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bioluminescent probes

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Caspase (1) Fluorescent Dye (5) mRNA (1)
By Research Areas:	Cancer (1) Inflammation/Immunology (1)
Oligonucleotides:	mRNA (1) Reporter Genes (1)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-174790

Firefly Luciferase mRNA	mRNA	Cancer
Firefly Luciferase mRNA is a reporter mRNA that can be transfected into cells to express firefly luciferase protein. Firefly Luciferase mRNA induces cytotoxicity in cancer cells at low concentrations. In cancer cells, the expression level of luciferase shows a non-linear relationship with the dose of Firefly Luciferase mRNA. When combined with the H₂S-responsive bioluminescent probe (H-Luc), Firefly Luciferase mRNA enables bioluminescence-based detection of endogenous hydrogen sulfide in non-transgenic NAFLD cell models and NAFLD mouse models. Firefly Luciferase mRNA can be used in studies related to non-alcoholic fatty liver disease .

HY-147507

SBP-1	Fluorescent Dye	Others
SBP-1 is a sulfite bioluminescent probe (SBP). SBP-1 exhibits the excellent responsivity, selectivity and sensitivity towards sulfite. The recognition of SBP-1 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction. SBP-1 can be used for detection of exogenous and endogenous sulfite in living animal. SBP-1 also possesses a capability for quantitatively detecting sulfite within a certain concentration range in solution .

HY-138760

SEluc-2	Fluorescent Dye	Others
SEluc-2 is a small-molecule probe based on the firefly luciferin. SEluc-2, a bioluminescent probe for the sensitive and selective detection of thiols in living cells .

HY-147508

SBP-2	Fluorescent Dye	Others
SBP-2 is a sulfite bioluminescent probe (SBP). The recognition of SBP-2 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction .

HY-147509

SBP-3	Fluorescent Dye	Others
SBP-3 is a sulfite bioluminescent probe (SBP). The recognition of SBP-3 towards sulfite is based on the mechanism of a sulfite-mediated intramolecular cleavage reaction .

HY-D3169

IETDC	Fluorescent Dye Caspase	Inflammation/Immunology
IETDC is a caspase 8 probe substrate. IETDC is cleaved by activated caspase 8 to release D-cysteine. The D-cysteine released by IETDC binds to HCBT to generate firefly luciferin in situ, accompanied by a bioluminescent signal produced by H₂O₂-mediated release of 6-hydroxy-2-cyanobenzothiazole. IETDC is applicable to studies related to acute inflammation .

Cat. No.	Product Name	Type

HY-138760

SEluc-2	Fluorescent Dyes
SEluc-2 is a small-molecule probe based on the firefly luciferin. SEluc-2, a bioluminescent probe for the sensitive and selective detection of thiols in living cells .

HY-D3169

IETDC	Fluorescent Dyes
IETDC is a caspase 8 probe substrate. IETDC is cleaved by activated caspase 8 to release D-cysteine. The D-cysteine released by IETDC binds to HCBT to generate firefly luciferin in situ, accompanied by a bioluminescent signal produced by H₂O₂-mediated release of 6-hydroxy-2-cyanobenzothiazole. IETDC is applicable to studies related to acute inflammation .

Cat. No.	Product Name	Target	Research Area

HY-D3169

IETDC	Fluorescent Dye Caspase	Inflammation/Immunology
IETDC is a caspase 8 probe substrate. IETDC is cleaved by activated caspase 8 to release D-cysteine. The D-cysteine released by IETDC binds to HCBT to generate firefly luciferin in situ, accompanied by a bioluminescent signal produced by H₂O₂-mediated release of 6-hydroxy-2-cyanobenzothiazole. IETDC is applicable to studies related to acute inflammation .

Cat. No.	Product Name		Classification

HY-174790

Firefly Luciferase mRNA		mRNA Reporter Genes
Firefly Luciferase mRNA is a reporter mRNA that can be transfected into cells to express firefly luciferase protein. Firefly Luciferase mRNA induces cytotoxicity in cancer cells at low concentrations. In cancer cells, the expression level of luciferase shows a non-linear relationship with the dose of Firefly Luciferase mRNA. When combined with the H₂S-responsive bioluminescent probe (H-Luc), Firefly Luciferase mRNA enables bioluminescence-based detection of endogenous hydrogen sulfide in non-transgenic NAFLD cell models and NAFLD mouse models. Firefly Luciferase mRNA can be used in studies related to non-alcoholic fatty liver disease .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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