine is a source of nitrogen for yeast strains. D-Asparagine is a good substrate for the external yeast asparaginase but is a poor substrate for the internal enzyme.
Cat. No.: HY-W017443S1
CAS No.: 204451-47-8
Cat. No.: HY-W017443R
CAS No.: 5794-13-8
Category:
Cat. No.: HY-N0667S7
CAS No.: 781596-75-6
Synonyms: (-)-Asparagine-13C4,15N2; Asn-13C4,15N2; Asparamide-13C4,15N2
Cat. No.: HY-N0667S1
CAS No.: 1217473-37-4
Cat. No.: HY-N0667S4
CAS No.: 286437-12-5
Synonyms: (-)-Asparagine-4-13C monohydrate; Asn-4-13C monohydrate; Asparamide-4-13C monohydrate
Cat. No.: HY-N0667S
CAS No.: 1217464-18-0
Cat. No.: HY-W017443S2
CAS No.: 2483829-30-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
