29218-27-7
Chemical Structure
Toloxatone
Synonym(s): MD 69276
- CAS No.: 29218-27-7
- Formula:C11H13NO3
- Molecular Weight:207.23
IUPAC Name: 5-(hydroxymethyl)-3-(m-tolyl)oxazolidin-2-one
InChIKey: MXUNKHLAEDCYJL-UHFFFAOYSA-N
SMILES: CC1=CC(N2C(OC(CO)C2)=O)=CC=C1
Biological Activity: Toloxatone (MD 69276) is a reversible, selective MAO-A inhibitor that can cross the blood-brain barrier. Toloxatone increases the levels of serotonin (5-HT) and norepinephrine in the brain. Toloxatone reduces the immobility time in the forced swimming test in mice, inhibits killing behavior in rats without causing sedation, and shows a correlation between its free plasma concentration and cerebrospinal fluid concentration. Toloxatone is widely used in research related to depression, depressive disorders and Parkinson's disease[1][2][3][4].
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Toloxatone | 98.11% | Toloxatone (MD 69276) is a reversible, selective MAO-A inhibitor that can cross the blood-brain barrier. Toloxatone increases the levels of serotonin (5-HT) and norepinephrine in the brain. Toloxatone reduces the immobility time in the forced swimming test in mice, inhibits killing behavior in rats without causing sedation, and shows a correlation between its free plasma concentration and cerebrospinal fluid concentration. Toloxatone is widely used in research related to depression, depressive disorders and Parkinson's disease. | ||||||||||||||||||||
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- [1]. Goldstein DS, et al. Comparison of Monoamine Oxidase Inhibitors in Decreasing Production of the Autotoxic Dopamine Metabolite 3,4-Dihydroxyphenylacetaldehyde in PC12 Cells. J Pharmacol Exp Ther. 2016;356(2):483-492. [Content Brief]
- [2]. Vistelle R, et al. Toloxatone pharmacokinetics in the plasma and cerebrospinal fluid of the rabbit. J Pharm Pharmacol. 1992;44(2):124-126. [Content Brief]
- [3]. Isel F, et al. Alterations of serotonin neurotransmission and inhibition of mouse killing behavior: II. Effects of selective and reversible monoamine oxidase inhibitors of type A. Pharmacol Biochem Behav. 1988;29(1):97-104. [Content Brief]
- [4]. Van der Meersch-Mougeot V, et al. Benzodiazepines reverse the anti-immobility effect of antidepressants in the forced swimming test in mice. Neuropharmacology. 1993;32(5):439-446. [Content Brief]
Keywords
