7 Results for "

chloroquine-resistant Dd2

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "chloroquine-resistant Dd2" in MCE Product Catalog:

1
123B9
123B9
0 Images
1 Cited Publications
Cat. No.: HY-P10579
CAS No.: 2225868-19-7
Target:  

Ephrin Receptor

Research Areas:  

Cancer

123B9, a tumor-homing agent, is a potent and selective EphA2 agonist with a Kd value of 4.0 μM. 123B9 selectively targets the EphA2 tyrosine kinase receptor ligand-binding domain. 123B9 does not appreciably inhibit the ligand binding domains of the most closely related EphA3 and EphA4 receptors .
loading...
    loading...
View All Sizes
Melicopine
Melicopine
0 Images
Cat. No.: HY-W437569
CAS No.: 568-01-4
Category:  

Alkaloids Cornaceae Cornus officinalis Sieb. et Zucc. Plants Acridone Alkaloids

Target:  

Parasite Insecticide

Melicopine is an alkaloid found in Z. simulans with antimalarial and anticancer activities. It exhibits inhibitory activity against chloroquine-sensitive 3D7 and chloroquine-resistant Dd2 strains of P. falciparum, with IC50 values of 29.7 and 33.7 µg/mL, respectively. Melicopine is cytotoxic to prostate cancer cells PC-3M and LNCaP (IC50 values of 47.9 and 37.8 µg/mL), but has no effect on non-cancerous HEK293 cells (IC50 greater than 100 µg/mL). Melicopine holds promise for research in anticancer and anti-infection fields .
loading...
    loading...
View All Sizes
KAR425
KAR425
0 Images
Cat. No.: HY-116552
CAS No.: 1809050-49-4
Target:  

Parasite

Research Areas:  

Infection

KAR425 is a potent and orally active antimalarial agent. KAR425 shows antimalarial activity against the Chloroquine-sensitive (CQS) D6, the Chloroquine-resistant (CQR) Dd2, and 7G8 strains of Plasmodium falciparum, with IC50 values of 62 nM, 55 nM, and 60 nM, respectively .
loading...
    loading...
View All Sizes
Antimalarial agent 11
Antimalarial agent 11
0 Images
Cat. No.: HY-146769
CAS No.: 1214454-56-4
Target:  

Parasite

Research Areas:  

Infection

Antimalarial agent 11 (compound 1), a spirocyclic chromane, is a potent antimalarial agent. Antimalarial agent 11 exhibits excellent potency with an EC50 of 350 nM against the Chloroquine-resistant Dd2 strain. Antimalarial agent 11 has EC50s of 1.48 µM and 1.81 µM against D6 and ARC08-022 strains, respectively .
loading...
    loading...
View All Sizes
Sterekunthal B
Sterekunthal B
0 Images
Cat. No.: HY-N20619
CAS No.: 475673-78-0
Category:  

Quinones Stereospermum chelonoides DC. Benzene Quinones Plants Bignoniaceae

Target:  

Parasite

Sterekunthal B is a naphthoquinone compound and antimalarial agent. Sterekunthal B can be isolated from plants of the Bignoniaceae family, including the root bark of Stereospermum colais. Sterekunthal B inhibits the growth of Chloroquine (HY-17589A)-sensitive Plasmodium falciparum strain PoW with an IC50 of 23.3 μg/mL. Sterekunthal B also inhibits the growth of Chloroquine-resistant Plasmodium falciparum strain Dd2 with an IC50 of 15.2 μg/mL. Sterekunthal B exhibits non-selective cytotoxicity toward endothelial cells. Sterekunthal B can be used in malaria-related research .
loading...
    loading...
View All Sizes
SB5-171
SB5-171
0 Images
Cat. No.: HY-181544
CAS No.: 3088376-92-2
Target:  

Parasite

Research Areas:  

Infection

SB5-171 is a covalent PfCLK3 inhibitor with IC50 values of 10-12 nM. SB5-171shows antiparasitic activity. SB5-171 can be used for the research of malaria .
loading...
    loading...
View All Sizes
HDAC1-IN-15
HDAC1-IN-15
0 Images
Cat. No.: HY-187346
CAS No.: 3055432-86-2
Target:  

Parasite HDAC

Research Areas:  

Infection

HDAC1-IN-15 is a HDAC1 inhibitor with activity against hHDAC1, PfHDAC1 and HDAC8. HDAC1-IN-15 inhibits the proliferation of asexual blood-stage Plasmodium falciparum and reduces the survival rate of stage IV-V gametocytes of Plasmodium falciparum. HDAC1-IN-15 is applicable to malaria-related research .
loading...
    loading...
View All Sizes
Assay Types