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Cat. No.: HY-187346

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HDAC1-IN-15

HDAC1-IN-15 is a HDAC1 inhibitor with activity against hHDAC1, PfHDAC1 and HDAC8. HDAC1-IN-15 inhibits the proliferation of asexual blood-stage Plasmodium falciparum and reduces the survival rate of stage IV-V gametocytes of Plasmodium falciparum. HDAC1-IN-15 is applicable to malaria-related research.

For research use only. We do not sell to patients.

CAS No.: 3055432-86-2
Formula: C₂₂H₂₂N₆O₅
Molecular Weight:450.45

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC1-IN-15 Chemical Structure

CAS No.: 3055432-86-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

Plasmodium

hHDAC1

hHDAC8

All Parasite Isoforms :

All HDAC Isoforms :

In Vitro

HDAC1-IN-15 (compound 12) (0.005-5 μM; 72 h) potently inhibits proliferation of Plasmodium falciparum 3D7 (IC₅₀ = 0.086 μM) and Chloroquine (HY-17589A)-resistant Dd2 (IC₅₀ = 0.064 μM) asexual blood stages in vitro, with no measurable cytotoxicity against HEK293T cells at concentrations up to 5 μM^[1].
HDAC1-IN-15 (5 μM; 72 h) impairs survival of Plasmodium falciparum NF54 stage IV-V gametocytes, resulting in 47.55% survival^[1].
HDAC1-IN-15 potently inhibits recombinant Plasmodium falciparum PfHDAC1 (96% inhibition at 1 μM, 99% at 10 μM) and human rhHDAC1, rhHDAC8 enzymes in a cell-free enzymatic assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3055432-86-2
Molecular Weight 450.45
Formula C₂₂H₂₂N₆O₅
SMILES

COC1=CC(NC2=C3N=CN(C3=NC=N2)CC4=CC=C(C=C4)C(NO)=O)=CC(OC)=C1OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dias B K M, et al. Repurposing 6-Anilinopurine Derivatives That Exhibit PfHDAC1 Inhibition and Antimalarial Activity against Asexual and Sexual Stages of Plasmodium falciparum. ACS Omega, 2026, 11(28): 41385-41395.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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HDAC1-IN-15

All Parasite Isoforms

All HDAC Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

HDAC1-IN-15 Related Classifications

HY-187346 Related Classifications