2. Search Result
Search Result
Results for "

emphysema

" in MedChemExpress (MCE) Product Catalog:

34

Inhibitors & Agonists

1

Biochemical Assay Reagents

4

Peptides

7

Natural
Products

1

Click Chemistry

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P2974
    Elastase, Porcine pancreas
    4 Publications Verification

    EC 3.4.21.36; Pancreatopeptidase E

    		 Elastase Metabolic Disease
    Elastase, Porcine pancreas (EC 3.4.21.36) is a single polypeptide chain of 240 amino acid residues, derived from pig pancreas. Elastase, Porcine pancreas is a serine protease that can hydrolyze proteins and polypeptide. Elastase from porcine pancreas can induce emphysema in hamsters .
    Elastase, Porcine pancreas
  • HY-P1645
    Papain
    10+ Cited Publications

    		 Cathepsin Cardiovascular Disease Inflammation/Immunology
    Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema .
    Papain
  • HY-B2237
    Lysozyme from chicken egg white
    5+ Cited Publications

    		 Bacterial HIV Infection
    Lysozyme from chicken egg white is a bactericidal enzyme, and it lyses gram-positive bacteria. Lysozyme from chicken egg white can also be used for the research of HIV infection and pulmonary emphysema .
    Lysozyme from chicken egg white
  • HY-B0128
    Diphylline
    1 Publications Verification

    Diprophylline

    		 Adenosine Receptor Phosphodiesterase (PDE) Cardiovascular Disease Inflammation/Immunology
    Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema .
    Diphylline
  • HY-136205
    IA-Alkyne
    4 Publications Verification

    Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide

    		 TRP Channel Infection Inflammation/Immunology
    IA-Alkyne (Iodoacetamide-alkyne; N-Hex-5-ynyl-2-iodo-acetamide) is a TRP channel (TRPC) agonist and has the potential for the study of respiratory infection . IA-Alkyne can be used to develop an isotopically tagged probe for quantitative cysteine-reactivity profiling . IA-Alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    IA-Alkyne
  • HY-B2237A
    Lysozyme chloride
    5+ Cited Publications

    		 Bacterial HIV Infection
    Lysozyme chloride is a bactericidal enzyme, and it lyses gram-positive bacteria. Lysozyme chloride can also be used for the research of HIV infection and pulmonary emphysema .
    Lysozyme chloride
  • HY-P1645A
    Papain (1.5-10 units/mg)

    		Cathepsin Cardiovascular Disease Inflammation/Immunology
    Papain (1.5-10 units/mg) is a cysteine protease of the peptidase C1 family. Papain (1.5-10 units/mg) enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain (1.5-10 units/mg) can induce pulmonary emphysema. Papain (1.5-10 units/mg) can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema .
    Papain (1.5-10 units/mg)
  • HY-124295
    Imofinostat

    ABT-301; MPT0E028; TMU-C-0012

    		 HDAC Akt Apoptosis Inflammation/Immunology Cancer
    Imofinostat (ABT-301; MPT0E028) is an orally active and selective HDAC inhibitor with IC50s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively. Imofinostat has a weak inhibitory effect on HDAC8 (IC50 of 2.5 ​​μM), but no inhibitory effect on HDAC4 (IC50>10 μM). Imofinostat reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. Imofinostat has a broad-spectrum antitumor activity, including colorectal cancer, B-cell lymphoma, non-small cell lung carcinoma (NSCLC), and pancreatic cancer, while also showing therapeutic potential in non-tumor diseases like emphysema and pulmonary fibrosis .
    Imofinostat
  • HY-113953
    Z-Asp-CH2-DCB

    		Caspase Apoptosis Inflammation/Immunology
    Z-Asp-CH2-DCB is an irreversible broad spectrum caspase inhibitor. Z-Asp-CH2-DCB also inhibits proteases with caspase-like activity. Z-D-CH2-DCB blocks the production of IL-1β, TNF-α, IL-6, and IFN-γ in staphylococcal enterotoxin B (SEB)-stimulated peripheral blood mononuclear cells (PBMC), and reduces SEB-1-stimulated T-cell proliferation in a dose-dependent manner. Z-Asp-CH2-DCB prevents SU5416-induced septal cell apoptosis and emphysema development .
    Z-Asp-CH2-DCB
  • HY-17428
    Tripelennamine hydrochloride

    		Histamine Receptor Neurological Disease Inflammation/Immunology
    Tripelennamine hydrochloride is a histamine H1-receptor antagonist. Tripelennamine hydrochloride effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine hydrochloride does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine hydrochloride exhibits local and central analgesic activity. Tripelennamine hydrochloride can be used in studies related to emphysema, urticaria and acute laminitis .
    Tripelennamine hydrochloride
  • HY-P1645B
    Papain (lyophilized powder, ≥10 units/mg protein)

    		Cathepsin Cardiovascular Disease Inflammation/Immunology
    Papain (lyophilized powder, ≥10 units/mg protein) is a cysteine protease of the peptidase C1 family. Papain (lyophilized powder, ≥10 units/mg protein) enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain (lyophilized powder, ≥10 units/mg protein) can induce pulmonary emphysema. Papain (lyophilized powder, ≥10 units/mg protein) can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema .
    Papain (lyophilized powder, ≥10 units/mg protein)
  • HY-P3293
    Lonodelestat

    POL6014

    		 Elastase Inflammation/Immunology
    Lonodelestat (POL6014) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat (POL6014) has the potential for the research of cystic fibrosis (CF) .
    Lonodelestat
  • HY-B1481
    Isoetharine mesylate

    Isoetarine mesylate

    		 Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology
    Isoetharine (Isoetarine) mesylate is an orally active selective agonist of β-adrenergic receptors. Isoetharine mesylate is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine mesylate can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator .
    Isoetharine mesylate
  • HY-130391
    MMP12-IN-3

    		MMP Inflammation/Immunology
    MMP12-IN-3 (compound 32) is a potent MMP12 inhibitor with an IC50 value of 4.9 nM. MMP12-IN-3 has the potential for the research of chronic respiratory diseases such as emphysema .
    MMP12-IN-3
  • HY-120039A
    (S)-MDL-101146

    		Elastase Inflammation/Immunology
    (S)-MDL-101146 is the S-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis .
    (S)-MDL-101146
  • HY-W097753
    4-MDM

    4-Methoxydiphenylmethane

    		 Aminopeptidase Others
    4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A4 Hydrolase (LTA4H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by LTA4H, thereby reducing inflammation, and does not affect the epoxy-hydrolase activity of LTA4H. 4-MDM can be used for research on lung diseases .
    4-MDM
  • HY-P3293A
    Lonodelestat TFA

    POL6014 TFA

    		 Elastase Inflammation/Immunology
    Lonodelestat TFA (POL6014 TFA) is a potent, orally active and selective peptide inhibitor of human neutrophil elastase (hNE). Lonodelestat TFA has the potential for the research of cystic fibrosis (CF) .
    Lonodelestat TFA
  • HY-B1481A
    Isoetharine

    Isoetarine

    		 Adrenergic Receptor Cardiovascular Disease Inflammation/Immunology
    Isoetharine (Isoetarine) is an orally active selective agonist of β-adrenergic receptors. Isoetharine is a catechol-like agent and catechol O-methyltransferase (COMT) mediates its methylation. Isoetharine can promote the production of cAMP which stimulates the relaxation of smooth muscle cells and can be used as an emphysema, bronchitis and bronchodilator .
    Isoetharine
  • HY-120039
    (R)-MDL-101146

    		Elastase Inflammation/Immunology
    (R)-MDL-101146 is the R-isomer of MDL-101146. MDL-101146 is an orally active, competitive and reversible inhibitor against human neutrophil elastase (HNE) with a Ki value of 25 nM. MDL-101146 inhibits HNE-induced hemorrhage in hamsters. MDL-101146 is promising for research of emphysema, rheumatoid arthritis, chronic bronchitis, cystic fibrosis, adult respiratory distress syndrome and glomerulonephritis .
    (R)-MDL-101146
  • HY-165407
    Neltenexine

    		Elastase CFTR Inflammation/Immunology
    Neltenexine, a mucolytic agent, is an Elastase inhibitor. Neltenexine diminishes anion secretion in in bronchial epithelial cells by inhibiting the Cl− and HCO3- uptake via Na/K/2Cl++− and Na+/HCO3- cotransporter without blockade of the CFTR channel, and also diminishes anion secretion via stimulation of Cl−/HCO3- exchanger. Neltenexine significantly prevents pulmonary emphysema with a reduction of alveolar deformation in rat models induced by Elastase. Neltenexine can be used for lung diseases such as chronic obstructive pulmonary disease (COPD) research .
    Neltenexine
  • HY-138570
    HLE-IN-1

    		Elastase Inflammation/Immunology
    HLE-IN-1 (Compound 4) is a human leukocyte elastase HLE inhibitor (Ki=1.8 nM). HLE-IN-1 is used in emphysema and inflammamry pulmonary research .
    HLE-IN-1
  • HY-167891
    GPD-1116

    		Phosphodiesterase (PDE) Apoptosis Inflammation/Immunology
    GPD-1116 is an orally active Phosphodiesterase (PDE) 4 and PDE1 inhibitor. GPD-1116 can reduce smoke-induced apoptosis of lung cells. GPD-1116 is effective in several disease models in animals, including emphysema, acute lung injury, chronic obstructive pulmonary disease (COPD), asthma and pulmonary hypertension .
    GPD-1116
  • HY-100250
    Spirofylline

    		Nucleoside Antimetabolite/Analog Inflammation/Immunology
    Spirofylline is a bronchodilator that has the potential for asthma and bronchitis and emphysema treatment.
    Spirofylline
  • HY-121185A
    Hexoprenaline sulfate

    		Adrenergic Receptor Infection Neurological Disease Inflammation/Immunology Endocrinology
    Hexoprenaline sulfate is an orally active and selective β-adrenergic receptor agonist. Hexoprenaline sulfate can dilate the bronchi. Hexoprenaline sulfate can activate adenylate cyclase and increases 14C-Aminopyrine uptake. Hexoprenaline sulfate exhibits anti-infection and anti-inflammmation effect. Hexoprenaline sulfate can increase placental weight and blood flow. Hexoprenaline sulfate can be used for the researches of inflammation, immunology, infection, endocrinology and neurological disease, such as asthma, chronic bronchitis, sepsis and intoxication of organophosphorus compounds .
    Hexoprenaline sulfate
  • HY-B0128R
    Diphylline (Standard)

    Diprophylline (Standard)

    		 Reference Standards Adenosine Receptor Phosphodiesterase (PDE) Cardiovascular Disease Inflammation/Immunology
    Diphylline (Standard) is the analytical standard of Diphylline. This product is intended for research and analytical applications. Diphylline (Diprophylline) is a potent A1/A2 adenosine receptor antagonist and cyclic nucleotide phosphodiesterase inhibitor. Diphylline, a xanthine derivative, is a bronchodilator and vasodilator agent and has the potential for chronic bronchitis and emphysema .
    Diphylline (Standard)
  • HY-B1481B
    Isoetharine hydrochloride

    Isoetarine hydrochloride

    		 Adrenergic Receptor Infection
    Isoetharine hydrochloride is selective, short-acting and orally active β-agonist which is widely used as a bronchodilator in the research of inhalation research .
    Isoetharine hydrochloride
  • HY-17428A
    Tripelennamine

    		Histamine Receptor Neurological Disease Inflammation/Immunology
    Tripelennamine is a histamine H1-receptor antagonist. Tripelennamine effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine exhibits local and central analgesic activity. Tripelennamine can be used in studies related to emphysema, urticaria and acute laminitis .
    Tripelennamine
  • HY-17428B
    Tripelennamine citrate

    		Histamine Receptor Neurological Disease Inflammation/Immunology
    Tripelennamine citrate is a histamine H1-receptor antagonist. Tripelennamine citrate effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine citrate does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine citrate exhibits local and central analgesic activity. Tripelennamine citrate can be used in studies related to emphysema, urticaria and acute laminitis .
    Tripelennamine citrate
  • HY-17428R
    Tripelennamine hydrochloride (Standard)

    		Reference Standards Histamine Receptor Neurological Disease Inflammation/Immunology
    Tripelennamine hydrochloride (Standard) is the analytical standard of Tripelennamine hydrochloride (HY-17428). This product is intended for research and analytical applications. Tripelennamine hydrochloride is a histamine H1-receptor antagonist. Tripelennamine hydrochloride effectively reverses histamine-induced bronchoconstriction, increased transpulmonary pressure, elevated pulmonary vascular resistance and reduced dynamic compliance. Tripelennamine hydrochloride does not significantly affect arterial hypoxemia, hemoglobin desaturation and hypercapnia in horses undergoing short-term high-intensity exercise. Tripelennamine hydrochloride exhibits local and central analgesic activity. Tripelennamine hydrochloride can be used in studies related to emphysema, urticaria and acute laminitis .
    Tripelennamine hydrochloride (Standard)
  • HY-P10854
    TAT-N15

    		NF-κB Interleukin Related STAT Akt Neurological Disease Inflammation/Immunology
    TAT-N15 is a p55PIK inhibitor with remarkable anti-inflammatory activity and neuroprotective effects. TAT-N15 can significantly inhibit the activation of IL-6, IL-8, Akt, and NF-κB pathways, as well as suppress the protein expression of phosphorylated STAT3 and NF-κB. By inhibiting the activation of Akt, STAT3, and NF-κB pathways, TAT-N15 is used in research on acute conjunctivitis, allergic rhinitis, chronic obstructive pulmonary disease (COPD), and stroke .
    TAT-N15
  • HY-E71363
    papain (USP)

    		Cathepsin Cardiovascular Disease Inflammation/Immunology
    Papain (USP) refers to Papain (HY-P1645) that meets the standards of the US Pharmacopoeia. Papain is a cysteine protease of the peptidase C1 family. Papain enhances red cell agglutination by anti-D and anti-A, and increases red cell sensitivity to K cell-mediated lysis in ADCC assays. Papain can induce pulmonary emphysema. Papain can be used for the researches of Rh haemolytic disease of the newborn and pulmonary emphysema .
    papain (USP)
  • HY-153149
    LJ-2698

    		Adenosine Receptor Apoptosis PGC-1α Metabolic Disease Inflammation/Immunology
    LJ-2698 is an orally active adenosine A3 receptor antagonist. LJ-2698 induces increased levels of anti-inflammatory cytokines in macrophages and significantly elevates the number of anti-inflammatory M2 macrophages in the lung. LJ-2698 prevents alveolar cavity enlargement, restores pulmonary function, inhibits matrix metalloproteinase activity and pulmonary cell apoptosis in the lung tissues of mice. LJ-2698 prevents renal injury, inhibits renal lipid accumulation, and increases PGC1α levels in renal tissues of mice with diabetic nephropathy. LJ-2698 is applicable to the research of emphysema and diabetic nephropathy .
    LJ-2698
  • HY-181762
    Multitarget AD-IN-6

    		Phosphodiesterase (PDE) TRP Channel NF-κB NOD-like Receptor (NLR) Interleukin Related Inflammation/Immunology
    Multitarget AD-IN-6 (Compound 39) is a multi-target inhibitor, with an IC50 of 15.54 μM against PDE4B, 15.15 μM against PDE7A, 8.39 μM against PDE3A, and a Kd of 37.7 μM against CHIT1. Multitarget AD-IN-6 acts as a TRPA1 antagonist, reduces the level of the NLRP3 inflammasome multiprotein complex to inhibit its activation, while inhibiting PDE4B, PDE7A and CHIT1, and decreasing the phosphorylation of NF-κB. Multitarget AD-IN-6 improves the pathology of elastase-induced emphysema in mice. Multitarget AD-IN-6 is applicable for the research of chronic obstructive pulmonary disease .
    Multitarget AD-IN-6
  • HY-P11787
    Eglin c (60-63)

    		Elastase Inflammation/Immunology
    Eglin c (60-63) is a selective Elastase inhibitor, with a Ki value of 2.3e-3 M against human leukocyte hElastase and a Ki value of 4.8e-3 M against porcine pancreatic Elastase. Eglin c (60-63) can be used in research related to rheumatoid arthritis .
    Eglin c (60-63)

Inquiry Online

Your information is safe with us. * Required Fields.

Salutation

  

Country or Region *

Applicant Name *

 

Organization Name *

Department *

     

Email Address *

 

Product Name *

Cat. No.

  

Requested quantity *

Phone Number *

     

Remarks

Inquiry Online

Inquiry Information

Product Name:
Cat. No.:
Quantity:
MCE Japan Authorized Agent: