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Art. -Nr.: HY-187346

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HDAC1-IN-15

HDAC1-IN-15 is a HDAC1 inhibitor with activity against hHDAC1, PfHDAC1 and HDAC8. HDAC1-IN-15 inhibits the proliferation of asexual blood-stage Plasmodium falciparum and reduces the survival rate of stage IV-V gametocytes of Plasmodium falciparum. HDAC1-IN-15 is applicable to malaria-related research.

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CAS. Nr.: 3055432-86-2
Formel: C₂₂H₂₂N₆O₅
Molecular Weight:450.45

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC1-IN-15 Chemical Structure

CAS. Nr.: 3055432-86-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
Chemical Information
Protokoll (1)
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

Plasmodium

hHDAC1

hHDAC8

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Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	50 μM Compound: 4h	Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay Cytotoxicity against human HCT-116 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay	[PMID: 37989057]
Jurkat	IC₅₀	1.5 μM Compound: 4h	Cytotoxicity against human Jurkat cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay Cytotoxicity against human Jurkat cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay	[PMID: 37989057]
MCF7	IC₅₀	50 μM Compound: 4h	Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay	[PMID: 37989057]
NAMALVA	IC₅₀	0.8 μM Compound: 4h	Cytotoxicity against human NAMALVA cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay Cytotoxicity against human NAMALVA cells assessed as cell growth inhibition incubated for 24 to 72 hrs by MTT assay	[PMID: 37989057]

In Vitro

HDAC1-IN-15 (compound 12) (0.005-5 μM; 72 h) potently inhibits proliferation of Plasmodium falciparum 3D7 (IC₅₀ = 0.086 μM) and Chloroquine (HY-17589A)-resistant Dd2 (IC₅₀ = 0.064 μM) asexual blood stages in vitro, with no measurable cytotoxicity against HEK293T cells at concentrations up to 5 μM^[1].
HDAC1-IN-15 (5 μM; 72 h) impairs survival of Plasmodium falciparum NF54 stage IV-V gametocytes, resulting in 47.55% survival^[1].
HDAC1-IN-15 potently inhibits recombinant Plasmodium falciparum PfHDAC1 (96% inhibition at 1 μM, 99% at 10 μM) and human rhHDAC1, rhHDAC8 enzymes in a cell-free enzymatic assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS. Nr. 3055432-86-2
Molecular Weight 450.45
Formel C₂₂H₂₂N₆O₅
SMILES

COC1=CC(NC2=C3N=CN(C3=NC=N2)CC4=CC=C(C=C4)C(NO)=O)=CC(OC)=C1OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Protokoll

All Cell Biology

Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Dias B K M, et al. Repurposing 6-Anilinopurine Derivatives That Exhibit PfHDAC1 Inhibition and Antimalarial Activity against Asexual and Sexual Stages of Plasmodium falciparum. ACS Omega, 2026, 11(28): 41385-41395.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

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100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Protokoll
Reinheit & Dokumentation
Verweise

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HDAC1-IN-15

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