Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
27 Results for "
common pathway
" in MedChemExpress (MCE) Product Catalog:
Products (27)
27 Results for "common pathway" in MCE Product Catalog:
4
4 Cited Publications
Cat. No.: HY-N0448
CAS No.: 23513-15-7
1
1 Cited Publications
Cat. No.: HY-113206A
CAS No.: 17187-72-3
Target:
Research Areas:
D-Sedoheptulose-7-phosphate barium is a common precursor for the heptoses of septacidin (group III) and hygromycin B (group IV). D-Sedoheptulose-7-phosphate barium can be converted to NDP-heptoses through similar biosynthetic pathways in those compounds .
Cat. No.: HY-W114954
CAS No.: 7382-59-4
Target:
Research Areas:
Guaiacylglycerol-beta-guaiacyl ether is a phenolic β-O-4 type lignin model compound that mimics the most common β-O-4 aryl ether linkages in plant lignin. Guaiacylglycerol-beta-guaiacyl ether can be degraded by Bacillus amyloliquefaciens CotA. Guaiacylglycerol-beta-guaiacyl ether is a commonly used model compound for studying the β-O-4 inter-unit linkage, the most abundant substructure in lignin, and can be applied to investigate the reaction pathway of vanillin preparation via alkaline nitrobenzene oxidation .
Cat. No.: HY-E70544B
CAS No.: 9001-29-0
Research Areas:
Canine Factor X is a vitamin K-dependent plasma serine protease that is activated to generate Factor Xa. Canine Factor X mediates the common coagulation pathway and catalyzes the conversion of prothrombin to thrombin . Canine Factor X is the first enzyme to act in the common pathway of thrombosis in the coagulation cascade. Canine Factor X can be used in studies related to Factor X deficiency .
Category:
Human Gut Microbiota Metabolites Microorganisms Ketones, Aldehydes, Acids Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-P10489
CAS No.: 374675-19-1
Target:
Research Areas:
Cat. No.: HY-172316
CAS No.: 2915316-40-2
Target:
Research Areas:
BAY 3389934 is a selective dual inhibitor of factor IIa and factor Xa, with an IC50 of 4.9 nM for factor IIa and an IC50 of 0.66 nM for factor Xa. BAY 3389934 directly inhibits the activities of factor IIa and factor Xa and regulates the common coagulation pathway. BAY 3389934 exhibits anticoagulant and organ-protective effects. BAY 3389934 can be used in the research of sepsis and coagulopathy .
Cat. No.: HY-E70544A
CAS No.: 9001-29-0
Research Areas:
Bovine Factor X is a vitamin K-dependent plasma serine protease that is activated to generate Factor Xa. Bovine Factor X mediates the common coagulation pathway and catalyzes the conversion of prothrombin to thrombin . Bovine Factor X is the first enzyme to act in the common pathway of thrombosis in the coagulation cascade. Bovine Factor X can be used in studies related to Factor X deficiency .
Cat. No.: HY-141467S
CAS No.: 607721-34-6
Cat. No.: HY-N7241
CAS No.: 94978-16-2
Target:
Cat. No.: HY-E70690
CDK8 modulates the transcriptional output from distinct transcription factors involved in oncogenic control, including the Wnt/β-catenin pathway, Notch, p53, and transforming growth factor β. Abnormal activity ofCDK8 along with its partner protein cyclin C (CycC) is a common feature of many diseases including colorectal cancer. CDK8/CycC Recombinant Human Active Protein Kinase can be used to study the function of CDK8/CycC .
Cat. No.: HY-E70544C
CAS No.: 9001-29-0
Research Areas:
Rabbit Factor X is a vitamin K-dependent plasma serine protease that is activated to generate Factor Xa. Rabbit Factor X mediates the common coagulation pathway and catalyzes the conversion of prothrombin to thrombin . Rabbit Factor X is the first enzyme to act in the common pathway of thrombosis in the coagulation cascade. Rabbit Factor X can be used in studies related to Factor X deficiency .
Cat. No.: HY-E71124
Target:
Research Areas:
(S)-Mandelate dehydrogenase (EC 1.1.99.31) belongs to the FMN-dependent α-hydroxy acid oxidase/dehydrogenase family. (S)-Mandelate dehydrogenase (EC 1.1.99.31) is part of a Pseudomonas metabolic pathway that enables these organisms to utilize mandelic acid (derived from the common soil metabolite amygdalin) as their sole carbon and energy source.
Cat. No.: HY-141467S1
Cat. No.: HY-L101
3,003 compounds
Liver cancer is one of the leading malignancies which occupies the second position in cancer deaths worldwide, becoming serious threat to human health. Hepatocellular carcinoma (HCC), also known as hepatoma is the most common type accounting for approximately 90% of all liver cancers.
Current evidence indicates that during hepatocarcinogenesis, two main pathogenic mechanisms prevail: (1) cirrhosis associated with hepatic regeneration after tissue damage caused by hepatitis infection, toxins or metabolic influences, and (2) mutations occurring in single or multiple oncogenes or tumor suppressor genes. Both mechanisms have been linked with alterations in several important cellular signaling pathways. These include the RAF/MEK/ERK pathway, PI3K/AKT/mTOR pathway, WNT/b-catenin pathway, insulin-like growth factor pathway, c-MET/HGFR pathway , etc.
MCE offers a unique collection of 3,003 compounds with identified and potential anti-liver cancer activity. MCE anti-liver cancer compound library is a useful tool for anti-liver cancer drugs screening and other related research.
Cat. No.: HY-L125
2,810 compounds
Pulmonary fibrosis (PF), also known as diffuse interstitial pulmonary fibrosis, is a very common end-stage manifestation of several diseases, including idiopathic pulmonary fibrosis (IPF), pulmonary hypertension, and scleroderma, characterised by excessive matrix deposition and destruction of the lung architecture, finally leading to respiratory insufficiency. PF has become a global disease with significantly increased incidence rate, and the most common form of pulmonary fibrosis is idiopathic pulmonary fibrosis (IPF).
Lung fibrosis is a complex disease, a multitude of signal factors and signaling pathways is disrupted in this complex disease, such as TGF-β, Wnt, VEGF and PI3K–Akt. MCE offers a unique collection of 2,810 compounds with identified and potential anti-pulmonary fibrosis activity. MCE Anti-Pulmonary Fibrosis Compound Library is a useful tool for anti-pulmonary fibrosis drugs screening and other related research.
Cat. No.: HY-180120
Target:
Research Areas:
UM-203 is a reversible covalent STING antagonist. UM-203 is effective against both mouse and human STING, and in particular, it inhibits the most common human STING R232 variant. UM-203 can inhibit STING oligomerization and reduce phosphorylation of downstream TBK1 and IRF3, thereby blocking the IRF3 and NF-κB-mediated signaling pathways and inhibiting IFNβ and IL-6 secretion. UM-203 can be used for the research of inflammation and immunology, such as systemic lupus erythematosus .
Cat. No.: HY-189222
CAS No.: 3118096-98-0
Target:
Research Areas:
RP04340 is an orally active, selective pan-KRAS PROTAC degrader. RP04340 hijacks the CRBN E3 ligase and the cellular proteasome system to degrade KRAS, without degrading HRAS, NRAS, or common CRBN neosubstrates. RP04340 inhibits KRAS downstream signaling pathways, including pERK and DUSP6. RP04340 exhibits anticancer activity in various KRAS-mutant cancers. RP04340 can be used to study kras-driven cancers, including pancreatic ductal adenocarcinoma, colorectal cancer, and lung adenocarcinoma .
Cat. No.: HY-L103
2,653 compounds
Colorectal cancer (CRC), also known as bowel cancer, colon cancer, or rectal cancer, arises as adenocarcinoma from glandular epithelial cells of the large intestine comprised of the colon and rectum. The majority of cases of CRC are sporadic and result from risk factors, such as a sedentary lifestyle, obesity, processed diets, alcohol consumption and smoking. CRC is also a common preventable cancer.
Studies showed several cellular signaling pathways dysregulated in CRC, leading to the onset of malignant phenotypes. Therefore, it is necessary to analyze the signaling pathways involved in the occurrence and development of colorectal cancer to study the progression and drug treatment of colorectal cancer. Among them, Wnt/β-catenin, p53, TGF-β/SMAD, NF-κB, Notch, VEGF and other target genes and signaling pathways are the focus of research. MCE offers a unique collection of 2,653 compounds with identified and potential anti-colorectal cancer activity. MCE anti-colorectal cancer compound library is a useful tool for anti-colorectal cancer drugs screening and other related research.
Cat. No.: HY-L196
4,585 compounds
Protein Kinases (PTKs) are a class of phosphotransferases that phosphorylate proteins. Protein kinases participate in many signal transduction pathways including those involved with growth, differentiation, and cell division. Protein kinase not only plays an important role in the process of cell activation, but also its abnormal expression is closely related to the pathogenesis of many diseases. So far, the protein kinase family has become one of the most important drug targets. The most common drug targets include ALK, B-Raf, BCR-Abl, EGFR, and VEGFR.
MCE designs a unique collection of 4,585 bioactive compounds targeting protein kinases, which is an important tool for the development of drug targeting protein kinases.
- 1
- 2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
