6 Results for "

immunosuppressed mice

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "immunosuppressed mice" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-N6727
CAS No.: 67-99-2
Synonyms: Aspergillin
Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis . Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells . Gliotoxin is a potent NOTCH2 transactivation inhibitor, can effectively induce apoptosis of chronic lymphocytic leukemia (CLL) cells .
loading...
    loading...
Cat. No.: HY-171034
CAS No.: 1604678-82-1
PQA-18 is a unique PAK2 inhibitor (IC50: 10 nM). PQA-18 has immunosuppressing effects. PQA-18 suppresses IL2, IL4, IL6, and TNFα. PQA-18 inhibits the population of a subset of regulatory T cells and the immunoglobulin (Ig) production against T cell-dependent antigens as well as alleviates dermatitis in mice .
loading...
    loading...
Cat. No.: HY-P11031
Target:  

Fungal

Research Areas:  

Infection

CotH3 peptide is a functional peptide unique to Mucorales that binds to the host GRP78 receptor and allows them to invade endothelial cells. CotH3 peptide–targeted monoclonal antibodies protect immunosuppressed mice from mucormycosis caused by R. delemar and other Mucorales. CotH3 peptide also synergizes with antifungal drugs to protect mice with diabetic ketoacidosis (DKA) from R. delemar infection .
loading...
    loading...
Cat. No.: HY-163482
CAS No.: 3023709-98-7
Target:  

Parasite

Research Areas:  

Infection

ELQ-596 is a quinolone derivative, that exhibits antimicrobial activity against several protozoan parasites, including the intraerythrocytic parasites Plasmodium and Babesia. ELQ-596 attenuates babesiosis in immunosuppressed mice .
loading...
    loading...
Cat. No.: HY-163484
CAS No.: 3023710-00-8
Target:  

Parasite

Research Areas:  

Infection

ELQ-650 is a quinolone derivative, that exhibits antimicrobial activity against several protozoan parasites, including the intraerythrocytic parasites Plasmodium and Babesia. ELQ-650 attenuates babesiosis in immunosuppressed mice .
loading...
    loading...
Cat. No.: HY-19377
CAS No.: 229153-17-7
Target:  

Fungal Cytochrome P450

Research Areas:  

Infection

SS-750 is an orally active Triazole derivative and antifungal agent. SS-750 binds to fungal cytochrome P450. SS-750 shows antifungal activities against Candida species and C. neoformans strains tested. SS750 shows MIC90 values of 0.25, 1, and 2 μg/mL against Candida parapsilosis, C. krusei, and C. glabrata, respectively. SS-750 improves systemic and pulmonary candidiasis caused by C. albicans .
loading...
    loading...