60-40-2
60-40-2
Chemical Structure
Mecamylamine
- CAS No.: 60-40-2
- Formula:C11H21N
- Molecular Weight:167.29
IUPAC Name: N,2,3,3-tetramethylbicyclo[2.2.1]heptan-2-amine
InChIKey: IMYZQPCYWPFTAG-UHFFFAOYSA-N
SMILES: CC1(C)C(NC)(C)C2CCC1C2
Biological Activity: Mecamylamine is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine is also a ganglionic blocker. Mecamylamine can across the blood-brain barrier. Mecamylamine can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area[1][2][5].
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Mecamylamine | Mecamylamine is an orally active, nonselective, noncompetitive nAChR antagonist. Mecamylamine is also a ganglionic blocker. Mecamylamine can across the blood-brain barrier. Mecamylamine can be used in the research of neuropsychiatric disorders, hypertension, antidepressant area. | |||||||||||||||||||||
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References
- [1]. Omar Hernández-González, et al. Mechanisms of stimulatory effects of mecamylamine on the dorsal raphe neurons. Brain Res Bull. 2020 Nov;164:289-298. [Content Brief]
- [2]. C P Robinson, et al. The influence of mecamylamine on contractions induced by different agonists and on the role of calcium ions in the isolated rabbit aorta. J Pharmacol Exp Ther. 1976 Apr;197(1):57-65. [Content Brief]
- [5]. Rabenstein RL, et al. The nicotinic antagonist mecamylamine has antidepressant-like effects in wild-type but not beta2- or alpha7-nicotinic acetylcholine receptor subunit knockout mice. Psychopharmacology (Berl). 2006 Dec;189(3):395-401. [Content Brief]
