2. Metabolic Enzyme/Protease
  3. Factor Xa
  4. BAY 3389934

BAY 3389934 is a selective dual inhibitor of factor IIa and factor Xa, with an IC50 of 4.9 nM for factor IIa and an IC50 of 0.66 nM for factor Xa. BAY 3389934 directly inhibits the activities of factor IIa and factor Xa and regulates the common coagulation pathway. BAY 3389934 exhibits anticoagulant and organ-protective effects. BAY 3389934 can be used in the research of sepsis and coagulopathy.

For research use only. We do not sell to patients.

BAY 3389934

BAY 3389934 Chemical Structure

CAS No. : 2915316-40-2

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Based on 1 publication(s) in Google Scholar

BAY 3389934 Related Antibodies

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Description

BAY 3389934 is a selective dual inhibitor of factor IIa and factor Xa, with an IC50 of 4.9 nM for factor IIa and an IC50 of 0.66 nM for factor Xa. BAY 3389934 directly inhibits the activities of factor IIa and factor Xa and regulates the common coagulation pathway. BAY 3389934 exhibits anticoagulant and organ-protective effects. BAY 3389934 can be used in the research of sepsis and coagulopathy[1].

In Vitro

BAY 3389934 (1 mg/L; 5 h) metabolizes rapidly in rat plasma, shows moderate stability in rabbit, miniature pig and dog plasma, and exhibits the highest stability in human plasma[1].
BAY 3389934 exhibits high hepatic clearance in rats, moderate clearance in dogs, and low clearance in human hepatocytes, and shows moderate plasma protein binding across different species[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

BAY 3389934 Related Antibodies
In Vivo

BAY 3389934 (0.1-3 mg/kg/h; intravenous infusion; 0-3 h) exhibits dose-dependent antithrombotic efficacy in female New Zealand white rabbits, female Göttingen minipigs and baboons, and significantly alleviates hypercoagulability and protects organs from damage in a Staphylococcus aureus sepsis model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: New Zealand White rabbit (Female)[1]
Dosage: 0.1, 0.3, 1, 3 mg/kg/h
Administration: i.v.; continuous infusion
Result: Produced significant, dose-dependent antithrombotic efficacy starting at 0.1 mg/kg/h, as measured by reduced thrombus weight.
Resulted in shorter ear bleeding times than unfractionated heparin at doses with comparable antithrombotic effects.
Clinical Trial
Molecular Weight

624.13

Formula

C26H30ClN5O7S2
CAS No.
SMILES

CN1C=CN=C1CCOC([C@@H](NS(C2=C(CC)C(N3C([C@@H](O)CC3)=O)=CC=C2)(=O)=O)CNC(C4=CC=C(Cl)S4)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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BAY 3389934 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BAY 33899342915316-40-2BAY3389934BAY-3389934Factor XaFxaplateletsfibrinogenbaboonhuman plasmasepsiscommon coagulation pathwaysepsis-associated coagulopathydisseminated intravascular coagulationfactor IIafactor XaInhibitorinhibitorinhibit

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