96895-25-9
96895-25-9
Chemical Structure
Nyasol
Synonym(s): (-)-Nyasol; (Z)-Hinokiresinol; cis-Hinokiresinol
- CAS No.: 96895-25-9
- Formula:C17H16O2
- Molecular Weight:252.31
IUPAC Name: (R,Z)-4,4'-(penta-1,4-diene-1,3-diyl)diphenol
InChIKey: VEAUNWQYYMXIRB-JHAQOBCDSA-N
SMILES: C=C[C@@H](C1=CC=C(O)C=C1)/C=C\C2=CC=C(O)C=C2
Biological Activity: Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells[1][2].
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Nyasol | Nyasol ((-)-Nyasol) is an active compound that has antifungal, antibacterial, antileishmanial, hyaluronidase inhibition activities. Nyasol inhibits LTB4 binding to human neutrophils. Nyasol suppresses neuroinflammatory response through the inhibition of I-κB degradation in LPS (HY-D1056)-stimulated BV-2 microglial cells. | |||||||||||||||||||||
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References
- [1]. Lim H, et al. (-)-Nyasol (cis-hinokiresinol), a norneolignan from the rhizomes of Anemarrhena asphodeloides, is a broad spectrum inhibitor of eicosanoid and nitric oxide production. Arch Pharm Res. 2009 Nov;32(11):1509-14. [Content Brief]
- [2]. Iida Y, et al. In vitro synergism between nyasol, an active compound isolated from Anemarrhena asphodeloides, and azole agents against Candida albicans. Planta Med. 2000 Jun;66(5):435-8. [Content Brief]
