Zn+ Indicator Probes

TSQ is a cytosolic zinc ion fluorescence probe that is membrane permeable and can be used for intracellular imaging of zinc proteins (λ_max ~470 nm). TSQ can combine with Zn²⁺ in the presence of Ca²⁺ and Mg²⁺ to produce blue fluorescence (Ex/Em = 334/495 nm).

Zinquin ethyl ester is a cell-permeable and lipophilic fluorescent derivative of Zinquin (HY-D0982). Zinquin ethyl ester reacts with protein-bound Zn²⁺ in cells and forms fluorescent ternary adducts. Zinquin ethyl ester undergoes hydrolysis by intracellular esterases impeding its efflux across the plasma membrane (Ex/Em = 370/470 nm).

Zinquin is a cell-impermeant fluorescent sensor and used to observe reactive Zn²⁺. λex/λem=368/490 nm.

Zincon sodium is an excellent colorimetric reagent for the detection of zinc and copper ions in aqueous solution. Zincon sodium can be used for the determination of zinc, copper, and cobalt ions in metalloproteins.

Meldola blue is a biosensor for measuring lactate in serum based on screen-printed carbon electrodes modified with Meldola's Blue-Reinecke salt (MBRS-SPCE) coated with lactate dehydrogenase NAD+-dependent enzyme (from pig heart) and NAD+.

Zinquin AM ester is the AM ester form of Zinquin (HY-D0982). Zinquin is a fluorescent dye and a commonly used probe for cellular Zn²⁺ (zinc ion) status.

Probe L is an AIE-based dual-sensing fluorescent probe for the detection of Zn²⁺ and single-stranded DNA (ssDNA). Coordination of Probe L with Zn²⁺ restricts intramolecular rotation and triggers ESIPT, turning on fluorescence at 490 nm. Upon further binding of the Probe L-Zn²⁺ complex to ssDNA, enhanced emission is generated at 550 nm. Ex/Em = 365/490 nm (Zn²⁺); Ex/Em = 365/550 nm (ssDNA).

CR-1 is a ratiometric photoacoustic (PA) probe for in-situ real-time imaging of Zn²⁺ in deep living tissues. CR-1 is formed by coupling the near-infrared cyanine dye IR825 with the Zn²⁺ ligand tris (2-pyridylmethyl) amine (TMPA). Upon binding to Zn²⁺, the five N atoms on TMPA coordinate with Zn²⁺, leading to double bond rearrangement of IR825 and attenuation of its π-electron conjugated system. The absorption peak of CR-1 blue-shifts from 710 nm to 532 nm, enabling quantitative detection of Zn²⁺ via the PA₅₃₂/PA₇₁₀ ratio. Free CR-1 generates a strong PA signal at 710 nm, while CR-1 bound to Zn²⁺ produces a strong PA signal at 532 nm.

ZnAF-1F tetraTFA is a potent fluorophore for with an K_d value of 2.2 nM. ZnAF-1F tetraTFA can be used as fluorescent probes for Zn²⁺ in cells. ZnAF-1F tetraTFA shows λ excitation of 489 nm and λ emission of 514 nm.

ZnAF-1F is a potent fluorophore for with an K_d value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn²⁺ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm.

ZnAF-1, a fluorescein-based zinc sensor containing the N,N-bis(2-pyridylmethyl)ethylenediamine chelating unit, can be used for Zn2+ detection . ZnAF-1 can bind Zn(II) with a 1 : 1 stoichiometry.

Zinquin (solution) is a cell-impermeant fluorescent sensor and used to observe reactive Zn²⁺. λex/λem=368/490 nm.
Solvent and concentration: DMSO: 5 mM

ZP1BG is a SNAP tag fluorescent probe for detecting Zn²⁺, which is formed by the covalent connection of the zinc sensor ZP1 from the Zinpyr family with the benzyl guanine group. ZP1BG can be used to detect the concentration of Zn²⁺ in neuronal organelles such as the Golgi apparatus and mitochondria.

ZnAF-2F DA is a multifunctional dye. Dyes are important tools in biological experiments. They can help researchers observe and analyze cell structures, track biomolecules, evaluate cell functions, distinguish cell types, detect biomolecules, study tissue pathology and monitor microorganisms. Their applications range from basic scientific research to clinical A wide range of diagnostics. Dyes are also widely used in traditional fields such as textile dyeing, as well as in emerging fields such as functional textile processing, food pigments and dye-sensitized solar cells.

PMQA (Zn-green), an 8-aminoquinoline-based ratiometric fluorescent sensor, demonstrates the Zn²⁺-induced redshift of emission (85 nm). PMQA (Zn-green) is a cell membrane-permeable probe and suitable for imaging Zn²⁺ in living cells.