849024-68-6
849024-68-6
Chemical Structure
UFP-101
- CAS No.: 849024-68-6
- Formula:C82H138N32O21
- Molecular Weight:1908.17
SMILES: [Bn-GGGFTGARKSARKRKNQ-NH2]
Biological Activity: UFP-101 is a potent, selective, and competitive antagonist of the NOP receptor, with a pKi of 10.24. UFP-101 displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 shows antidepressant-like effect[1][2].
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UFP-101 | UFP-101 is a potent, selective, and competitive antagonist of the NOP receptor, with a pKi of 10.24. UFP-101 displays >3000-fold selectivity over δ, μ and κ opioid receptors. UFP-101 shows antidepressant-like effect. | |||||||||||||||||||||
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References
- [1]. Calo G, et al. [Nphe1,Arg14,Lys15]nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor. Br J Pharmacol. 2002;136(2):303-311. [Content Brief]
- [2]. Gavioli EC, et al. Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test. Eur J Neurosci. 2003;17(9):1987-1990. [Content Brief]
Keywords
