(R)-4-Benzyl-2-oxazolidinone

Name: (R)-4-Benzyl-2-oxazolidinone
Brand: MedChemExpress
SKU: HY-W007664
Rating: 4.5 (0 reviews)

Cat. No.: HY-W007664 Purity: 99.73%: Data Sheet
COA

SDS
Handling Instructions
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(R)-4-Benzyl-2-oxazolidinone is an oxazolidinone-type auxiliary that enables highly stereoselective asymmetric alkylation reactions. (R)-4-Benzyl-2-oxazolidinone is applied in the total synthesis of natural products and pharmaceutical preparations. Especially in pharmaceutical research and development, (R)-4-Benzyl-2-oxazolidinone not only serves as a key precursor for the synthesis of aromatase inhibitors, but also can be used in studies related to estrogen-dependent breast cancer.

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(R)-4-Benzyl-2-oxazolidinone 화학구조

CAS No. : 102029-44-7

사이즈	재고	수량
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	해외재고보유	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	해외재고보유	Estimated Time of Arrival: December 31
Solid
10 g	해외재고보유	Estimated Time of Arrival: December 31
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	해외재고보유	Estimated Time of Arrival: December 31
100 g	해외재고보유	Estimated Time of Arrival: December 31
250 g	해외재고보유	Estimated Time of Arrival: December 31
500 g	해외재고보유	Estimated Time of Arrival: December 31
1000 g	해외재고보유	Estimated Time of Arrival: December 31
> 100 g	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

Biological Activity
순도&문서
References
고객리뷰

제품 설명

IC₅₀ & Target

Aromatase

In Vitro

4-Benzyl-2-oxazolidinone serves as the core chiral parent nucleus of aromatase inhibitors, and the inhibitory activity of derivatives of (R)-4-Benzyl-2-oxazolidinone is significantly superior to that of (S)-4-Benzyl-2-oxazolidinone^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

177.20

화학식

C₁₀H₁₁NO₂

CAS No.

102029-44-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(OC1)N[C@@H]1CC2=CC=CC=C2

선적

Room temperature in continental US; may vary elsewhere.

보관

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

용액&용해도

In Vitro:

DMSO : 50 mg/mL (282.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.6433 mL	28.2167 mL	56.4334 mL
5 mM	1.1287 mL	5.6433 mL	11.2867 mL
10 mM	0.5643 mL	2.8217 mL	5.6433 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 99.83%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (249 KB) HNMR (132 KB) LCMS (322 KB) GC (211 KB)

Handling Instructions (2659 KB)

References

[1]. Ahmed S, et al. Novel oxazolidinone based compounds as inhibitors of aromatase and the use of the substrate-heme complex approach in the rationalisation of these compounds. Biochem Biophys Res Commun. 2002;294(2):380-383. [Content Brief]

[2]. Heravi M M, e tal. Applications of oxazolidinones as chiral auxiliaries in the asymmetric alkylation reaction applied to total synthesis[J]. RSC advances, 2016, 6(36): 30498-30551.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.6433 mL	28.2167 mL	56.4334 mL	141.0835 mL
	5 mM	1.1287 mL	5.6433 mL	11.2867 mL	28.2167 mL
	10 mM	0.5643 mL	2.8217 mL	5.6433 mL	14.1084 mL
	15 mM	0.3762 mL	1.8811 mL	3.7622 mL	9.4056 mL
	20 mM	0.2822 mL	1.4108 mL	2.8217 mL	7.0542 mL
	25 mM	0.2257 mL	1.1287 mL	2.2573 mL	5.6433 mL
	30 mM	0.1881 mL	0.9406 mL	1.8811 mL	4.7028 mL
	40 mM	0.1411 mL	0.7054 mL	1.4108 mL	3.5271 mL
	50 mM	0.1129 mL	0.5643 mL	1.1287 mL	2.8217 mL
	60 mM	0.0941 mL	0.4703 mL	0.9406 mL	2.3514 mL
	80 mM	0.0705 mL	0.3527 mL	0.7054 mL	1.7635 mL
	100 mM	0.0564 mL	0.2822 mL	0.5643 mL	1.4108 mL