Search Result
Results for "
crosslinking reagent
" in MedChemExpress (MCE) Product Catalog:
39
Biochemical Assay Reagents
1
Isotope-Labeled Compounds
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
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- HY-17389
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(+)-Genipin
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Autophagy
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Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
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Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research .
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- HY-78961
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EMCS
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ADC Linker
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Cancer
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6-Maleimidohexanoic acid N-hydroxysuccinimide ester (EMCS) is a heterobifunctional cross-linking reagent. EMCS is used as a unique and useful reagent for preparation of hapten conjugate and enzyme immunoconjugates .
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- HY-W035129
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Biochemical Assay Reagents
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Others
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endo-BCN-NHS carbonate is an elastin-like protein (ELP) modification reagent. endo-BCN-NHS carbonate can react with lysine residues in ELP to make ELP carry BCN groups, and then cross-link ELP through strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. endo-BCN-NHS carbonate promotes hydrogel formation. endo-BCN-NHS carbonate is mainly used in cell encapsulation related research .
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- HY-101794
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(S)-2-Pyridylthio Cysteamine Hydrochloride
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Biochemical Assay Reagents
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Others
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2-(Pyridyldithio)ethylamine hydrochloride is a novel disulfide intercalating cross-linking reagent.
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- HY-130086
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ADC Linker
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Cancer
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Bis-PEG4-NHS ester is a crosslinking reagent and amine-reactive modulator .Bis-PEG4-NHS ester reacts with primary amine groups on liposome surfaces via amide bond formation to covalently attach dibenzylcyclooctyne groups, with a hydrophilic PEG4 spacer reducing steric hindrance for subsequent click chemistry .Bis-PEG4-NHS ester enables site-specific antibody coupling to liposome surfaces via copper-free strain-promoted alkyne-azide cycloaddition click chemistry without disrupting liposome structure in minimal organic solvent volumes .Bis-PEG4-NHS ester undergoes hydrolysis during annealing to form -COOH groups that interact with PbI and FAI to enhance perovskite structural integrity, passivate defects, and modulate nucleation kinetics to regulate crystal growth .Bis-PEG4-NHS ester enhances device efficiency and long-term stability when used as an antisolvent additive for p-i-n perovskite solar cells .
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- HY-76222
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Drug Intermediate
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Others
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Isatoic anhydride is a single-adduct forming reagent and a monofunctional SHAPE reagent. Isatoic anhydride reacts with the 2'-hydroxyl group of RNA nucleotides via a single reactive group to form a single adduct, without forming cross-links between nucleotides. In SHAPE-JuMP experiments, Isatoic anhydride serves as a control reagent for single-adduct formation, which is used to distinguish true cross-links from single-adduct formation .
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- HY-145149
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ADC Payload
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Cancer
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Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].
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- HY-W190796A
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PROTAC Linkers
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Others
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Mal-PEG3-NH2 TFA is a linear heterobifunctional PEG reagent with a maleimide and an amine. Mal-PEG3-NH2 TFA is a crosslinking reagent with a PEG spacer .
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- HY-W016618
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Ethyl benzoylformate; Phenylglyoxylic acid ethyl ester
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Drug Intermediate
Biochemical Assay Reagents
Carboxylesterase (CES)
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Others
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Ethyl phenylglyoxylate (Ethyl benzoylformate), the ethyl ester of phenylglyoxylic acid, is used as a synthetic reagent. Ethyl phenylglyoxylate is also a poor substrate but a potent inhibitor of chicken liver carboxylesterase. Additionally, Ethyl phenylglyoxylate exhibits photoreactivity, where its excited triplet carbonyl can initiate intermolecular hydrogen abstraction, radical coupling and cross-linking reactions .
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- HY-114354
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BOD FL alkyne
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Fluorescent Dye
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Inflammation/Immunology
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BODIPY (BOD) FL alkyne is an alkyne-containing BODIPY fluorophore derivative. BODIPY FL alkyne is a bioorthogonal labeling reagent with low toxicity and extremely low non-specific reactivity, and it is widely used in fluorescent bioimaging. BODIPY FL alkyne specifically labels azide groups on intracellular glycoconjugates mainly via strain-promoted azide-alkyne cycloaddition (SPAAC), or mediates site-specific conjugation with proteins such as IL-33, and supports positive cross-linking with other probes (e.g., DBCO-SCy5) for dual labeling. With the advantages of high specificity and low background interference, BODIPY FL alkyne can be used in the research of related diseases such as asthma, atopic dermatitis and inflammatory bowel disease .
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- HY-W190796
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PROTAC Linkers
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Others
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Mal-PEG3-NH2 is a linear heterobifunctional PEG reagent with a maleimide and an amine. Mal-PEG3-NH2 is a crosslinking reagent with a PEG spacer .
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- HY-W012166
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NHS-Bromoacetate
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Biochemical Assay Reagents
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Infection
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N-Succinimidyl bromoacetate (NHS-Bromoacetate) is a heterobifunctional crosslinking reagent, mainly used to modify the ɛ-amino group of lysine side chains. By covalently linking its bromoacetyl moiety to the ɛ-amino group of lysine in peptidomimetics, N-Succinimidyl bromoacetate enables their conjugation with thiol-modified nanoparticles via thioether bonds. N-Succinimidyl bromoacetate also performs bromoacetylation modification on carrier proteins, which then forms stable thioether bonds with the thiol groups of cysteine in peptides, thus efficiently preparing soluble peptide-protein conjugates with high substitution ratios. N-Succinimidyl bromoacetate can be used to prepare activated Sepharose derivatives for affinity chromatography, protein affinity labeling reagents, and peptide-protein immunogen conjugates with non-immunogenic linkages. N-Succinimidyl bromoacetate is applicable to studies related to HIV-1 infection and glioblastoma multiforme .
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- HY-120937
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Biochemical Assay Reagents
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Others
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DC4 Crosslinker is a stable crosslinking reagent with improved activity and solubility. DC4 Crosslinker is labile cleavable with collision-induced dissociation (CID), that will be fragmented into four rearrange products containing mobilized protons .
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- HY-W000887
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Biochemical Assay Reagents
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Others
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4-Carboxyphenylboronic acid pinacol ester can be used as a starting material for N-(2-acryloylamino-ethyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (AEBB). 4-Carboxyphenylboronic acid pinacol ester can be used to crosslink epoxidized natural rubber (ENR) to silica. 4-Carboxyphenylboronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
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- HY-17389R
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(+)-Genipin (Standard)
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Reference Standards
Autophagy
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Neurological Disease
Metabolic Disease
Inflammation/Immunology
Cancer
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Genipin (Standard) is the analytical standard of Genipin. This product is intended for research and analytical applications. Genipin ((+)-Genipin) is a natural crosslinking reagent derived from Gardenia jasminoides Ellis fruits. Genipin inhibits UCP2 (uncoupling protein 2) in cells. Genipin has a variety of bioactivities, including modulation on proteins, antitumor, anti-inflammation, immunosuppression, antithrombosis, and protection of hippocampal neurons. Genipin also can be used for type 2 diabetes research .
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- HY-W190766
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S-Acetyl-dPEG(R)8-NHS ester
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Biochemical Assay Reagents
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dPEG(R)8-SATA (S-Acetyl-dPEG(R)8-NHS ester) is a bioconjugation reagent with excellent biocompatibility and high selectivity. dPEG(R)8-SATA can be used to label and cross-link biomolecules and promote the interaction between biomolecules. dPEG(R)8-SATA plays an important role in bioimaging and compound delivery systems.
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- HY-W051391
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Me3TACN
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Biochemical Assay Reagents
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Others
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1,4,7-Trimethyl-1,4,7-triazonane, also known as TMT or trimethylenetris(aziridine), is a cyclic organic compound. TMT is commonly used as a crosslinking agent and a precursor for polymer and resin synthesis. In addition, it is used as a stabilizer in the production of polyurethane foam and as a curing agent for epoxy resins. Due to its high reactivity and stability, TMT is considered to be a versatile and efficient reagent in various applications.
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- HY-129655
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ADC Linker
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Cancer
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Sulfo-SMPB sodium is a non-cleavable, heterobifunctional chemical cross-linking reagent which contains N-hydroxysuccinimide (NHS) ester and maleimide groups, allowing covalent conjugation of amine- and sulfhydryl-containing molecules .
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- HY-W127344
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Biochemical Assay Reagents
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Others
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Oleoyl chloride A pungent-smelling liquid commonly used as a reagent in organic synthesis, especially for the production of a variety of organic compounds, including pharmaceuticals and agrochemicals. In addition, it can also be used as a cross-linking agent or surfactant in polymer chemistry. Its unique chemical properties make it an important ingredient in a variety of industrial processes, including petrochemical refining and materials science.
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- HY-W1048545H
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Amine-PEG1000-Thiol hydrochloride
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Biochemical Assay Reagents
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Others
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H2N-PEG1000-SH (Amine-PEG1000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG1000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-128952G
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SG3249
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Drug-Linker Conjugates for ADC
DNA Alkylator/Crosslinker
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Cancer
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Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
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- HY-151738
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ADC Linker
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Others
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Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-W105731
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Decamethylene diiodide
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Endogenous Metabolite
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Others
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1,10-Diiododecane (Decamethylene diiodide) serves as a crosslinking reagent for tetrabutylammonium polygalacturonic acid and acts as an alkylating agent in the synthesis of both symmetrical and unsymmetrical bis-cryptophanes, in addition to being utilized for the production of decane at a temperature of 20°C.
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- HY-174964
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Biochemical Assay Reagents
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Others
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8-Arm-PEG400-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174957A
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Biochemical Assay Reagents
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Others
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6-Arm-PEG600-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-W1123922D
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Biochemical Assay Reagents
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Others
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4-Arm-PEG3400-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG3400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174957C
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Biochemical Assay Reagents
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Others
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6-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-W1048545D
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Amine-PEG10000-Thiol hydrochloride
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Biochemical Assay Reagents
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Others
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H2N-PEG10000-SH (Amine-PEG10000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG10000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W016618R
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Ethyl benzoylformate (Standard); Phenylglyoxylic acid ethyl ester (Standard)
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Drug Intermediate
Reference Standards
Biochemical Assay Reagents
Carboxylesterase (CES)
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Others
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Ethyl phenylglyoxylate (Ethyl benzoylformate) (Standard) is the analytical standard of Ethyl phenylglyoxylate (HY-W016618). This product is intended for research and analytical applications. Ethyl phenylglyoxylate (Ethyl benzoylformate), the ethyl ester of phenylglyoxylic acid, is used as a synthetic reagent. Ethyl phenylglyoxylate is also a poor substrate but a potent inhibitor of chicken liver carboxylesterase. Additionally, Ethyl phenylglyoxylate exhibits photoreactivity, where its excited triplet carbonyl can initiate intermolecular hydrogen abstraction, radical coupling and cross-linking reactions .
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- HY-W1048545A
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Amine-PEG2000-Thiol hydrochloride
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Biochemical Assay Reagents
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Others
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H2N-PEG2000-SH (Amine-PEG2000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG2000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W127719
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Biochemical Assay Reagents
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Others
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Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- HY-W701476
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Ethyl benzoylformate-d5; Phenylglyoxylic acid ethyl ester-d5
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Isotope-Labeled Compounds
Biochemical Assay Reagents
Drug Intermediate
Carboxylesterase (CES)
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Others
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Ethyl phenylglyoxylate-d5 (Ethyl benzoylformate-d5; Phenylglyoxylic acid ethyl ester-d5) is the deuterium labeled Ethyl phenylglyoxylate (HY-W016618). Ethyl phenylglyoxylate (Ethyl benzoylformate), the ethyl ester of phenylglyoxylic acid, is used as a synthetic reagent. Ethyl phenylglyoxylate is also a poor substrate but a potent inhibitor of chicken liver carboxylesterase. Additionally, Ethyl phenylglyoxylate exhibits photoreactivity, where its excited triplet carbonyl can initiate intermolecular hydrogen abstraction, radical coupling and cross-linking reactions .
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- HY-182668
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Biochemical Assay Reagents
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Others
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EDTA Antigen Retrieval Solution, 50× is a commonly used antigen retrieval solution that can effectively remove cross-links between proteins caused by aldehyde fixation reagents, fully exposing antigenic epitopes in samples such as paraffin sections. It can be used for antigen retrieval in samples such as paraffin sections and frozen sections after fixation with paraformaldehyde, formaldehyde, or other aldehyde reagents.
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- HY-W1123922H
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Biochemical Assay Reagents
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Others
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4-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174964H
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Biochemical Assay Reagents
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Others
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8-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174964E
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Biochemical Assay Reagents
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Others
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8-Arm-PEG5000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG5000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174964C
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Biochemical Assay Reagents
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Others
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8-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-W1123922A
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Biochemical Assay Reagents
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Others
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4-Arm-PEG600-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174957
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Biochemical Assay Reagents
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Others
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6-Arm-PEG400-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174964A
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Biochemical Assay Reagents
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Others
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8-Arm-PEG600-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174957H
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Biochemical Assay Reagents
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Others
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6-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-W1123922C
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Biochemical Assay Reagents
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Others
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4-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174957B
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Biochemical Assay Reagents
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Others
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6-Arm-PEG1000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG1000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-101794R
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(S)-2-Pyridylthio Cysteamine Hydrochloride (Standard)
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Biochemical Assay Reagents
Reference Standards
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Others
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2-(Pyridyldithio)ethylamine hydrochloride (Standard) ((S)-2-Pyridylthio Cysteamine Hydrochloride (Standard)) is the analytical standard of 2-(Pyridyldithio)ethylamine hydrochloride (HY-101794). This product is intended for research and analytical applications. 2-(Pyridyldithio)ethylamine hydrochloride is a novel disulfide intercalating cross-linking reagent.
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- HY-174964D
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Biochemical Assay Reagents
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Others
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8-Arm-PEG3400-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG3400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-W1123922E
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Biochemical Assay Reagents
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Others
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4-Arm-PEG5000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG5000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-W1123922B
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Biochemical Assay Reagents
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Others
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4-Arm-PEG1000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG1000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174957E
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Biochemical Assay Reagents
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Others
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6-Arm-PEG5000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG5000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174964B
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Biochemical Assay Reagents
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Others
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8-Arm-PEG1000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG1000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-W1123922
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Biochemical Assay Reagents
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Others
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4-Arm-PEG400-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-174957D
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Biochemical Assay Reagents
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Others
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6-Arm-PEG3400-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG3400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
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- HY-182698
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Biochemical Assay Reagents
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Others
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Tris Antigen Retrieval Solution, 10×, pH 9.0, is composed of Tris, trace amounts of Tween20, etc. It can effectively remove cross-links between proteins caused by aldehyde fixation reagents, fully expose antigenic epitopes in paraffin sections and other samples, and can be used for antigen retrieval after paraffin sections, frozen sections and other samples are fixed with paraformaldehyde, formaldehyde or other aldehyde reagents.
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- HY-W414754
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Biochemical Assay Reagents
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Others
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2,5-Dioxopyrrolidin-1-yl methyl phthalate is a cross-linking agent used for modification of proteins and peptides. 2,5-Dioxopyrrolidin-1-yl methyl phthalate is a reagent for introducing succinimide-activated esters that react with primary amines in proteins and peptides to form stable amide bonds.
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- HY-W1048545I
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Amine-PEG3400-Thiol hydrochloride
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Biochemical Assay Reagents
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Others
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H2N-PEG3400-SH (Amine-PEG3400-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG3400-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W1048545E
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Amine-PEG20000-Thiol hydrochloride
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Biochemical Assay Reagents
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Others
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H2N-PEG20000-SH (Amine-PEG20000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG20000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W1048545J
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Amine-PEG40000-Thiol hydrochloride
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Biochemical Assay Reagents
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Others
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H2N-PEG40000-SH (Amine-PEG40000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG40000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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- HY-W1048545C
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Amine-PEG5000-Thiol hydrochloride
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Biochemical Assay Reagents
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Others
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H2N-PEG5000-SH (Amine-PEG5000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG5000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
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-
| Cat. No. |
Product Name |
Type |
-
- HY-114354
-
|
BOD FL alkyne
|
Fluorescent Dyes
|
|
BODIPY (BOD) FL alkyne is an alkyne-containing BODIPY fluorophore derivative. BODIPY FL alkyne is a bioorthogonal labeling reagent with low toxicity and extremely low non-specific reactivity, and it is widely used in fluorescent bioimaging. BODIPY FL alkyne specifically labels azide groups on intracellular glycoconjugates mainly via strain-promoted azide-alkyne cycloaddition (SPAAC), or mediates site-specific conjugation with proteins such as IL-33, and supports positive cross-linking with other probes (e.g., DBCO-SCy5) for dual labeling. With the advantages of high specificity and low background interference, BODIPY FL alkyne can be used in the research of related diseases such as asthma, atopic dermatitis and inflammatory bowel disease .
|
-
- HY-128952G
-
|
SG3249
|
Fluorescent Dyes
|
|
Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
|
| Cat. No. |
Product Name |
Type |
-
- HY-101794
-
|
(S)-2-Pyridylthio Cysteamine Hydrochloride
|
Biochemical Assay Reagents
|
|
2-(Pyridyldithio)ethylamine hydrochloride is a novel disulfide intercalating cross-linking reagent.
|
-
- HY-77961
-
|
N-ε-Maleimidocaproic acid hydrazide TFA
|
Biochemical Assay Reagents
|
|
6-Maleimidocaproic acid hydrazide TFA is a carbonyl and sulfhydryl reactive heterobifunctional crosslinking reagent .
|
-
- HY-W000887
-
|
|
Biochemical Assay Reagents
|
|
4-Carboxyphenylboronic acid pinacol ester can be used as a starting material for N-(2-acryloylamino-ethyl)-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzamide (AEBB). 4-Carboxyphenylboronic acid pinacol ester can be used to crosslink epoxidized natural rubber (ENR) to silica. 4-Carboxyphenylboronic acid pinacol ester is a biochemical reagent that can be used as a biological material or organic compound for life science related research .
|
-
- HY-W051391
-
|
Me3TACN
|
Biochemical Assay Reagents
|
|
1,4,7-Trimethyl-1,4,7-triazonane, also known as TMT or trimethylenetris(aziridine), is a cyclic organic compound. TMT is commonly used as a crosslinking agent and a precursor for polymer and resin synthesis. In addition, it is used as a stabilizer in the production of polyurethane foam and as a curing agent for epoxy resins. Due to its high reactivity and stability, TMT is considered to be a versatile and efficient reagent in various applications.
|
-
- HY-W127344
-
|
|
Biochemical Assay Reagents
|
|
Oleoyl chloride A pungent-smelling liquid commonly used as a reagent in organic synthesis, especially for the production of a variety of organic compounds, including pharmaceuticals and agrochemicals. In addition, it can also be used as a cross-linking agent or surfactant in polymer chemistry. Its unique chemical properties make it an important ingredient in a variety of industrial processes, including petrochemical refining and materials science.
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-
- HY-W1048545H
-
|
Amine-PEG1000-Thiol hydrochloride
|
Biochemical Assay Reagents
|
|
H2N-PEG1000-SH (Amine-PEG1000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG1000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-128952G
-
|
SG3249
|
Biochemical Assay Reagents
|
|
Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
|
-
- HY-174964
-
|
|
Biochemical Assay Reagents
|
|
8-Arm-PEG400-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174957A
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG600-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-W1123922D
-
|
|
Biochemical Assay Reagents
|
|
4-Arm-PEG3400-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG3400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174957C
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-W1048545D
-
|
Amine-PEG10000-Thiol hydrochloride
|
Biochemical Assay Reagents
|
|
H2N-PEG10000-SH (Amine-PEG10000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG10000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-W1048545A
-
|
Amine-PEG2000-Thiol hydrochloride
|
Biochemical Assay Reagents
|
|
H2N-PEG2000-SH (Amine-PEG2000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG2000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-W127719
-
|
|
Biochemical Assay Reagents
|
|
Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-182668
-
|
|
Biochemical Assay Reagents
|
|
EDTA Antigen Retrieval Solution, 50× is a commonly used antigen retrieval solution that can effectively remove cross-links between proteins caused by aldehyde fixation reagents, fully exposing antigenic epitopes in samples such as paraffin sections. It can be used for antigen retrieval in samples such as paraffin sections and frozen sections after fixation with paraformaldehyde, formaldehyde, or other aldehyde reagents.
|
-
- HY-W1123922H
-
|
|
Biochemical Assay Reagents
|
|
4-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174964H
-
|
|
Biochemical Assay Reagents
|
|
8-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174964E
-
|
|
Biochemical Assay Reagents
|
|
8-Arm-PEG5000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG5000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174964C
-
|
|
Biochemical Assay Reagents
|
|
8-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-W1123922A
-
|
|
Biochemical Assay Reagents
|
|
4-Arm-PEG600-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174957
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG400-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174964A
-
|
|
Biochemical Assay Reagents
|
|
8-Arm-PEG600-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG600-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174957H
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG10000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG10000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-W1123922C
-
|
|
Biochemical Assay Reagents
|
|
4-Arm-PEG2000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG2000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174957B
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG1000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG1000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-101794R
-
|
(S)-2-Pyridylthio Cysteamine Hydrochloride (Standard)
|
Biochemical Assay Reagents
|
|
2-(Pyridyldithio)ethylamine hydrochloride (Standard) ((S)-2-Pyridylthio Cysteamine Hydrochloride (Standard)) is the analytical standard of 2-(Pyridyldithio)ethylamine hydrochloride (HY-101794). This product is intended for research and analytical applications. 2-(Pyridyldithio)ethylamine hydrochloride is a novel disulfide intercalating cross-linking reagent.
|
-
- HY-174964D
-
|
|
Biochemical Assay Reagents
|
|
8-Arm-PEG3400-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG3400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-W1123922E
-
|
|
Biochemical Assay Reagents
|
|
4-Arm-PEG5000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG5000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-W1123922B
-
|
|
Biochemical Assay Reagents
|
|
4-Arm-PEG1000-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG1000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174957E
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG5000-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG5000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174964B
-
|
|
Biochemical Assay Reagents
|
|
8-Arm-PEG1000-DSPE is a PEG cross-linking reagent that links eight PEG branches to one DSPE phospholipid. 8-Arm-PEG1000-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-W1123922
-
|
|
Biochemical Assay Reagents
|
|
4-Arm-PEG400-DSPE is a PEG cross-linking reagent that links four PEG branches to one DSPE phospholipid. 4-Arm-PEG400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-174957D
-
|
|
Biochemical Assay Reagents
|
|
6-Arm-PEG3400-DSPE is a PEG cross-linking reagent that links six PEG branches to one DSPE phospholipid. 6-Arm-PEG3400-DSPE can be used for drug delivery, gene transfection, and vaccine delivery .
|
-
- HY-182698
-
|
|
Biochemical Assay Reagents
|
|
Tris Antigen Retrieval Solution, 10×, pH 9.0, is composed of Tris, trace amounts of Tween20, etc. It can effectively remove cross-links between proteins caused by aldehyde fixation reagents, fully expose antigenic epitopes in paraffin sections and other samples, and can be used for antigen retrieval after paraffin sections, frozen sections and other samples are fixed with paraformaldehyde, formaldehyde or other aldehyde reagents.
|
-
- HY-W414754
-
|
|
Biochemical Assay Reagents
|
|
2,5-Dioxopyrrolidin-1-yl methyl phthalate is a cross-linking agent used for modification of proteins and peptides. 2,5-Dioxopyrrolidin-1-yl methyl phthalate is a reagent for introducing succinimide-activated esters that react with primary amines in proteins and peptides to form stable amide bonds.
|
-
- HY-W1048545I
-
|
Amine-PEG3400-Thiol hydrochloride
|
Biochemical Assay Reagents
|
|
H2N-PEG3400-SH (Amine-PEG3400-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG3400-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-W1048545E
-
|
Amine-PEG20000-Thiol hydrochloride
|
Biochemical Assay Reagents
|
|
H2N-PEG20000-SH (Amine-PEG20000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG20000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-W1048545J
-
|
Amine-PEG40000-Thiol hydrochloride
|
Biochemical Assay Reagents
|
|
H2N-PEG40000-SH (Amine-PEG40000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG40000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
-
- HY-W1048545C
-
|
Amine-PEG5000-Thiol hydrochloride
|
Biochemical Assay Reagents
|
|
H2N-PEG5000-SH (Amine-PEG5000-Thiol) hydrochloride is a linear heterobifunctional PEGylated product containing thiol and amine. H2N-PEG5000-SH hydrochloride is an important cross-linking or bioconjugation reagent with PEG chains. Thiol or SH, sulfhydryl or thiol selectively reacts with maleimide, OPSS, vinyl sulfone and transition metal surfaces (including gold, silver, etc.) .
|
| Cat. No. |
Product Name |
Category |
Target |
Chemical Structure |
| Cat. No. |
Product Name |
Chemical Structure |
-
- HY-W701476
-
|
|
|
Ethyl phenylglyoxylate-d5 (Ethyl benzoylformate-d5; Phenylglyoxylic acid ethyl ester-d5) is the deuterium labeled Ethyl phenylglyoxylate (HY-W016618). Ethyl phenylglyoxylate (Ethyl benzoylformate), the ethyl ester of phenylglyoxylic acid, is used as a synthetic reagent. Ethyl phenylglyoxylate is also a poor substrate but a potent inhibitor of chicken liver carboxylesterase. Additionally, Ethyl phenylglyoxylate exhibits photoreactivity, where its excited triplet carbonyl can initiate intermolecular hydrogen abstraction, radical coupling and cross-linking reactions .
|
-
| Cat. No. |
Product Name |
|
Classification |
-
- HY-W035129
-
|
|
|
BCN
|
|
endo-BCN-NHS carbonate is an elastin-like protein (ELP) modification reagent. endo-BCN-NHS carbonate can react with lysine residues in ELP to make ELP carry BCN groups, and then cross-link ELP through strain-promoted azide-alkyne cycloaddition (SPAAC) reaction. endo-BCN-NHS carbonate promotes hydrogel formation. endo-BCN-NHS carbonate is mainly used in cell encapsulation related research .
|
-
- HY-145149
-
|
|
|
Azide
ADC Synthesis
|
|
Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].
|
-
- HY-151738
-
|
|
|
Azide
|
|
Fmoc-Aeg(N3)-OH is a click chemistry reagent containing an Azide. Alkylating the Nitrogen of an amide bond results in peptoid structures, which leads to conformational restrains, like N-methylation and allows backbone derivatisation. Altering cytotoxicity, bacterial cell selectivity and receptor pharmacology through formation of peptoid derivatives have been published for Cilengitide, Piscidin 1, and MC3, MC4 and MC5 receptor agonist. This building block enables design of macrocycles through intermolecular crosslinking or backbone stabilization through intermolecular ring-closure. This compound is a potential building block for the construction of (customized) peptide nucleic acids (PNAs) and for peptoid synthesis . Fmoc-Aeg(N3)-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
-
- HY-W127719
-
|
|
|
Azide
|
|
Photobiotin (acetate)It is a biological probe used to study biochemical processes such as protein interactions and enzymatic reactions. It is a molecule containing a photosensitive group, which can be combined with specific target molecules (such as proteins, nucleic acids, etc.) through photochemical cross-linking technology, so as to realize the labeling and detection of these molecules. During the photosensitive crosslinking process, Photobiotin (acetate)Can participate in the formation of covalent bonds and form stable compounds. In addition, the compound also has high biocompatibility and biological activity, so it is widely used in the field of biomedical research, such as enzymatic research, proteomics, western blotting and other aspects. Photobiotin (acetate) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
|
| Cat. No. |
Product Name |
Target |
Research Areas |
Chemical Structure |
-
- HY-128952G
-
|
SG3249
|
Drug-Linker Conjugates for ADC
DNA Alkylator/Crosslinker
|
Cancer
|
|
Tesirine (GMP) (SG3249 (GMP)) is Tesirine (HY-128952) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Tesirine (SG3249) is an antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. Tesirine combines potent antitumor activity with desirable physicochemical properties such as favorable hydrophobicity and improved conjugation characteristics. SG3199 (HY-101161) is the released warhead component of the ADC payload Tesirine. SG3199 retains picomolar activity in a panel of cancer cell lines. PBD dimers are highly efficient DNA minor groove cross-linking agents with potent cytotoxicity .
|
-
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