5 Results for "

human monocyte-macrophages

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "human monocyte-macrophages" in MCE Product Catalog:

7
7 Cited Publications
Cat. No.: HY-N7038
CAS No.: 9008-97-3
Synonyms: PHA-M
Phytohemagglutinin (PHA-M), the major seed lectin of the common bean, Phaseolus vulgaris, is a T-cell activator. Phytohemagglutinin stimulates human mononuclear leukocytes, inducing the expression of ChAT mRNA and potentiating ACh synthesis. Phytohemagglutinin induces dose- and time-dependent toxicity in THP-1 monocytes/macrophages, alters cellular morphology, causes organelle dysfunction, and increases the expression of NF-κB, COX2, IL-1β .
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1
1 Cited Publications
Cat. No.: HY-106409
CAS No.: 914382-60-8
Purity:  99.65%
Synonyms: CHR-2845
Target:  

HDAC Apoptosis

Research Areas:  

Cancer

Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias .
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Cat. No.: HY-170506
CAS No.: 1282128-68-0
KB-208 is a phagocytosis inhibitor. KB-208 inhibits phagocytosis of antibody-opsonized blood cells. KB-208 ameliorates thrombocytopenia in a mouse model of passive antibody-induced immune thrombocytopenia. KB-208 can be used for the research of immune thrombocytopenia .
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Cat. No.: HY-106409R
CAS No.: 914382-60-8
Synonyms: CHR-2845 (Standard)
Research Areas:  

Cancer

Tefinostat (Standard) is the analytical standard of Tefinostat (HY-106409). This product is intended for research and analytical applications. Tefinostat (CHR-2845) is a monocyte/macrophage targeted histone deacetylase (HDAC) inhibitor. Tefinostat can be cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat can be used for the research of leukaemias .
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Cat. No.: HY-P992379
Synonyms: BAG3-H2L4

Target:  

Bcl-2 Family

Research Areas:  

Cancer

IB001 is a humanized anti-BAG3 antibody that inhibits BAG3, with a KD value of 14.4 nM for human BAG3. IB001 blocks BAG3-dependent monocyte/macrophage activation, interferes with the interaction between BAG3 and IFITM-2, and disrupts tumor microenvironment signaling pathways. IB001 inhibits tumor growth, reduces α-SMA-positive fibroblasts, and blocks BAG3-dependent IL-6 release. IB001 accumulates in a time-dependent manner in pancreatic ductal adenocarcinoma tumors. IB001 can be used for research related to pancreatic ductal adenocarcinoma .
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