443302-08-7
443302-08-7
Chemical Structure
ZnAF-1F
- CAS No.: 443302-08-7
- Formula:C34H26F2N4O5
- Molecular Weight:608.59
IUPAC Name: 5-((2-(bis(pyridin-2-ylmethyl)amino)ethyl)amino)-2',7'-difluoro-3',6'-dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one
InChIKey: VRUAOMSCYBFMTB-UHFFFAOYSA-N
SMILES: O=C1OC2(C3=C(OC4=C2C=C(F)C(O)=C4)C=C(O)C(F)=C3)C5=C1C=C(NCCN(CC6=NC=CC=C6)CC7=NC=CC=C7)C=C5
Biological Activity: ZnAF-1F is a potent fluorophore for with an Kd value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn2+ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm[1][2][3].
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ZnAF-1F | ZnAF-1F is a potent fluorophore for with an Kd value of 2.2 nM. ZnAF-1F can be used as fluorescent probes for Zn2+ in cells. ZnAF-1F shows λ excitation of 489 nm and λ emission of 514 nm. | |||||||||||||||||||||
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References
- [1]. Hirano T, et al. Improvement and biological applications of fluorescent probes for zinc, ZnAFs. J Am Chem Soc. 2002 Jun 12;124(23):6555-62. [Content Brief]
- [2]. Zhaohua Dai, et al. Tailoring tripodal ligands for zinc sensing. New J. Chem., 2007,31, 1708-1718.
- [3]. Que EL, et al. Metals in neurobiology: probing their chemistry and biology with molecular imaging. Chem Rev. 2008 May;108(5):1517-49. [Content Brief]
Keywords
