54 Results for "

gAd

" in MedChemExpress (MCE) Product Catalog:
Products (54)

54 Results for "gAd" in MCE Product Catalog:

12
12 Publications Verification
Cat. No.: HY-B0161A
CAS No.: 136434-34-9
Synonyms: (S)-Duloxetine hydrochloride; LY-248686 hydrochloride
Target:  

Serotonin Transporter

Research Areas:  

Neurological Disease Cancer

Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) is a serotonin-norepinephrine reuptake inhibitor (SNRI) with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .
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12
12 Publications Verification
Cat. No.: HY-B0161
CAS No.: 116539-59-4
Synonyms: LY248686
Target:  

Serotonin Transporter

Research Areas:  

Neurological Disease Cancer

Duloxetine is a serotonin-norepinephrine reuptake inhibitor with a Ki of 4.6 nM, used for treatment of major depressive disorder and generalized anxiety disorder (GAD) .
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5
5 Cited Publications
Cat. No.: HY-N0067
CAS No.: 56-12-2
Synonyms: 4-Aminobutyric acid
γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system .
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1
1 Cited Publications
Cat. No.: HY-Y0367
CAS No.: 110-16-7
Maleic Acid is a Glutamate Decarboxylase (GAD) inhibitor of E. coli and L. monocytogenes.
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1
1 Cited Publications
Cat. No.: HY-B0548
CAS No.: 68-88-2
Target:  

Histamine Receptor

Hydroxyzine, a benzodiazepine antihistamine agent, acts as an orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine has anxiolytic effect and can be used for the research of generalised anxiety disorder .
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1
1 Cited Publications
Cat. No.: HY-B0548A
CAS No.: 2192-20-3
Target:  

Histamine Receptor

Hydroxyzine dihydrochloride, a benzodiazepine antihistamine agent, acts as a orally active histamine H1-receptor and serotonin antagonist. Hydroxyzine dihydrochloride has anxiolytic effect and can be used forthe research of generalised anxiety disorder .
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1
1 Cited Publications
Cat. No.: HY-W012906
CAS No.: 16338-48-0
Synonyms: L-2-Allylglycine
L-Allylglycine (L-2-Allylglycine) is an amino acid derivative. L-Allylglycine is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine exhibits convulsant activity .
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1
1 Cited Publications
Cat. No.: HY-W015595
CAS No.: 195316-72-4
Synonyms: L-2-Allylglycine hydrochloride
L-Allylglycine (L-2-Allylglycine) hydrochloride is an amino acid derivative. L-Allylglycine hydrochloride is an inhibitor for glutamate decarboxylase (GAD) that reduces the GABA biosynthesis in the brain. L-Allylglycine hydrochloride exhibits convulsant activity .
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1
1 Cited Publications
Cat. No.: HY-P75178
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Glutamate decarboxylase 2; gAd-65; gAd2
Species:  
Source:  
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Cat. No.: HY-118901
CAS No.: 315-72-0
Purity:  99.91%
Synonyms: Ensidon; G-33040
Target:  

Sigma Receptor

Research Areas:  

Neurological Disease

Opipramol (Ensidon) is an atypical tricyclic antidepressant (TCA). Opipramol acts primarily as a sigma (σ) receptor agonist and can potently interact with sigma recognition sites with a Ki value of 50 nM. Opipramol can be used for the research of generalized anxiety disorder (GAD) .
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Cat. No.: HY-N0067R
CAS No.: 56-12-2
Synonyms: 4-Aminobutyric acid (Standard)
γ-Aminobutyric acid (Standard) is the analytical standard of γ-Aminobutyric acid. This product is intended for research and analytical applications. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain, binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors. γ-Aminobutyric acid shows calming effect by blocking specific signals of central nervous system .
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Cat. No.: HY-18715
CAS No.: 166734-83-4
Synonyms: (S)-Ornidazole; Levornidazole
Levo-ornidazole ((S)-Ornidazole) is the L-isomer of Ornidazole. Ornidazole (Levo-) increases GAD 65/67 expression and decreases brain Glu/GABA ratio. Ornidazole (Levo-) has a mild sedative effect. Levo-ornidazole can be used in the research of anti-anaerobic and anti-parasitic agents .
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Cat. No.: HY-W012123
CAS No.: 90-50-6
3,4,5-Trimethoxycinnamic acid is a phenylpropanoid isolated from the roots of Polygala tenuifolia WILLD, with anti-stress effect, prolonging the sleeping time in animals . 3,4,5-Trimethoxycinnamic acid increases expression of GAD65 and γ-subunit of GABAA receptor, but shows no effect on the amounts of α-, β-subunits .
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Cat. No.: HY-122487
CAS No.: 1926203-09-9
Purity:  99.71%
Synonyms: BHV-4157
Target:  

mGluR

Research Areas:  

Neurological Disease Cancer

Troriluzole, a third-generation, tripeptide proagent of Riluzole (HY-B0211), is an orally active glutamate modulator. Troriluzole reduces synaptic glutamate level and increases the synaptic glutamate absorption. Troriluzole has the potential for Alzheimer disease and generalized anxiety disorder (GAD) .
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Cat. No.: HY-115685
CAS No.: 1216629-00-3
Purity:  99.86%
Target:  

GABA Receptor

Research Areas:  

Neurological Disease

3-Methyl-GABA is a potent GABA aminotransferase activator. 3-Methyl-GABA can fit the binding pocket of GABAA receptor (GABAaR). 3-Methyl-GABA can activate L-glutamic acid decarboxylase (GAD). 3-Methyl-GABA has anticonvulsant activity .
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Cat. No.: HY-W088011B
CAS No.: 2836-32-0
Synonyms: Sodium hydroxyacetate, 98%
Sodium glycolate, 98% (Sodium hydroxyacetate, 98%) is an orally active, versatile organic salt . Sodium glycolate, 98% acts as an enzyme activity regulator that increases the activities of glycolate oxidase (GAO) and lactate dehydrogenase (LDH), while reducing the activity of glycolate dehydrogenase (GAD). Sodium glycolate, 98% induces oxalate biosynthesis and causes hyperoxaluria in rats. Sodium glycolate, 98% reduces urinary calcium excretion in male albino rats. Sodium glycolate, 98% can be used in studies related to calcium oxalate urolithiasis and hyperoxaluria .
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Cat. No.: HY-112291
CAS No.: 165806-53-1
Purity:  99.90%
Target:  

p38 MAPK Src PKC

Research Areas:  

Inflammation/Immunology

SB 220025 is a reversible, orally active, cell-permeable, ATP-competitive and selective human p38 MAPK inhibitor (IC50 = 60 nM). SB 220025 also inhibits p56 Lck and PKC with IC50 values of 3.5 and 2.89 µM, respectively. SB 220025 inhibits the expression of IL-8 gene in response to globular adiponectin (gAd), reduces inflammatory cytokine production and inhibits angiogenesis. SB 220025 effectively prevents the progression of arthritis in a chronic inflammatory disease model and can be used in the study of inflammation .
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Cat. No.: HY-W023493
CAS No.: 7685-44-1
Synonyms: 2-Aminopent-4-enoic acid
Research Areas:  

Neurological Disease

DL-Allylglycine (2-Aminopent-4-enoic acid) is a glutamate decarboxylase (GAD) inhibitor. DL-Allylglycine significantly increases mouse brain ornithine decarboxylase (ODC) activity and decreases S-adenosyl-L-methionine decarboxylase (SAM-DC) activity. DL-Allylglycine causes a marked decrease in brain GABA concentration. DL-Allylglycine has convulsant activity that can be used in studies to induce epileptic seizures .
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Cat. No.: HY-P2525
CAS No.: 245124-26-9
Target:  

MHC

Research Areas:  

Inflammation/Immunology

GAD65 (206-220) is glutamic acid decarboxylase (GAD) 65-derived peptide, corresponding to residues 180-188. GAD65 is presented to T cells in association with I-Ag7 MHC class II molecules and a major pancreatic antigens targeted by self-reactive T cells in type I diabetes mellitus .
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Cat. No.: HY-P5396A
Research Areas:  

Others

GAD65 (524-543) acetate is a biological active peptide with amino acids 524 to 543 fragment of glutamic acid decarboxylase 65 (GAD65). GAD65 (524-543) acetate is one of the first fragments of the islet antigen to induce proliferative T cell responses in the non-obese diabetic (NOD) mouse model of spontaneous autoimmune diabetes. GAD65 (524-543) acetate is a specific, possibly low affinity, stimulus for the spontaneously arising diabetogenic T cell clone BDC2.5. Immunization with GAD65 (524-543) acetate increases the susceptibility of the NOD mice to type 1 diabetes induced by the adoptive transfer of BDC2.5 T cells .
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