2 Results for "

human CTLA-4 knock-in mouse

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "human CTLA-4 knock-in mouse" in MCE Product Catalog:

Cat. No.: HY-P991961

Target:  

CTLA-4

Research Areas:  

Cancer

REGN4659 is a fully human anti-CTLA-4 monoclonal antibody and IgG1 antibody. REGN4659 binds to the extracellular domain of human and monkey CTLA-4 with high affinity and specificity. REGN4659 blocks CTLA-4 interaction with CD80 and CD86 ligands. REGN4659 significantly suppresses MC38.Ova tumor growth in CTLA-4 knock-in mice .
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Cat. No.: HY-P991960

Research Areas:  

Cancer

JS007 is a humanized IgG1 monoclonal antibody and also a CTLA-4 binder, with a Kd of 0.21 nM for CTLA-4. JS007 blocks the interaction between CTLA-4 and B7-1. JS007 activates T cells, promotes increased IL-2 secretion, and inhibits tumor growth in CTLA-4 knock-in mouse syngeneic tumor models. JS007 is applicable to research related to cancer and advanced solid tumors.
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