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forced

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (6) Adenosine Receptor (2) Adrenergic Receptor (3) Amyloid-β (1) Antibiotic (1) Bacterial (1) Cholinesterase (ChE) (1) Dopamine Receptor (1) Dopamine Transporter (5) Drug Derivative (2) Drug Metabolite (1) GABA Receptor (2) GSK-3 (1) Histamine Receptor (3) iGluR (3) Interleukin Related (1) mGluR (1) Monoamine Oxidase (4) nAChR (4) Opioid Receptor (7) Phosphodiesterase (PDE) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (4) Serotonin Transporter (5)
By Research Areas:	Cardiovascular Disease (3) Infection (2) Inflammation/Immunology (3) Metabolic Disease (2) Neurological Disease (35)

By Targets:

5-HT Receptor (6)

Adenosine Receptor (2)

Adrenergic Receptor (3)

Amyloid-β (1)

Antibiotic (1)

Bacterial (1)

Cholinesterase (ChE) (1)

Dopamine Receptor (1)

Dopamine Transporter (5)

Drug Derivative (2)

Drug Metabolite (1)

GABA Receptor (2)

GSK-3 (1)

Histamine Receptor (3)

iGluR (3)

Interleukin Related (1)

mGluR (1)

Monoamine Oxidase (4)

nAChR (4)

Opioid Receptor (7)

Phosphodiesterase (PDE) (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (4)

Serotonin Transporter (5)

By Research Areas:

Cardiovascular Disease (3)

Infection (2)

Inflammation/Immunology (3)

Metabolic Disease (2)

Neurological Disease (35)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1395

Mecamylamine hydrochloride 5 Publications Verification	nAChR Histamine Receptor	Cardiovascular Disease Neurological Disease
Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area .

HY-18698

L-701324	iGluR	Neurological Disease
L-701324 is a potent, orally active NMDA receptor antagonist that antagonizes the activity of the NMDA receptor by blocking its glycine B binding site. L-701324 binds with high affinity to rat brain membranes (IC₅₀=2 nM). L-701324 has antidepressant activity .

HY-103151

CP94253 hydrochloride	5-HT Receptor	Neurological Disease Metabolic Disease
CP94253 hydrochloride is an orally active, brain-penetrant and selective 5-HT_1B receptor agonist with an K_i of 2 nM. CP94253 hydrochloride induces antidepressant-like effects, waking enhancement, sleep inhibition, increased sleep latency, hyperlocomotion, and suppressed aggressive behavior. CP94253 hydrochloride can be used for the research of depression and heightened aggressive behavior .

HY-101955A

(2R,6R)-Hydroxynorketamine hydrochloride (2R,6R)-HNK hydrochloride	Drug Metabolite	Neurological Disease
(2R,6R)-Hydroxynorketamine ((2R,6R)-HNK) hydrochloride is an active ketamine metabolite with no NMDAR binding activity. (2R,6R)-Hydroxynorketamine hydrochloride rescues impaired dorsal hippocampal long-term potentiation and restores robust long-term potentiation in the hippocampal SC-CA1 pathway. (2R,6R)-Hydroxynorketamine hydrochloride can be used for research on depression .

HY-P1173

L803-mts Myristoylated L 803; GSK-3β Inhibitor XIII	GSK-3 Amyloid-β	Neurological Disease
L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC₅₀: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test .

HY-14196

Toloxatone 1 Publications Verification MD 69276	Monoamine Oxidase	Neurological Disease
Toloxatone (MD 69276) is a reversible, selective MAO-A inhibitor that can cross the blood-brain barrier. Toloxatone increases the levels of serotonin (5-HT) and norepinephrine in the brain. Toloxatone reduces the immobility time in the forced swimming test in mice, inhibits killing behavior in rats without causing sedation, and shows a correlation between its free plasma concentration and cerebrospinal fluid concentration. Toloxatone is widely used in research related to depression, depressive disorders and Parkinson's disease .

HY-12392

Iprindole	Opioid Receptor	Neurological Disease
Iprindole, an opioid receptor agonist, is a tricyclic antidepressant. Iprindole shortens the immobility time in mice forced swimming test, which can be reversed by the opiate antagonist Naloxone (HY-17417A). Iprindole induces lamellar body formation but devoid of lamellar bodies. Iprindole can be used for the research of depression .

HY-W004425

DMPX 3,7-Dimethyl-1-propargylxanthine	Adenosine Receptor	Neurological Disease
DMPX (3,7-Dimethyl-1-propargylxanthine) is a selective A_2A adenosine receptor (A_2A AR) antagonist that crosses the blood-brain barrier, with a K_i of 11 μM for rat A₂ adenosine receptor and a K_i of 45 μM for rat A₁ adenosine receptor. By blocking A2A receptors in specific brain regions, DMPX protects dopaminergic and GABAergic neurons from mitochondrial dysfunction. DMPX is applicable to research related to depression, Parkinson's disease and Huntington's disease .

HY-107750A

Cyprodime hydrochloride	Opioid Receptor	Neurological Disease
Cyprodime hydrochloride is a highly selective μ-opioid receptor antagonist with K_i values of 5.4 nM, 244.6 nM and 2187 nM for μ-, δ- and κ-opioid receptors, respectively. Cyprodime hydrochloride has anti-depressant-like effect .

HY-18332A

Amitifadine hydrochloride DOV-21947 hydrochloride; EB-1010 hydrochloride	Serotonin Transporter Dopamine Transporter	Infection Neurological Disease
Amitifadine (DOV-21947; EB-1010) hydrochloride is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC₅₀s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

HY-139748

ETX0462	Antibiotic Bacterial	Infection
S32212 is a serotonin type 2C receptor inverse agonist and an α2 adrenoceptor antagonist. S32212 exhibits antidepressant activity and can reduce immobility time in forced-swim test in rats .

HY-P1299A

UFP-101 TFA	Opioid Receptor	Neurological Disease
UFP-101 TFA is a potent, selective, and competitive antagonist of the N/OFQ peptide (NOP) receptor, with a pK_i of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect .

HY-18332C

DOV-216,303 Free Base	Serotonin Transporter Dopamine Transporter	Neurological Disease
DOV-216,303 (Free Base) is a potent triple serotonin, norepinephrine, and dopamine reuptake inhibitor, with IC₅₀ values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats .

HY-B1395A

Mecamylamine	nAChR Histamine Receptor	Cardiovascular Disease Neurological Disease
Mecamylamine is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine is also a ganglionic blocker. Mecamylamine can across the blood-brain barrier. Mecamylamine can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area .

HY-129807

LY-228729	5-HT Receptor	Neurological Disease
LY-228729 is a selective 5-HT1A receptor agonist. LY-228729 can reduce the rearing frequency of rats and decrease their activity in the central area in the open field test. LY-228729 can reduce the immobility time of rats and increase their swimming time in the forced swim test. LY-228729 can be used in the research of neurological diseases .

HY-13974

S32212	Adrenergic Receptor	Neurological Disease
S32212 is a serotonin type 2C receptor inverse agonist and an 2 adrenoceptor antagonist. S32212 exhibits antidepressant activity and can reduce immobility time in forced-swim test in rats .

HY-137570

Ethyl homovanillate	Monoamine Oxidase	Neurological Disease
Ethyl homovanillate (Compound 24) is an structural analog of Eugenol. Ethyl homovanillate is an inhibitor of monoamine oxidase A (MAOA) with an IC₅₀ of 8.1 μM. Ethyl homovanillate significantly increases the forced swim test score in ICR mice. Ethyl homovanillate can be studied in research on neurological diseases such as Alzheimer’s disease .

HY-P1299

UFP-101	Opioid Receptor	Neurological Disease
UFP-101 is a potent, selective, and competitive antagonist of the NOP receptor, with a pK_i of 10.24. UFP-101 displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 shows antidepressant-like effect .

HY-W052508R

Norquetiapine (Standard) N-Desalkylquetiapine (Standard)	5-HT Receptor Reference Standards	Neurological Disease
Norquetiapine is an antidepressant and neuroprotective agent and is the active metabolic component of Quetiapine (HY-14544). Norquetiapine is also a partial 5-HT1A receptor agonist, and a presynaptic α2, 5-HT2C and 5-HT7 b> Receptor antagonist. Norquetiapine can also selectively inhibit norepinephrine transporter (NET), inhibit norepinephrine reuptake, and has potential inhibitory effects on bipolar depression, major depressive disorder, and generalized anxiety disorder. Norquetiapine demonstrated in vivo activity in forced swimming in mice and learned helplessness tests in rats .

HY-18332B

DOV-102,677	Dopamine Transporter Adrenergic Receptor 5-HT Receptor	Neurological Disease
DOV-102,677 is an orally sctive triple monoamine neurotransmitter reuptake inhibitor that simultaneously inhibits the dopamine (DAT) (IC₅₀ = 129 nM; K_i = 222 nM), norepinephrine (NET) (IC₅₀ = 103 nM; K_i = 1030 nM), and serotonin (SERT) (IC₅₀ = 133 nM; K_i = 740 nM) transporters. DOV-102,677 demonstrated significant antidepressant-like activity and sensory-motor gating regulatory effects in mouse experiments. DOV-102,677 can be used for research on depression .

HY-170945

Antidepressant agent 9	iGluR Serotonin Transporter	Neurological Disease
Antidepressant agent 9 (Compound 24) is an orally active and BBB-penetrable NMDAR and SERT inhibitor with IC₅₀ values of 3.50 μM and 1044 nM, respectively. Antidepressant agent 9 has good metabolic stability and plasma exposure. Antidepressant agent 9 can exert antidepressant-like activity in the mouse forced swim test .

HY-158767

Dehydro amlodipine fumarate	Drug Derivative	Others
Dehydro amlodipine fumarate is a derivative of Dehydro amlodipine and is one of the forced degradation products of Dehydro amlodipine during oxidation and acid degradation .

HY-12392R

Iprindole (Standard)	Reference Standards Opioid Receptor	Neurological Disease
Iprindole (Standard) is the analytical standard of Iprindole. This product is intended for research and analytical applications. Iprindole, an opioid receptor agonist, is a tricyclic antidepressant. Iprindole shortens the immobility time in mice forced swimming test, which can be reversed by the opiate antagonist Naloxone (HY-17417A). Iprindole induces lamellar body formation but devoid of lamellar bodies. Iprindole hydrochloride can be used for the research of depression .

HY-100679B

(R)-Pirlindole mesylate	Monoamine Oxidase	Neurological Disease
(R)-Pirlindole mesylate is selective and reversible a Monoamine oxidase A (MAO-A) inhibitor with an IC₅₀ of 0.43  μM for MAO-A over MAO-B. (R)-Pirlindole mesylate has an antidepressant activity. (R)-Pirlindole mesylate significantly decreases immobility time of the forced swim test and inhibits Reserpine (HY-N0480)-induced palpebral ptosis in behavioural mice models. (R)-Pirlindole mesylate can be used for depression research .

HY-147735

GABAA receptor agonist 1	GABA Receptor	Neurological Disease
GABAA receptor agonist 1 (compound 3e) is a potent GABAA receptor agonist. GABAA receptor agonist 1 shows anti-depression activities in classical mouse models of depression of FST and TST. GABAA receptor agonist 1 binds at the GABA binding site of GABAA receptor in order to produce GABAergic effects. GABAA receptor agonist 1 has the potential for the research of depression .

HY-118285

Ro4491533	mGluR	Neurological Disease
Ro4491533 is a selective, negative allosteric mGluR2/3 receptor modulator that is equally effective on both subtypes. Ro4491533 can completely block glutamate-induced calcium mobilization and glutamate-induced [35S]GTPγS binding accumulation. Ro4491533 has good pharmacokinetic properties in mice and rats, high oral bioavailability, and can pass through the blood-brain barrier. Ro4491533 can also reverse the motor inhibition effect of LY379268 in mice and show antidepressant activity in the forced swim test and tail suspension test.

HY-120246

GS-5759	Adrenergic Receptor Phosphodiesterase (PDE)	Inflammation/Immunology
GS-5759 is both a β₂-adrenergic receptor agonist and a PDE4 inhibitor. GS-5759 increases intracellular cAMP levels by activating the β₂ receptor, promoting bronchial dilation. GS-5759 inhibits PDE4 activity, reduces cAMP degradation, and enhances anti-inflammatory effects. GS-5759 exhibits potent bronchial dilation and anti-inflammatory capabilities in animal models. GS-5759 can be used for research on respiratory diseases such as chronic obstructive pulmonary disease (COPD) .

HY-147736

GABAA receptor agonist 2	GABA Receptor	Neurological Disease
GABAA receptor agonist 2 (compound 4c) is a potent GABAA receptor agonist. GABAA receptor agonist 2 shows anti-depression activities in classical mouse models of depression of FST and TST. GABAA receptor agonist 2 binds at the GABA binding site of GABAA receptor in order to produce GABAergic effects. GABAA receptor agonist 2 has the potential for the research of depression .

HY-18332

Amitifadine DOV-21947; EB-1010	Serotonin Transporter Dopamine Transporter Dopamine Receptor	Neurological Disease
Amitifadine (DOV-21947; EB-1010) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC₅₀s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

HY-B1395R

Mecamylamine hydrochloride (Standard)	Reference Standards nAChR Histamine Receptor	Cardiovascular Disease Neurological Disease
Mecamylamine (hydrochloride) (Standard) is the analytical standard of Mecamylamine (hydrochloride). This product is intended for research and analytical applications. Mecamylamine hydrochloride is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine hydrochloride is also a ganglionic blocker. Mecamylamine hydrochloride can across the blood-brain barrier. Mecamylamine hydrochloride can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area .

HY-103117

S 32212 hydrochloride	5-HT Receptor	Neurological Disease
S 32212 hydrochloride is an inverse agonist of 5-HT receptors 5-HT2(CINI) and 5-HT2(CVSV) (Kis=6.6, 8.9 nM) and an antagonist of 5-HT2A and α2β-adrenergic receptors (Ki=5.8, 5.8 nM). S 32212 hydrochloride can reduce the binding of GTPγS to Gαq, and reduce the activity of phospholipase C (PLC) in HEK293 cells expressing 5-HT2(CINI) receptor and CHO cells expressing 5-HT2(CVSV) receptor (EC₅₀=38 and 18.6 nM, respectively). S 32212 hydrochloride (2.5 mg/kg) reduces 5-HT receptor agonist-induced head twitches and penile erections in mice and rats. S 32212 hydrochloride (10, 40 mg/kg) reduces immobility time in the forced swim test and marble burying behavior in mice and rats, exerting antidepressant and anxiolytic activities.

HY-103151A

CP94253	5-HT Receptor	Neurological Disease Metabolic Disease
CP94253 is an orally active, brain-penetrant and selective 5-HT_1B receptor agonist with an K_i of 2 nM. CP94253 induces antidepressant-like effects, waking enhancement, sleep inhibition, increased sleep latency, hyperlocomotion, and suppressed aggressive behavior. CP94253 can be used for the research of depression and heightened aggressive behavior .

HY-158767R

Dehydro amlodipine fumarate (Standard)	Drug Derivative Reference Standards	Others
Dehydro amlodipine (fumarate) (Standard) is the analytical standard of Dehydro amlodipine (fumarate). This product is intended for research and analytical applications. Dehydro amlodipine fumarate is a derivative of Dehydro amlodipine and is one of the forced degradation products of Dehydro amlodipine during oxidation and acid degradation .

HY-12392A

Iprindole hydrochloride	Opioid Receptor	Neurological Disease
Iprindole hydrochloride, an opioid receptor agonist, is a tricyclic antidepressant. Iprindole hydrochloride shortens the immobility time in mice forced swimming test, which can be reversed by the opiate antagonist Naloxone (HY-17417A). Iprindole hydrochloride induces lamellar body formation but devoid of lamellar bodies. Iprindole hydrochloride can be used for the research of depression .

HY-180212A

SYK-1106 dihydrochloride	Opioid Receptor	Neurological Disease
SYK-1106 dihydrochloride is a selective δ opioid receptor (DOR) agonist with an EC₅₀ of 0.089 nM. SYK-1106 dihydrochloride shows high selectivity over MOR and KOR. SYK-1106 dihydrochloride exhibits antidepressant-like effects in the mouse forced-swimming tests. SYK-1106 dihydrochloride can be used for the research of depression .

HY-183666

NS3956	nAChR Serotonin Transporter	Neurological Disease
NS3956 is a blood-brain barrier-permeable human α4β2-nicotinic acetylcholine receptor (nAChR) agonist (K_i = 0.36 nM). NS3956 induces dopamine release, produces analgesic effects, modulates rotational behavior in 6-OHDA-lesioned rats, and potentiates the effects of SSRI/SNRI in the forced swim test in mice. NS3956 can be used in research related to depression, Parkinson's disease, and acute pain .

HY-181110

MAO-A-IN-4	Monoamine Oxidase Reactive Oxygen Species (ROS) Cholinesterase (ChE) Interleukin Related	Neurological Disease Inflammation/Immunology
MAO-A-IN-4 is a highly selective and reversible inhibitor of monoamine oxidase A (MAO-A), with an IC₅₀ of 0.06 μM against hMAO-A. MAO-A-IN-4 exhibits anti-inflammatory, antioxidant, neuroprotective, and antidepressant activities. MAO-A-IN-4 possesses favorable ADME properties and is suitable for research related to depression .

HY-183324

AMPA receptor modulator-12	iGluR Dopamine Transporter	Neurological Disease
AMPA receptor modulator-12 is an orally acrive AMPA receptor positive allosteric modulator. AMPA receptor modulator-12 also exhibits moderate binding affinity for the human dopamine transporter with a K_d of 1.57 μM. AMPA receptor modulator-12 enhances AMPA receptor-mediated ion currents, delays channel deactivation. AMPA receptor modulator-12 prolongs sleep latency, reduces sleep duration, extends forced swimming time, improves rotarod endurance, and alleviates acute sleep deprivation-related behavioral deficits. AMPA receptor modulator-12 does not increase spontaneous locomotion. AMPA receptor modulator-12 can be used for the research of narcolepsy and fatigue-related conditions .

HY-180423

IRFI-165	Adenosine Receptor	Neurological Disease
IRFI-165 is a potent and selective A₁ adenosine receptor antagonist with a K_i of 7.9 nM for rat A₁ AR. IRFI-165 exhibies high selectivity versus A_2A and A₃ receptors. IRFI-165 induces antidepressant activity in vivo. IRFI-165 can be used for the research of psychiatric and neurological disorders .

Cat. No.	Product Name	Target	Research Area

HY-P1173

L803-mts Myristoylated L 803; GSK-3β Inhibitor XIII	GSK-3 Amyloid-β	Neurological Disease
L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC₅₀: 40 μM). L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test .

HY-P1299A

UFP-101 TFA	Opioid Receptor	Neurological Disease
UFP-101 TFA is a potent, selective, and competitive antagonist of the N/OFQ peptide (NOP) receptor, with a pK_i of 10.24. UFP-101 TFA displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 TFA shows antidepressant-like effect .

HY-P1299

UFP-101	Opioid Receptor	Neurological Disease
UFP-101 is a potent, selective, and competitive antagonist of the NOP receptor, with a pK_i of 10.24. UFP-101 displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 shows antidepressant-like effect .

Cat. No.	Product Name	Target	Research Area	Image

HY-P992359

GSK5784283 SHR-1905	Inhibitory Antibodies	Inflammation/Immunology
GSK5784283 (SHR-1905) is a bispecific epitope antibody against TSLP that can be used in research related to asthma. GSK5784283 effectively reduces the levels of eosinophils, FeNO, TARC and eotaxin-3. GSK5784283 regulates FEV1 (forced expiratory volume in 1 second) .

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