Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
human 20s proteasome
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "human 20s proteasome" in MCE Product Catalog:
1
Target:
Research Areas:
Cat. No.: HY-151195
CAS No.: 2827061-47-0
Target:
Research Areas:
20S Proteasome-IN-4 (Compound 7) is a brain-penetrant, parasite-selective, orally active 20S proteasome inhibitor with an IC50 of 6.3 nM against T. b. brucei 20S proteasome. 20S Proteasome-IN-4 can be used for the research of human African trypanosomiasis (HAT) .
Cat. No.: HY-149514
CAS No.: 2260717-73-3
Target:
Research Areas:
BC-05 is an orally active and potent inhibitor of CD13 and proteasome. BC-05 has an IC50 value of 0.13 μM for human CD13 and an IC50 value of 1.39 μM for the 20S proteasome. BC-05 can be used in multiple myeloma research .
Cat. No.: HY-150590
CAS No.: 2028300-31-2
Target:
Research Areas:
20S Proteasome-IN-2 is a human 20S proteasome inhibitor. 20S Proteasome-IN-2 shows high selectivity to its β5 subunit with the IC50 of 0.18 μM. 20S Proteasome-IN-2 displays anti-proliferative effect in vitro and in vivo, and arrests cell cycle at G2/M .
Cat. No.: HY-113824
CAS No.: 1020853-03-5
Synonyms: Ridaifen-F
Target:
Research Areas:
RID-F (Ridaifen-F), a Tamoxifen (HY-13757A) derivative, is a nonpeptidic proteasome inhibitor. RID-F inhibits human 20S proteasome activity, with IC50s of 0.64, 0.34, and 0.43 μM for CT-L, T-L, and PGPH, respectively .
Cat. No.: HY-183009
Target:
Research Areas:
Pf20S-IN-1 is a selective inhibitor of the 20S proteasome β5 subunit of Plasmodium falciparum. Pf20S-IN-1 exhibits antiparasitic activity against Plasmodium falciparum, with an EC50 of 20.1 nM against the Plasmodium falciparum W2 strain. Pf20S-IN-1 shows weak inhibitory effect on human 20S proteasome, has no obvious toxicity to human foreskin fibroblasts (HFF), and has a selectivity index > 25000. Pf20S-IN-1 can be used in malaria research .
Cat. No.: HY-187442
Target:
TDI6245 is a Aurora kinase A (AURKA) inhibitor with an IC50 value of 21.64 nM against AURKA. TDI6245 also inhibits the β5 subunit of the 20S proteasome from Plasmodium falciparum (Pf 20S), with IC50 values of 0.11 μM, 31.1 μM and 6.8 μM against Pf 20S β5, human constitutive proteasome β5c and human immunoproteasome β5i subunits, respectively. TDI6245 binds to the AURKA pocket and the substrate cleft of Pf 20S β5 via antiparallel β-sheets and hydrogen bonds. TDI6245 inhibits the growth of Plasmodium falciparum. TDI6245 can be used in research related to triple-negative breast cancer and malaria .
Cat. No.: HY-P75988
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PSMA3; proteasome Subunit Alpha 3; proteasome 20s Subunit Alpha 3; Alpha-7; HC8; Testicular Secretory Protein Li 43; Multicatalytic Endopeptidase Complex Subunit C8; proteasome Subunit Alpha Type; proteasome Subunit Alpha Type-3; proteasome Subunit Alpha7
Species:
Human
Source:
E. coli
Cat. No.: HY-183468
CAS No.: 945611-89-2
Target:
Research Areas:
MV152 serves as the inactive control for the proteasome activity probe MV151. It contains a reduced ethyl sulfone group that replaces the vinyl sulfone reactive group of MV151, while retaining the identical fluorescent reporter group and peptide recognition sequence. MV152 does not bind to the active site of the proteasomal catalytic subunit β, does not induce peptide-mediated elevation of 20S proteasome activity, and does not label the proteasomal catalytic subunit β in brain tissue homogenates. MV152 can be used as an inactive negative control in proteasome-related experiments .
Cat. No.: HY-181940
Target:
Research Areas:
Berberine-amide-m-PhBA chloride (Compound 8b) is a selective anti-breast cancer agent. Berberine-amide-m-PhBA chloride may inhibit the proteasome by interacting with the 20S proteasome β5 subunit. Berberine-amide-m-PhBA chloride can be used in the research of breast cancer .
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
