hyaluronidase

By Targets:	AMPK (1) Apoptosis (1) Autophagy (1) Bacterial (2) Biochemical Assay Reagents (3) Cholinesterase (ChE) (1) Collagen (1) Endogenous Metabolite (1) ERK (1) Fungal (1) Glycosidase (4) Leukotriene Receptor (1) mTOR (1) NF-κB (2) NO Synthase (1) Parasite (1) Proteolytic Enzyme (1) SOD (1) TGF-β Receptor (1) TNF Receptor (1) Tyrosinase (1)
By Research Areas:	Cancer (5) Endocrinology (1) Infection (3) Inflammation/Immunology (6) Metabolic Disease (4) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-107910

Hyaluronidase, Bovine testes Maximum Cited Publications 16 Publications Verification Hyaluronate 4-glycanohydrolase, Bovine testes; Hyaluronoglucosaminidase, Bovine testes	NF-κB	Inflammation/Immunology Cancer
Hyaluronidase, Bovine testes (Hyaluronate 4-glycanohydrolase; Hyaluronoglucosaminidase) is an endoglycosidase that depolymerizes Hyaluronic acid (HA) (HY-B0633A) by cleavage of glycosidic bonds. Hyaluronidase degrades HA and activates membrane receptors that trigger pathways converging in NF-κB activation. Hyaluronidase is employed in the research of granulomatous foreign body reactions, soft-tissue necrosis caused by vascular compromise and uncomplicated nodules, overcorrection, inflamed nodules or tissue ischemia associated with HA filler injection .

HY-108903

Hyaluronidase (human recombinant) Maximum Cited Publications 16 Publications Verification Vorhyaluronidase alfa; rHuPH 20	Biochemical Assay Reagents Glycosidase	Metabolic Disease
Hyaluronidase (human recombinant) (Vorhyaluronidase alfa; rHuPH 20) is an enzyme that catalyzes the degradation of hyaluronic acid. Hyaluronidase (human recombinant) is used to improve the absorption and dispersal of parenteral fluids, medications, and contrast media .

HY-108903A

Hyaluronidase, Ovine testes 10+ Cited Publications	Glycosidase Biochemical Assay Reagents	Endocrinology
Hyaluronidase, Ovine testes is an endoglycosidase. Hyaluronidase, Ovine testes specifically degrades Hyaluronic acid (HY-B0633A) and Chondroitin sulfate (HY-B2162) by hydrolyzing β-glycosidic bonds in acidic mucopolysaccharides. Hyaluronidase, Ovine testes disperses follicular cells during fertilization by breaking down the hyaluronic acid-rich cumulus. Hyaluronidase, Ovine testes can be used in the study of fertility-related diseases .

HY-N0616

Trifolirhizin	Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB	Infection Metabolic Disease Inflammation/Immunology Cancer
Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC₅₀ value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .

HY-P991212

Berahyaluronidase alfa ALT-B4	Glycosidase	Cancer
Berahyaluronidase alfa (ALT-B4) is a recombinant hyaluronidase engineered from human hyaluronidase PH20. Berahyaluronidase alfa features favorable structural stability and enzymatic activity, and can be used to enhance drug absorption and dispersion in subcutaneous or intradermal administration .

HY-N2589

Isosaponarin	TGF-β Receptor Collagen	Infection Metabolic Disease Inflammation/Immunology Cancer
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects .

HY-124504

Lunularic acid	Endogenous Metabolite	Others
Lunularic acid is a dihydrostilbene compound with anti-hyaluronidase activity (IC₅₀: 0.13 nM). Lunularic acid can be used as an endogenous growth inhibitor in liverworts, replacing the function of abscisic acid in higher plants .

HY-W540661

Hyaluronic acid tetrasaccharide, 98%	Biochemical Assay Reagents	Others
Hyaluronic acid tetrasaccharide, 98% is a naturally occurring polysaccharide found in the extracellular matrix of connective tissues. Hyaluronic acid tetrasaccharide can be used as a substrate for enzyme assays to characterize hyaluronidases and other hyaluronic acid-degrading enzymes.

HY-N15572

1,2,4,6-Tetra-O-galloyl-β-D-glucose	SOD	Inflammation/Immunology
1,2,4,6-Tetra-O-galloyl-β-D-glucose is an antioxidant found in Eucalyptus globulus. 1,2,4,6-Tetra-O-galloyl-β-D-glucose has significant superoxide dismutase (SOD)-like antioxidant activity (EC₅₀: 1.55 μM). 1,2,4,6-Tetra-O-galloyl-β-D-glucose can inhibit tyrosinase (IC₅₀: 0.59 mM) and hyaluronidase (IC₅₀: 0.68 mM). 1,2,4,6-Tetra-O-galloyl-β-D-glucose can be used in food antioxidants, cosmetics anti-melanogenesis and anti-allergy/anti-inflammatory research .

HY-138050

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor	Infection Inflammation/Immunology
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, *hyaluronidase* inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

HY-N16652

Foeniculoside I	Others	Inflammation/Immunology Cancer
Foeniculoside I is a stilbene trimer glycoside compound found in Foeniculum vulgare. Foeniculoside I has strong antioxidant activity and moderate hyaluronidase inhibitory activity. Foeniculoside I can be used for the researches of cancer, inflammation and immunology .

HY-107940

Sutilains	Proteolytic Enzyme	Others
Sutilains is a proteolytic enzyme that dissolves necrotic tissue and hyaluronidase. Sutilains can be used as a topical debriding agent in burns .

HY-108903B

Hyaluronidase, Streptomyces hyalurolyticus	Glycosidase	Metabolic Disease
Hyaluronidase, Streptomyces hyalurolyticus (EC 3.2.1.35) degrades hyaluronan and has been found to be inappropriately regulated during cancer progression. Hyaluronidase randomly cleaves β-N-acetylhexosamine-[1→4] glycosidic bonds in hyaluronic acid, chondroitin, and chondroitin sulfates.

HY-N16715

Monardic acid A	Cholinesterase (ChE)	Neurological Disease
Monardic acid A is a selective inhibitor of AChE, with an IC₅₀ of 53.1 μM against AChE from electric eel. Monardic acid A shows weak inhibitory activity against human erythrocyte AChE (IC₅₀ >100 μM) and has no significant inhibitory effect on BChE. Monardic acid A reduces acetylcholine breakdown by inhibiting AChE activity, and also exhibits inhibitory activity against histamine release and hyaluronidase, thus exerting anti-inflammatory and neurotransmitter regulatory effects. Monardic acid A can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus), and is mainly used in the development of anti-inflammatory drugs and drugs related to neurodegenerative diseases .

Cat. No.	Product Name	Type

HY-W540661

Hyaluronic acid tetrasaccharide, 98%	Biochemical Assay Reagents
Hyaluronic acid tetrasaccharide, 98% is a naturally occurring polysaccharide found in the extracellular matrix of connective tissues. Hyaluronic acid tetrasaccharide can be used as a substrate for enzyme assays to characterize hyaluronidases and other hyaluronic acid-degrading enzymes.

Cat. No.	Product Name	Target	Research Area	Image

HY-P991212

Berahyaluronidase alfa ALT-B4	Glycosidase	Cancer
Berahyaluronidase alfa (ALT-B4) is a recombinant hyaluronidase engineered from human hyaluronidase PH20. Berahyaluronidase alfa features favorable structural stability and enzymatic activity, and can be used to enhance drug absorption and dispersion in subcutaneous or intradermal administration .

HY-P992147

Zinihyaluronidase alfa	Inhibitory Antibodies	Others
Zinihyaluronidase alfa is a hyaluronidase .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0616

Trifolirhizin	Structural Classification Flavonoids Classification of Application Fields Leguminosae Trifolium pratense Linn. Sophora flavescens Aiton Plants Other Flavonoids Inflammation/Immunology Disease Research Fields Source Classification Cancer	Tyrosinase TNF Receptor Bacterial Apoptosis Autophagy AMPK mTOR ERK NF-κB
Trifolirhizin is a pterocarpan flavonoid found in the roots of Sophora flavescens. Trifolirhizin is a tyrosinase inhibitor with an IC₅₀ value of 506.77 μM. Trifolirhizin reduces intracellular melanin production and modulates multiple signaling pathways including NFκB-MAPK, AMPK/mTOR, PI3K/Akt, MAPK-NFATc1 and EGFR-MAPK. Trifolirhizin targets biological molecules including PTK6 and COX-2, inhibits the activities of hyaluronidase, collagenase and elastase, induces apoptosis, autophagy and cell cycle arrest, and suppresses the proliferation, migration and invasion of cancer cells. Trifolirhizin exerts diverse pharmacological effects including anti-inflammatory, anti-asthmatic, bone-protective, renoprotective, antibacterial, antifungal, hepatoprotective, antiplatelet, estrogenic and wound-healing activities. Trifolirhizin can be used to investigate a broad range of malignant, inflammatory, metabolic and infectious disorders .

HY-N2589

Isosaponarin	Flavonoids Vaccaria segetalis (Neck.) Garcke Classification of Application Fields Flavones Other Diseases Phenols Polyphenols Plants Disease Research Fields Caryophyllaceae Source Classification	TGF-β Receptor Collagen
Isosaponarin is a flavone glycoside isolated from wasabi leaves. Isosaponarin is a P4HA2 enzymatic agonist. Isosaponarin increases collagen synthesis via up-regulated TGF-β type II receptor (TβR-II) and prolyl 4-hydroxylase (P4H) proteins production, promoting skin health and wound healing. Isosaponarin-rich plants exhibit strong antimicrobial, antioxidant, anti-hyaluronidase, antiplatelet, anti-atopic dermatitis, and anti-tumor effects .

HY-124504

Lunularic acid	Marchantiaceae Marchantia alpestris Phenols Polyphenols Plants Source Classification	Endogenous Metabolite
Lunularic acid is a dihydrostilbene compound with anti-hyaluronidase activity (IC₅₀: 0.13 nM). Lunularic acid can be used as an endogenous growth inhibitor in liverworts, replacing the function of abscisic acid in higher plants .

HY-N15572

1,2,4,6-Tetra-O-galloyl-β-D-glucose	Phenols Polyphenols Myrtaceae Plants Eucalyptus globulus Labill. Source Classification	SOD
1,2,4,6-Tetra-O-galloyl-β-D-glucose is an antioxidant found in Eucalyptus globulus. 1,2,4,6-Tetra-O-galloyl-β-D-glucose has significant superoxide dismutase (SOD)-like antioxidant activity (EC₅₀: 1.55 μM). 1,2,4,6-Tetra-O-galloyl-β-D-glucose can inhibit tyrosinase (IC₅₀: 0.59 mM) and hyaluronidase (IC₅₀: 0.68 mM). 1,2,4,6-Tetra-O-galloyl-β-D-glucose can be used in food antioxidants, cosmetics anti-melanogenesis and anti-allergy/anti-inflammatory research .

HY-138050

Nyasol (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol	Phenols Polyphenols Hypoxis angustifolia Lam. Plants Source Classification Asparagaceae Juss.	NO Synthase Bacterial Fungal Parasite Leukotriene Receptor
Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, *hyaluronidase* inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells .

HY-N16652

Foeniculoside I	Structural Classification Phenols Polyphenols Umbelliferae Plants Vernonia Schreb. Source Classification	Others
Foeniculoside I is a stilbene trimer glycoside compound found in Foeniculum vulgare. Foeniculoside I has strong antioxidant activity and moderate hyaluronidase inhibitory activity. Foeniculoside I can be used for the researches of cancer, inflammation and immunology .

HY-N16715

Monardic acid A	Structural Classification Lignans Phenylpropanoids Plants Pulmonaria officinalis L. Boraginaceae Source Classification	Cholinesterase (ChE)
Monardic acid A is a selective inhibitor of AChE, with an IC₅₀ of 53.1 μM against AChE from electric eel. Monardic acid A shows weak inhibitory activity against human erythrocyte AChE (IC₅₀ >100 μM) and has no significant inhibitory effect on BChE. Monardic acid A reduces acetylcholine breakdown by inhibiting AChE activity, and also exhibits inhibitory activity against histamine release and hyaluronidase, thus exerting anti-inflammatory and neurotransmitter regulatory effects. Monardic acid A can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus), and is mainly used in the development of anti-inflammatory drugs and drugs related to neurodegenerative diseases .

Species:	Human (3) Mouse (1)
Tag:	His (5)
Source:	HEK293 (4) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P79168

	Hyaluronan Lyase Protein, S. agActiae (His) hyaluronidase; SAG1197	Others	E. coli
	Hyaluronate lyase is a polysaccharide-derived carboxylase, also known as a diffusion factor or mucin. This enzyme can cleave hyaluronic acid salts at the β-D-GalNAc-(1→4)-β-D-GlcA glycosidic bond site through a β-elimination reaction, and the resulting unsaturated disaccharide can initiate downstream reaction pathways. Hyaluronan Lyase Protein, S. agActiae (His) is a recombinant hyaluronic acid lyase protein with the His tag.

HY-P79066

	Hyaluronidase 2/HYAL2 Protein, Human (HEK293, His) hyaluronidase 2; LUCA2; LuCa-2; Hyaluronoglucosaminidase 2; Lung Carcinoma Protein 2; Lysosomal hyaluronidase; Hyaluronoglucosaminidase-2	Human	HEK293
	Hyaluronidase 2 (HYAL2) protein participates in the hydrolysis of high molecular weight hyaluronic acid, generating intermediate-sized products. Despite low activity, HYAL2 contributes to extracellular matrix dynamics through hyaluronic acid breakdown. Furthermore, it associates with and negatively regulates MST1R, suggesting a potential role in cellular processes mediated by MST1R. Hyaluronidase 2/HYAL2 Protein, Human (HEK293, His) is the recombinant human-derived Hyaluronidase 2/HYAL2 protein, expressed by HEK293 , with C-His labeled tag.

HY-P703763

	Hyaluronidase 2/HYAL2 Protein, Mouse (HEK293, His) hyaluronidase-2; Hyaluronoglucosaminidase-2; Hyal2; Hyal-2	Mouse	HEK293
	Hyaluronidase 2/HYAL2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived Hyaluronidase 2/HYAL2 protein, expressed by HEK293, with C-His tag.

HY-P70411

	Hyaluronidase-1/HYAL1 Protein, Human (HEK293, His, solution) 1 Publications Verification rHuhyaluronidase-1/HYAL1, His; hyaluronidase-1; Hyal-1; Hyaluronoglucosaminidase-1; Lung Carcinoma Protein 1; LuCa-1; HYAL1; LUCA1	Human	HEK293
	Hyaluronidase-1/HYAL1 Protein is implicated in tumor progression, suggesting its role in cancer advancement. It also inhibits TGFB1-enhanced cell growth, revealing its regulatory function. HYAL1's dual impact on promoting tumor progression and inhibiting specific cellular processes underscores its complex involvement in cellular behavior and potential significance in tumorigenesis. Hyaluronidase-1/HYAL1 Protein, Human (HEK293, His, solution) is the recombinant human-derived Hyaluronidase-1/HYAL1 protein, expressed by HEK293 , with C-6*His labeled tag.

HY-P70411A

	Hyaluronidase-1/HYAL1 Protein, Human (HEK293, C-His) rHuhyaluronidase-1/HYAL1, His; hyaluronidase-1; Hyal-1; Hyaluronoglucosaminidase-1; Lung Carcinoma Protein 1; LuCa-1; HYAL1; LUCA1	Human	HEK293
	Hyaluronidase-1/HYAL1 Protein is implicated in tumor progression, suggesting its role in cancer advancement. It also inhibits TGFB1-enhanced cell growth, revealing its regulatory function. HYAL1's dual impact on promoting tumor progression and inhibiting specific cellular processes underscores its complex involvement in cellular behavior and potential significance in tumorigenesis. Hyaluronidase-1/HYAL1 Protein, Human (HEK293, C-His) is the recombinant human-derived Hyaluronidase-1/HYAL1, expressed by HEK293, with C-6His labeled tag. The total length of Hyaluronidase-1/HYAL1 Protein, Human (HEK293, C-His) is 414 a.a.*.

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HY-P86254

	SPAM1 Antibody (YA5946) SPAM1; HYAL3; PH20; hyaluronidase PH-20 ; Hyal-PH20; Hyaluronoglucosaminidase PH-20; Sperm adhesion molecule 1; Sperm surface protein PH-20;	WB, IHC-P	Human
	SPAM1 Antibody (YA5946) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SPAM1.

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