HDAC1-IN-15
HDAC1-IN-15 is a HDAC1 inhibitor with activity against hHDAC1, PfHDAC1 and HDAC8. HDAC1-IN-15 inhibits the proliferation of asexual blood-stage Plasmodium falciparum and reduces the survival rate of stage IV-V gametocytes of Plasmodium falciparum. HDAC1-IN-15 is applicable to malaria-related research.
For research use only. We do not sell to patients.
- CAS No.: 3055432-86-2
- Formula: C22H22N6O5
- Molecular Weight:450.45
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Biological Activity
Description
IC50 & Target
[1]|
Plasmodium |
hHDAC1 |
hHDAC8 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HCT-116 | IC50 |
50 μM
Compound: 4h
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Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
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[PMID: 37989057] |
| Jurkat | IC50 |
1.5 μM
Compound: 4h
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Cytotoxicity against human Jurkat cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human Jurkat cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
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[PMID: 37989057] |
| MCF7 | IC50 |
50 μM
Compound: 4h
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Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
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[PMID: 37989057] |
| NAMALVA | IC50 |
0.8 μM
Compound: 4h
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Cytotoxicity against human NAMALVA cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
Cytotoxicity against human NAMALVA cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay
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[PMID: 37989057] |
In Vitro
HDAC1-IN-15 (compound 12) (0.005-5 μM; 72 h) potently inhibits proliferation of Plasmodium falciparum 3D7 (IC50 = 0.086 μM) and Chloroquine (HY-17589A)-resistant Dd2 (IC50 = 0.064 μM) asexual blood stages in vitro, with no measurable cytotoxicity against HEK293T cells at concentrations up to 5 μM[1].
HDAC1-IN-15 (5 μM; 72 h) impairs survival of Plasmodium falciparum NF54 stage IV-V gametocytes, resulting in 47.55% survival[1].
HDAC1-IN-15 potently inhibits recombinant Plasmodium falciparum PfHDAC1 (96% inhibition at 1 μM, 99% at 10 μM) and human rhHDAC1, rhHDAC8 enzymes in a cell-free enzymatic assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3055432-86-2
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Molecular Weight 450.45
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Formula C22H22N6O5
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SMILES
COC1=CC(NC2=C3N=CN(C3=NC=N2)CC4=CC=C(C=C4)C(NO)=O)=CC(OC)=C1OC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC1-IN-15 Related Classifications
HY-187346 Related Classifications
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