(R)-4-Benzyl-2-oxazolidinone
Based on 1 Customer Validation
(R)-4-Benzyl-2-oxazolidinone is an oxazolidinone-type auxiliary that enables highly stereoselective asymmetric alkylation reactions. (R)-4-Benzyl-2-oxazolidinone is applied in the total synthesis of natural products and pharmaceutical preparations. Especially in pharmaceutical research and development, (R)-4-Benzyl-2-oxazolidinone not only serves as a key precursor for the synthesis of aromatase inhibitors, but also can be used in studies related to estrogen-dependent breast cancer.
For research use only. We do not sell to patients.
- Purity : 99.88%
- CAS No.: 102029-44-7
- Formula: C10H11NO2
- Molecular Weight:177.20
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
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HY-41882
(S)-4-Benzyl-2-oxazolidoneBiochemical Reagent -
HY-W002062
(S)-4-Isopropyl-2-oxazolidinoneBiochemical Reagent -
HY-W019727
(S)-4-Phenyloxazolidin-2-oneBiochemical Reagent -
HY-W002320
(R)-4-Isopropyloxazolidin-2-oneBiochemical Reagent -
HY-40229
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QuinineAlkaloid -
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(R)-(+)-tert-ButylsulfinamideChiral Reagent -
HY-Y1069
(S)-Malic acid -
HY-N0130
Shikimic acidMetabolic Intermediate -
HY-N0464
D-(-)-Quinic acidEndogenous Metabolite -
HY-W019727R
(S)-4-Phenyloxazolidin-2-one (Standard)Biochemical Reagent -
HY-N2085
L-PerillaldehydeAntidepressant-like Agent
Biological Activity
Description
IC50 & Target
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Aromatase |
In Vitro
4-Benzyl-2-oxazolidinone serves as the core chiral parent nucleus of aromatase inhibitors, and the inhibitory activity of derivatives of (R)-4-Benzyl-2-oxazolidinone is significantly superior to that of (S)-4-Benzyl-2-oxazolidinone[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 102029-44-7
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Appearance Solid
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Molecular Weight 177.20
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Formula C10H11NO2
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Color White to off-white
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SMILES
O=C(OC1)N[C@@H]1CC2=CC=CC=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 50 mg/mL (282.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Endocrine Diseases
Endocrine diseases often arise from disrupted hormone production, hormone signaling, or target-tissue responsiveness; for diabetes-focused endocrine disease models, insulin signaling regulates glucose uptake, hepatic glucose output, lipid metabolism, and β-cell compensation. Type 2 diabetes develops through interacting defects in insulin resistance, β-cell dysfunction, adipose inflammation, hepatic glucose overproduction, altered incretin signaling, and ectopic lipid metabolism. A major unresolved question is whether endocrine dysfunction is driven primarily by target-tissue insulin resistance, intrinsic β-cell failure, immune/inflammatory stress, or combined multi-organ failure that differs by disease stage.
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 5.6433 mL | 28.2167 mL | 56.4334 mL | 141.0835 mL |
| 5 mM | 1.1287 mL | 5.6433 mL | 11.2867 mL | 28.2167 mL | |
| 10 mM | 0.5643 mL | 2.8217 mL | 5.6433 mL | 14.1084 mL | |
| 15 mM | 0.3762 mL | 1.8811 mL | 3.7622 mL | 9.4056 mL | |
| 20 mM | 0.2822 mL | 1.4108 mL | 2.8217 mL | 7.0542 mL | |
| 25 mM | 0.2257 mL | 1.1287 mL | 2.2573 mL | 5.6433 mL | |
| 30 mM | 0.1881 mL | 0.9406 mL | 1.8811 mL | 4.7028 mL | |
| 40 mM | 0.1411 mL | 0.7054 mL | 1.4108 mL | 3.5271 mL | |
| 50 mM | 0.1129 mL | 0.5643 mL | 1.1287 mL | 2.8217 mL | |
| 60 mM | 0.0941 mL | 0.4703 mL | 0.9406 mL | 2.3514 mL | |
| 80 mM | 0.0705 mL | 0.3527 mL | 0.7054 mL | 1.7635 mL | |
| 100 mM | 0.0564 mL | 0.2822 mL | 0.5643 mL | 1.4108 mL |
(R)-4-Benzyl-2-oxazolidinone Related Classifications
HY-W007664 Related Classifications
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