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in vitro study

" in MedChemExpress (MCE) Product Catalog:

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259

Inhibitors & Agonists

Screening Libraries

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Targets Recommended: Dan family AIM2 CD44 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-139611

Navlimetostat 3 Publications Verification MRTX-1719; BMS-986504	Histone Methyltransferase	Cancer
Navlimetostat is a potent, orally active, selective PRMT5-MTA complex inhibitor, with IC₅₀ of 3.6 and 20.5 nM for PRMT5-MTA and PRMT5. Navlimetostat binds to the PRMT5-MTA complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study .

HY-113071A

Mevalonic acid lithium salt Maximum Cited Publications 10 Publications Verification MVA lithium salt	Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure .

HY-D1451

PKH 26 35+ Cited Publications	Fluorescent Dye	Others
PKH 26 is a red fluorescent dye, PKH 26 can stably bind to the lipid region of cell membrane and emit red fluorescence (Ex/Em=551/567 nm), which is mainly used for in vitro cell labeling, in vitro cell proliferation studies and in vivo and in vitro cell tracing studies .

HY-125856

Milvexian 2 Publications Verification BMS-986177; JNJ-70033093	Factor Xa	Cardiovascular Disease
Milvexian is an orally bioavailable, small-molecule, reversible, direct antagonists of factor Xia, with the K_i of 0.11, 0.38, 0.64, 490, 350 nM for human, rabbit, dog, rat, mouse, respectively. Milvexian shows anti-thrombosis activity in vitro and in vivo, and can be used for thrombus study .

HY-W008491

TK-112690	Phosphorylase	Inflammation/Immunology Cancer
TK-112690 is a UPP1 inhibitor. TK-112690 inhibits murine small intestinal uridine phosphorylase (UPase) with an IC₅₀ of 12.5 μM and human small intestinal UPase with an IC₅₀ of 20.0 μM in vitro. TK-112690 increases plasma uridine concentration in mice. TK-112690 can be used for the study of cancer and pulmonary fibrosis .

HY-112579

Ceftobiprole 3 Publications Verification Ro 63-9141; BAL 9141	Bacterial Antibiotic	Infection Inflammation/Immunology
Ceftobiprole (Ro 63-9141) is a broad-spectrum cephalosporin with high levels of in vitro activity against methicillin- (MRSA) and vancomycin-resistant staphylococci (VRSA) and penicillin-resistant streptococci with a MIC₉₀ value of 2 μg/mL for MRSA. Ceftobiprole also inhibits gram-positive and gram-negative pathogens. Ceftobiprole can be used for the study of hospital-acquired pneumonia (excluding ventilator-associated pneumonia) and community-acquired pneumonia .

HY-148530

YX-2-107	PROTACs CDK	Cancer
YX-2-107 is a PROTAC (IC₅₀= 4.4 nM) that selectively degrades CDK6. YX-2-107 effectively inhibits RB phosphorylation and FOXM1 expression in vitro and inhibits the development of Ph ⁺ ALL in rats. YX-2-107 can be used in the study of Ph chromosome-positive (Ph ⁺) acute lymphoblastic leukemia (ALL) .

HY-B1050

Gemifloxacin mesylate SB-265805S; LB-20304a	Bacterial Antibiotic DNA/RNA Synthesis Topoisomerase	Infection
Gemifloxacin mesylate (SB-265805S; LB-20304a) is an orally active broad-spectrum quinolone antibacterial antibiotic. Gemifloxacin mesylate inhibits DNA synthesis by inhibiting DNA gyrase and Topoisomerase IV activities. Gemifloxacin mesylate has potent antibacterial activities against gram-positive bacteria in vitro efficacy study, particularly Streptococci and Staphylococci. Gemifloxacin mesylate has been used in the research of respiratory tract infections .

HY-DY1011

PKH 26 (solution)	Fluorescent Dye	Others
PKH 26 (solution) is a red fluorescent dye, PKH 26 can stably bind to the lipid region of cell membrane and emit red fluorescence (Ex/Em=551/567 nm) , which is mainly used for in vitro cell labeling, in vitro cell proliferation studies and in vivo and in vitro cell tracing studies . Solvent and concentration: DMSO: 5 mM

HY-B0395C

Sitafloxacin hydrate 5+ Cited Publications DU6859a hydrate	Bacterial Antibiotic	Infection
Sitafloxacin (DU6859a) hydrate is an orally active fluoroquinolone antibiotic (antibiotic) with in vitro activity against a wide range of Gram-positive and -negative bacteria, including anaerobic bacteria, as well as atypical pathogens. Sitafloxacin is used in the study of respiratory tract infections and urinary tract infections .

HY-113071

Mevalonic acid MVA	Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure .

HY-156038

(S)-p-SCN-Bn-DOTA	Biochemical Assay Reagents	Others
(S)-p-SCN-Bn-DOTA is a bifunctional chelator (BFC), a macrocyclic DOTA derivative for tumor pretargeting. (S)-p-SCN-Bn-DOTA can be used for the conjugation of peptides and radionuclides, such as as a linker for In-111 labeled radioimmunoconjugates (RICs) for single photon emission tomography (SPECT) and in vitro biodistribution studies .

HY-120789

PF-06648671	γ-secretase	Neurological Disease
PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimer’s disease .

HY-105634A

Nomegestrol acetate	Progesterone Receptor	Endocrinology Cancer
Nomegestrol acetate is an orally active, highly selective progestogen and a progesterone receptor complete agonist. Nomegestrol acetate inhibits ovulation. Nomegestrol acetate is also effective in inhibiting the proliferation of human endometrial cancer RL95-2 cells in vitro and in vivo. Nomegestrol acetate can be used in cancer (especially endometrial cancer) and contraceptive studies .

HY-N6703

ar-Turmerone (+)-ar-Turmerone	Apoptosis	Neurological Disease Inflammation/Immunology Cancer
ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .

HY-153215

MEL24	Ligands for E3 Ligase	Cancer
MEL24 is an Mdm2 E3 ligase inhibitor that reduces cell survival and increases sensitivity to DNA damaging agents in a p53-dependent manner for in vitro antitumor studies .

HY-B1148

Furaltadone hydrochloride 1 Publications Verification Altafur hydrochloride	Bacterial	Infection Inflammation/Immunology
Furaltadone hydrochloride is an orally active antibacterial agent that can be used for the study of intestinal Salmonella infections. Furaltadone has in vitro inhibitory effects on Staphylococcus. In addition, Furaltadone shows inhibitory effects on allergic reactions .

HY-P11117

TAT-EE3	TRP Channel iGluR Calcium Channel	Neurological Disease
TAT-EE3 is a neuroprotective peptide which can uncouple TRPM2-NMDARs interaction. TAT-EE3 inhibits TRPM2-induced enhancement of NMDAR surface expression and current amplitude.TAT-EE3 protects neurons against ischemic injury in vitro and in vivo. TAT-EE3can be used for the study of ischemic stroke .

HY-B0488

Clorsulon 1 Publications Verification L631529; MK401	Parasite	Infection
Clorsulon (L631529; MK401) is an orally active flukicidal agent. Clorsulon inhibits glycolysis, the primary energy production pathway in flukes. Clorsulon is also a competitive inhibitor of 3-phosphoglycolate and ATP, inhibiting glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon can be used in studies of liver fluke (Fasciola hepatica and Fasciola gigantica) infection in calves and sheep .

HY-171499

Cenersen EL625	MDM-2/p53	Cancer
Cenersen (EL625) is an oligonucleotide targeting TP53. Cenersen can eliminate the activity of TP53 gain-of-function mutants and increase the sensitivity of lymphoma cells to cytotoxic chemotherapy in vitro. Cenersen can be used for the study of chronic lymphocytic leukemia (CLL) .

HY-139611C

Navlimetostat hydrochloride 3 Publications Verification MRTX-1719 hydrochloride; BMS-986504 hydrochloride	Histone Methyltransferase	Cancer
Navlimetostat hydrochloride is a potent, orally active, selective PRMT5-MTA complex inhibitor, with IC₅₀s of 3.6 and 20.5 nM for PRMT5-MTA and PRMT5. Navlimetostat hydrochloride binds to the PRMT5-MTA complex, with KD value of 0.14 pM. Navlimetostat shows antineoplastic activity in vitro and in vivo, and can be used for cancer study .

HY-P3397A

JV-1-36 acetate	GHSR	Cancer
JV-1-36 acetate is a growth hormone-releasing hormone (GHRH) antagonist. JV-1-36 acetate inhibits the production of reactive oxygen species in A549 lung cancer cells. JV-1-36 can be used to study the effect of GHRH antagonists in vitro .

HY-112865

Octocog alfa ADVATE; BAY 81-8973; Kovaltry	Factor VIII	Cardiovascular Disease
Octocog alfa (ADVATE; BAY 81-8973; Kovaltry) is a standard half-length recombinant coagulation factor FVIII replacement therapy that also functions as a thrombin generation modulator. Octocog alfa regulates thrombin generation-related parameters in vitro and is used in studies related to severe hemophilia A .

HY-169245

CDK-TCIP2	CDK BCL6	Cancer
DK-TCIP2, linking inhibitor of CDK9 SNS-032 (HY-10008) with ligands of BCL6 BI-3812 (HY-111381), is a anticancer agent. DK-TCIP2 shows anticancer activity in vivo and in vitro and can be used for study of lymphoma cancer .

HY-105064

Zoniporide 2 Publications Verification CP-597396	Na+/H+ Exchanger (NHE)	Cardiovascular Disease
Zoniporide (CP-597396) is a potent and selective NHE-1 inhibitor with cardioprotective activity. Zoniporide inhibits ²²Na ⁺ uptake by human NHE-1-expressing fibroblasts in a concentration-dependent manner (IC₅₀=14 nM). Zoniporide inhibits platelet swelling in vitro with an IC₅₀ of 0.059 μM. Zoniporide can be used in the study of cardiovascular disease .

HY-B1202

Alrestatin 1 Publications Verification AY-22284	Aldose Reductase	Metabolic Disease
Alrestatin (AY-22284) is an aldose reductase inhibitor. Alrestatin reduces fructose levels in the uterine fluid of mice. Alrestatin interferes with sperm capacitation and impairs fertilization function in mice. Alrestatin decreases basal and tyramine-induced norepinephrine release in rat pancreatic specimens in vitro. Alrestatin enhances glucose- and arginine-stimulated insulin secretion in vivo. Alrestatin can be used in studies related to diabetes and reproductive diseases .

HY-148947

Cy5 Phosphoramidite	Fluorescent Dye Phosphoramidites	Others
Cy5 Phosphoramidite is a fluorescent labeling reagent . Cy5 Phosphoramidite serves as a fluorescent tag for 3' terminal labeling of single-stranded DNA, enabling fluorescence-based nucleic acid detection, monitoring, quantification, and in vitro study .

HY-117292

DAO-IN-2 1 Publications Verification	Amino Acid Oxidase	Neurological Disease
DAO-IN-2 is a d-amino acid oxidase (DAO) inhibitor (h-DAO IC₅₀ = 245 nM). DAO-IN-2 is a moderate inhibitor of DAAO in vitro and in vivo. DAO-IN-2 can be used to study DAAO-related psychiatric disorders .

HY-101839

ML381 VU0488130	mAChR	Neurological Disease
ML381 (VU0488130) is a highly selective, central nervous system penetrant mAChR M5 orthogonal antagonist (IC₅₀ = 450 nM; Ki = 340 nM). ML381 is unstable in rat plasma and can be mainly used as a molecular probe for in vitro and electrophysiological studies .

HY-118143

AG-1801	Endogenous Metabolite	Others
AG-1801, a nitrobenzopyridine derivative, is a tyrosine phosphorylation inhibitor. AG-1801 can induce the disintegration of the microtubule network in living cells, and does not inhibit microtubule polymerization in vitro. AG-1801 can be used for the study of microtubule-related signaling pathways .

HY-P10841

CyPep-1	Amino Acid Derivatives	Cancer
CyPep-1 is a novel cationic lytic peptide with antitumor activity. CyPep-1 is highly cytotoxic by interacting with the negatively charged cell membrane of cancer cells. CyPep-1 has strong cytolytic activity on cancer cells both in vivo and in vitro, and can be used in the study of solid tumors .

HY-116211

Amfonelic acid Win-25978	Biochemical Assay Reagents	Neurological Disease
Amfonelic acid (WIN-25978) is a highly selective dopamine reuptake inhibitor. Amfonelic acid interferes with the in vitro neuronal uptake of norepinephrine in the iris of rats, but does not alter the concentrations of norepinephrine or dopamine in the whole mouse brain. Amfonelic acid can be used as a pharmacological tool to study the brain reward system, dopamine pathway and dopamine transporter .

HY-174366

JMC14	c-Fms PI3K	Cancer
JMC14 is a selective and orally active PI3Kδ and CSF1R inhibitor with IC₅₀ values of 12 nM and 143 nM, respectively. JMC14 preferentially inhibits PI3Kδ-mediated signaling at the cellular level. JMC14 demonstrates potent antitumor activity against B-cell lymphomas and triple-negative breast cancer (TNBC) in both in vitro and vivo studies. JMC14 can be used for the study of antitumor immunity .

HY-156168

M190S	Caspase	Cancer
M109S is a novel small molecule protecting cells from mitochondria-dependent apoptosis both in vitro and in vivo. M109S has the potential to become a research tool for studying cell death mechanisms and to develop therapeutics targeting mitochondria-dependent cell death pathway. M109S has orally bioactivity with excellent brain permeability .

HY-B1462S

Chlorzoxazone-d3	Cytochrome P450	Inflammation/Immunology
Chlorzoxazone-d₃ is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans.

HY-116269

AZA197	Ras Apoptosis PAK ERK	Cancer
AZA197 is a selective small molecule inhibitor of Cdc42.AZA197 suppresses colon cancer cell proliferation, cell migration, invasion and increases apoptosis by down-regulating the PAK1 and ERK signaling pathways in vitro. AZA197 reduces tumor growth and significantly increases mouse survival in SW620 tumor xenografts. AZA197 can be used for the study of colon cancer .

HY-W008629

(E, E)-Farnesyl bromide	Biochemical Assay Reagents	Others
(E,E)-Farnesyl bromine is a synthetic substrate that is used to study the enzyme guanine nucleotide-binding protein (G protein) in vitro.

HY-17517

Tiadinil	Fungal Biochemical Assay Reagents	Infection
Tiadinil is a systemic acquired resistance (SAR) inducer, plant elicitor and antifungal agent. Tiadinil promotes the production of herbivore-induced plant volatiles in Camellia sinensis (tea plant). Tiadinil inhibits mycelial growth, spore germination and germ tube elongation of Stagonosporopsis citrulli in vitro. Tiadinil can be used in studies related to vine blight .

HY-162783

AZ-PRMT5i-1	Histone Methyltransferase	Cancer
AZ-PRMT5i-1 (Compound 28) is an effective and orally active MTAP-selective PRMT5 inhibitor. AZ-PRMT5i-1 also demonstrates MTA cooperativity and exhibits both in vitro and in vivo antitumor activities, and can be used to study MTAP-deficient cancers .

HY-B0395CR

Sitafloxacin hydrate (Standard) DU6859a hydrate (Standard)	Bacterial Antibiotic Reference Standards	Infection
Sitafloxacin (hydrate) (Standard) is the analytical standard of Sitafloxacin (hydrate). This product is intended for research and analytical applications. Sitafloxacin (DU6859a) hydrate is an orally active fluoroquinolone antibiotic (antibiotic) with in vitro activity against a wide range of Gram-positive and -negative bacteria, including anaerobic bacteria, as well as atypical pathogens. Sitafloxacin is used in the study of respiratory tract infections and urinary tract infections .

HY-P4126

Suc-Ala-Ala-Pro-Val-AMC	Elastase	Others
Suc-Ala-Ala-Pro-Val-AMC is a fluorescent substrate for elastase. Suc-Ala-Ala-Pro-Val-AMC can be hydrolyzed by these elastases to release the fluorescent substance 7-amino-4-methylcoumarin. Suc-Ala-Ala-Pro-Val-AMC is used for in vitro elastase activity assays and can also be applied in studies related to chronic wounds .

HY-178920

α-Synuclein-IN-17	α-synuclein	Neurological Disease
α-Synuclein-IN-17 (Compound 10) is an α-Synuclein inhibitor, with an IC₅₀ value of 9 μM. α-Synuclein-IN-17 exhibits potent inhibitory activity against both in-vitro assembled asyn fibrils and LBD brain tissue-amplified asyn fibrils. α-Synuclein-IN-17 can be used for the study of Parkinson's disease (PD) and Lewy Body Disease (LBD) .

HY-155241

α-Amylase/α-Glucosidase-IN-4	Glycosidase Amylases	Metabolic Disease
α-Amylase/α-Glucosidase-IN-4 (compound 5) is a dual inhibitor of α-glucosidase (Glucosidase) and α-amylase (Amylases) with IC₅₀s of 0.15 μM and 1.10 μM, respectively. α-Amylase/α-Glucosidase-IN-4 has potential antidiabetic activity .

HY-107584

BYK 191023 dihydrochloride	NO Synthase	Metabolic Disease
BYK 191023 is a highly selective inducible nitric-oxide synthase (iNOS) inhibitor. BYK 191023 interacts with the catalytic center of the enzyme. BYK 191023 can be used to study the in vivo and in vitro effects mediated by iNOS .

HY-155715

G43	Glucosylceramide Synthase (GCS) Bacterial	Infection
G43 is a potent, selective glucosyltransferase inhibitor, with the K_d of 3.7μM and 46.9 nM for GtfB and GtfC, respectively. G43 has antibacterial to S. mutans in vitro and in vivo, and can be used for dental caries study .

HY-177921

PL53	Liposome	Others
PL53 is a kind of cycloalkylamine lipid nanoparticles. PL53 exhibits outstanding transfection efficiency both in vitro and in vivo, especially showing strong protein expression ability and potential tissue targeting after intramuscular injection. PL53 can be used for the study of nucleic acid delivery .

HY-P3397

JV-1-36	GHSR	Cancer
JV-1-36 is a growth hormone-releasing hormone (GHRH) antagonist. JV-1-36 inhibits the production of reactive oxygen species in A549 lung cancer cells. JV-1-36 can be used to study the effect of GHRH antagonists in vitro .

HY-124952

iKIX1	Fungal	Infection
iKIX1 is an antifungal agent and resensitizes drug-resistant C. glabrata to azole antifungals in vitro. iKIX1 inhibits the interaction between the KIX domain of the mediator subunit CgGal11A and the activation domain of CgPdr1, the IC₅₀ and K_i values are 190.2 μM and 18 μM, respectively. iKIX1 is used for the study of multidrug resistance and C. glabrata infection .

HY-P10889

CNI103	Phosphatase	Inflammation/Immunology
CNI103 is a highly potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. CNI103 selectively blocks the interaction between calcineurin and NFATc3 (K_D=16 nM), thereby preventing NFATc3 activation in vitro and in vivo. CNI103 can be used to study acute respiratory distress syndrome (ARDS) and other inflammatory diseases .

HY-113071C

(S)-Mevalonic acid (S)-MVA	Endogenous Metabolite	Cardiovascular Disease Neurological Disease Metabolic Disease
(S)-Mevalonic acid is the isomer of Mevalonic acid (HY-113071). Mevalonic acid ((S)-DCIT) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure .

Cat. No.	Product Name

HY-L056

Terpenoids Library

768 compounds

Terpenoids, also known as isoprenoids, are the most numerous and structurally diverse natural products found in many plants. Terpenoids are divided into monoterpenes, sesquiterpenes, diterpenes, sesterpenes, and triterpenes depending on its carbon units. Several studies, in vitro, preclinical, and clinical have confirmed that this class of compounds displays a wide array of very important pharmacological properties in the fight against cancer, malaria, inflammation, and a variety of infectious diseases. Naturally occurring terpenoids provide new opportunities to discover new drugs with minimum side effects.

MCE designs a unique collection of 768 terpenoid compounds that all come from natural products. MCE Terpenoids Library is a useful tool for drug discovery that can be used for high throughput screening (HTS) and high content screening (HCS).

Cat. No.	Product Name	Type

HY-D1451

PKH 26 35+ Cited Publications	Fluorescent Dye
PKH 26 is a red fluorescent dye, PKH 26 can stably bind to the lipid region of cell membrane and emit red fluorescence (Ex/Em=551/567 nm), which is mainly used for in vitro cell labeling, in vitro cell proliferation studies and in vivo and in vitro cell tracing studies .

HY-DY1011

PKH 26 (solution)	Fluorescent Dye
PKH 26 (solution) is a red fluorescent dye, PKH 26 can stably bind to the lipid region of cell membrane and emit red fluorescence (Ex/Em=551/567 nm) , which is mainly used for in vitro cell labeling, in vitro cell proliferation studies and in vivo and in vitro cell tracing studies . Solvent and concentration: DMSO: 5 mM

HY-15001G

Stemregenin 1

SR1

Fluorescent Dye

Stemregenin 1 (SR1) (GMP) is a GMP-grade Stemregenin 1 (HY-15001). GMP-grade small molecules can be used as adjuvants in cell therapy. Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with an IC₅₀ of 127 nM. Stemregenin 1 (GMP) can competitively bind to AhR and inhibit its nuclear translocation, inhibiting osteoclastogenesis and promoting hematopoietic progenitor cell expansion by blocking the AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway. Stemregenin 1 (GMP) can be used for the study of osteoporosis, in vitro expansion of hematopoietic stem cells, and the study of the mechanism of bone metabolic diseases .

HY-16658BG

Z-VAD-FMK

Fluorescent Dye

Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

HY-D3208

oLOX

Fluorescent Dye

oLOX is a fluorescent activity reporter. oLOX can be activated by lysyl oxidase family (LOXF) enzymes, which in turn releases a luciferin fluorescent product that reports LOXF enzyme activity. After oLOX is activated in in vitro fibrotic lung tissues, the fluorescence intensity increases, enabling real-time detection of fibrotic activity. oLOX can be used in studies related to pulmonary fibrosis .

HY-D3168

PCL-2

Fluorescent Dye

PCL-2 is a reactive oxygen species-responsive fluorescent probe that shows almost no response to biologically relevant reactive oxygen species other than hydrogen peroxide. PCL-2 reacts with hydrogen peroxide to release 6-hydroxy-2-cyanobenzothiazole. PCL-2 can be used for chemoselective imaging of hydrogen peroxide in in vitro models and acute inflammation mouse models. PCL-2 is applicable to studies related to acute inflammation .

HY-D3186

HMRef-βGal

Fluorescent Dye

HMRef-βGal is a fluorescent probe and a substrate responsive to β-galactosidase (β-galactosidase) (Ex/Em=498 nm/505-600 nm). After being cleaved by β-galactosidase, HMRef-βGal triggers significant fluorescence enhancement via intramolecular spirocyclic function regulation. HMRef-βGal generates bright fluorescence in cancer cells with elevated β-galactosidase activity, enabling visualization of tiny peritoneal metastases in mouse models. HMRef-βGal exhibits low in vitro cytotoxicity and low acute in vivo toxicity in mice. HMRef-βGal can be used for preclinical fluorescence-guided diagnosis and cytoreductive surgery of peritoneal metastases, including compatibility with real-time naked-eye detection and endoscopic imaging, as well as for studies related to peritoneal metastases of ovarian cancer .

Cat. No.	Product Name	Type

HY-Y1147

Diethyl maleate

1 Publications Verification

Maleic acid diethyl ester

Biochemical Assay Reagents

Diethyl maleate (DEM) is an orally available, effective glutathione (GSH) depletor that crosses the blood-brain barrier. Diethyl maleate covalently binds irreversibly to GSH via glutathione S-transferase with an in vitro IC50 of 0.1-0.5 mM. Diethyl maleate selectively depletes GSH in liver, lung, and brain tissues, exacerbating oxidative stress and enhancing hyperbaric oxygen toxicity. Diethyl maleate promotes precursor amino acid uptake and in turn promotes GSH synthesis by upregulating the activity of the cystine-glutamate transporter X_{O ^-}. Diethyl maleate can be used to study redox homeostasis and GSH protection mechanisms in oxidative stress-related diseases such as hyperbaric oxygen injury and metabolic diseases[1][2][3].

HY-NP006

Protein A

1 Publications Verification

SPA

Biochemical Assay Reagents

Protein A (SPA) is an immunoglobulin (Ig)-binding protein that exists on the bacterial surface and can be freely secreted into the extracellular environment. Protein A blocks opsonophagocytosis and induces B cell apoptosis in vitro by binding to the Fc region of antibodies and the Fab region of B cell receptors. Protein A can form toxic immune complexes with IgG, thereby inducing leukocyte necrosis. Protein A contributes to the virulence expression of Staphylococcus aureus. Protein A triggers allergic reactions in IgG-pretreated mouse models. Protein A can be used in studies related to immune system diseases .

HY-W591424

m-PEG2000-NHS ester

mPEG2000-SC; mPEG2000-Succinimidyl ester

Biochemical Assay Reagents

m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of MMP-2-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize MMP-2-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .

HY-156038

(S)-p-SCN-Bn-DOTA	Biochemical Assay Reagents
(S)-p-SCN-Bn-DOTA is a bifunctional chelator (BFC), a macrocyclic DOTA derivative for tumor pretargeting. (S)-p-SCN-Bn-DOTA can be used for the conjugation of peptides and radionuclides, such as as a linker for In-111 labeled radioimmunoconjugates (RICs) for single photon emission tomography (SPECT) and in vitro biodistribution studies .

HY-15001G

Stemregenin 1

SR1

Biochemical Assay Reagents

HY-139098

7-Methyl-diguanosine triphosphate

m7Gp3G

Biochemical Assay Reagents

7-Methyl-diguanosine triphosphate (m7Gp3G) is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .

HY-Y0850U5

PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

Polyvinyl alcohol (Mw 27000, 98-99% hydrolyzed, ~600 polymerization); Poly(Ethenol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization)

Biochemical Assay Reagents

PVA (Polyvinyl alcohol) (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) is a nonionic ethanol homopolymer with hydrophilicity, water solubility and biodegradability. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) exhibits biocompatibility, non-toxicity and non-carcinogenicity, as well as antibacterial activity against Gram-positive bacteria, Gram-negative bacteria and fungal strains. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can serve as a solubilizer, stabilizer, mucoadhesive agent and sustained-release agent, and has a synergistic solubilizing effect on voriconazole/sulfobutyl ether β-cyclodextrin complexes. By stabilizing such complexes, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) forms freeze-thaw hydrogels with high mucoadhesion, sustained drug release and ex vivo corneal permeability. When compounded with hyaluronic acid hydrogels, PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) supports chondrocyte growth in vitro, and also forms complexes with Cu ²⁺, Co ²⁺, Ni ²⁺ and Zn ²⁺ ions. PVA (Mw 27000, 98-99% hydrolyzed, ~600 polymerization) can be used in studies related to fungal keratitis, bacterial infections and fungal infections .

HY-16658BG

Z-VAD-FMK

Biochemical Assay Reagents

HY-NP0230

Bovine calmodulin	Biochemical Assay Reagents
Bovine calmodulin can be used for the in vitro phosphorylation assay of recombinant retinoic acid-induced gene I protein. Bovine calmodulin has also been used in studies of the hydrolysis and deamidation of the endopeptide Glu-C protein .

HY-W342458

Betamethasone 17-Propionate

Biochemical Assay Reagents

Betamethasone 17-Propionate is a compound used to study its effects on endotoxin-induced uveitis in rats. It has the activity of inhibiting the infiltration of cells into the aqueous humor in endotoxin-induced uveitis by eye drops and systemic administration at a certain dose. However, its inhibitory effect is relatively weak compared with some other compounds. At the same time, the dose for systemic administration is 1mg/kg. In addition, Betamethasone 17-Propionate has a weaker inhibitory effect on the release of IL-8 from rat peritoneal exudate cells in an in vitro interleukin-8 (IL-8) release assay than betamethasone. Moreover, the simultaneous addition of betamethasone dipropionate and betamethasone 17-Propionate reduces the inhibitory effect of betamethasone on cell infiltration and IL-1β gene expression.

Cat. No.	Product Name	Target	Research Area

HY-137875

Hippuryl-His-Leu-OH hydrate N-Benzoyl-Gly-His-Leu hydrate	Angiotensin-converting Enzyme (ACE) Amino Acid Derivatives	Cardiovascular Disease
Hippuryl-His-Leu-OH (N-Benzoyl-Gly-His-Leu) hydrate is a specific substrate for angiotensin-converting enzyme ACE I and is a molecular tool used for ACE activity detection in in vitro experiments. Hippuryl-His-Leu-OH hydrate is hydrolyzed by ACE through competitive binding. Under ACE catalysis, Hippuryl-His-Leu-OH hydrate undergoes hydrolysis to produce hippuric acid (HA). The amount of HA produced can be used to quantitatively assess ACE activity or screen for ACE inhibitors. The His-Leu released from Hippuryl-His-Leu-OH hydrate can also react with o-phthalaldehyde or Fluorescamine (HY-D0715) for fluorescence detection. Hippuryl-His-Leu-OH hydrate can be applied to the in vitro screening of ACE inhibitors for hypertension and cardiovascular diseases, and is also used in the study of changes in ACE activity during physiological and pathological processes such as renal compensatory hypertrophy .

HY-P10761

DPI-4452	Radionuclide-Drug Conjugates (RDCs) Carbonic Anhydrase	Cancer
DPI-4452 is a CAIX-targeting cyclic peptide with a DOTA cage, and can be chelated with radionuclide for CAIX-expressing tumor PET-CT imaging and study. DPI-4452 specifically and selectively binds CAIX without interaction with an in vitro off-target receptor panel of 55 targets (IC₅₀ for recombinant hCAIX: 130 nM). Radiolabeled DPI-4452 inhibits tumor growth in HT-29 and SK-RC-52 xenograft mouse models . DPI-4452 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).

HY-P4198

Fmoc-N(Me)-Sar10 Fmoc-Sar10	Biochemical Assay Reagents	Others
Fmoc-N(Me)-Sar10 (Fmoc-Sar10) is an Fmoc-protected derivative of a methylated sarcosine decamer, which supports cell adhesion, proliferation, and maintenance of cell phenotype. Fmoc-N(Me)-Sar10 is primarily used in peptide synthesis to introduce enzymatically stable spacer sequences. By mimicking the extracellular matrix (ECM), Fmoc-N(Me)-Sar10 provides a 3D growth microenvironment for cells and is mainly used in tissue engineering and 3D cell culture, particularly suitable for in vitro culture studies of cells such as chondrocytes .

HY-W048825

Fmoc-Ala-Ala-OH	Amino Acid Derivatives	Others
Fmoc-Ala-Ala-OH is a self-assembling fluorenylmethoxycarbonyl dipeptide, a small amphiphilic building block composed of a dipeptide linked to a fluorenylmethoxycarbonyl (Fmoc) group. Under conditions of pH < 4, Fmoc-Ala-Ala-OH spontaneously assembles to form a nanofiber network, constructing a hydrogel scaffold with a water content exceeding 99% (w/w). The fibers have a diameter of approximately 22 nm, matching the size of extracellular matrix (ECM) components. Fmoc-Ala-Ala-OH supports cell adhesion, proliferation, and maintains of cell phenotype. Fmoc-Ala-Ala-OH's function is to mimic the ECM, providing a 3D growth microenvironment for cells, and Fmoc-Ala-Ala-OH is primarily used in tissue engineering and 3D cell culture, particularly suitable for in vitro culture studies of cells such as chondrocytes[1] .

HY-P11117

TAT-EE3	TRP Channel iGluR Calcium Channel	Neurological Disease
TAT-EE3 is a neuroprotective peptide which can uncouple TRPM2-NMDARs interaction. TAT-EE3 inhibits TRPM2-induced enhancement of NMDAR surface expression and current amplitude.TAT-EE3 protects neurons against ischemic injury in vitro and in vivo. TAT-EE3can be used for the study of ischemic stroke .

HY-P1435

NoxA1ds	NADPH Oxidase	Cardiovascular Disease Cancer
NoxA1ds is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds inhibits NOX1-derived O ^2- production in HT-29 human colon cancer cells. NoxA1ds attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds can be used in the study of hypertension, atherosclerosis and tumors .

HY-P3397A

JV-1-36 acetate	GHSR	Cancer
JV-1-36 acetate is a growth hormone-releasing hormone (GHRH) antagonist. JV-1-36 acetate inhibits the production of reactive oxygen species in A549 lung cancer cells. JV-1-36 can be used to study the effect of GHRH antagonists in vitro .

HY-P10841

CyPep-1	Amino Acid Derivatives	Cancer
CyPep-1 is a novel cationic lytic peptide with antitumor activity. CyPep-1 is highly cytotoxic by interacting with the negatively charged cell membrane of cancer cells. CyPep-1 has strong cytolytic activity on cancer cells both in vivo and in vitro, and can be used in the study of solid tumors .

HY-P4126

Suc-Ala-Ala-Pro-Val-AMC	Elastase	Others
Suc-Ala-Ala-Pro-Val-AMC is a fluorescent substrate for elastase. Suc-Ala-Ala-Pro-Val-AMC can be hydrolyzed by these elastases to release the fluorescent substance 7-amino-4-methylcoumarin. Suc-Ala-Ala-Pro-Val-AMC is used for in vitro elastase activity assays and can also be applied in studies related to chronic wounds .

HY-P4551

Hippuryl-His-Leu-OH N-Benzoyl-Gly-His-Leu	Angiotensin-converting Enzyme (ACE) Amino Acid Derivatives	Cardiovascular Disease
Hippuryl-His-Leu-OH (N-Benzoyl-Gly-His-Leu) is a specific substrate for angiotensin-converting enzyme (ACE I) and a molecular tool used for ACE activity detection in in vitro experiments. Hippuryl-His-Leu-OH is hydrolyzed by ACE through competitive binding. Under ACE catalysis, Hippuryl-His-Leu-OH undergoes hydrolysis to produce hippuric acid (HA). The amount of HA produced can be used to quantitatively assess ACE activity or screen for ACE inhibitors. The released His-Leu can also react with o-phthalaldehyde or Fluorescamine (HY-D0715) for fluorescence detection. Hippuryl-His-Leu-OH can be applied to the in vitro screening of ACE inhibitors for hypertension and cardiovascular diseases, and is also used in the study of ACE activity changes in physiological and pathological processes such as renal compensatory hypertrophy .

HY-P3397

JV-1-36	GHSR	Cancer
JV-1-36 is a growth hormone-releasing hormone (GHRH) antagonist. JV-1-36 inhibits the production of reactive oxygen species in A549 lung cancer cells. JV-1-36 can be used to study the effect of GHRH antagonists in vitro .

HY-P10889

CNI103	Phosphatase	Inflammation/Immunology
CNI103 is a highly potent and metabolically stable cell-permeable peptide inhibitor of calcineurin. CNI103 selectively blocks the interaction between calcineurin and NFATc3 (K_D=16 nM), thereby preventing NFATc3 activation in vitro and in vivo. CNI103 can be used to study acute respiratory distress syndrome (ARDS) and other inflammatory diseases .

HY-P11088

VCAM1 binding peptide	Transmembrane Glycoprotein Radionuclide-Drug Conjugates (RDCs)	Inflammation/Immunology
VCAM1 binding peptide is a VCAM1 binder with internalization activity. VCAM1 binding peptide can be labeled with 5-FAM. VCAM1 binding peptide serves as a component of biosensing systems for visualizing in vitro VCAM1 endocytic pathways. VCAM1 binding peptide forms the research and development basis for MacroP and NAMP, PET radiotracers targeting VCAM1. VCAM1 binding peptide is applicable to studies related to atherosclerosis .

HY-P5107A

Low molecular weight protamine acetate LMWP acetate; TDSP5 acetate	VEGFR	Cancer
Low molecular weight protamine (LMWP) is a truncated arginine-rich protamine peptide, which also acts as an antidote for heparin/low molecular weight heparin and a cell-penetrating delivery vector. Low molecular weight protamine neutralizes heparin-induced anticoagulant activities, including aPTT, anti-Xa and anti-IIa activities. Low molecular weight protamine translocates across mammalian cell membranes, delivers conjugated impermeable molecules through tumor tissues, enhances the skin permeability of conjugated epidermal growth factor, and accelerates wound healing when conjugated with epidermal growth factor. Low molecular weight protamine retains the in vitro cell proliferation activity of conjugated EGF, and also enables site-specific conjugation with peptides or proteins via genetic recombination. Low molecular weight protamine can be used in studies related to colon cancer, skin wounds and diabetic skin wounds .

HY-P10526

CRAMP (1-39)	Bacterial	Infection
CRAMP (1-39) is an antimicrobial peptide. CRAMP (1-39) has shown potent bactericidal effects against multiple strains of Neisseria meningitidis in vitro. CRAMP (1-39) can be used to study drug-resistant bacterial infections .

HY-P10453

Myr5A peptide	Peptides	Others
Myr5A peptide is an acylated peptide composed of apolipoprotein A1 (ApoA1) analog peptide 5A peptide coupled to the saturated fatty acid myristate. Myr5A peptide self-assembled into lipid nanostructures can be used to encapsulate anthracycline Doxorubicin (HY-15142A) and Valrubicin (HY-13772) for compound release studies in vitro .

HY-P10469

NBD-2	NF-κB	Inflammation/Immunology Cancer
NBD-2 is an inhibitor of the NEMO-IKKα/β interaction in the NF-κB signaling pathway. NBD-2 specifically inhibits the typical NF-κB signaling pathway in vitro and in vivo, reducing the inflammatory response in lipopolysaccharide (LPS) induced acute lung injury (ALI). NBD-2 exhibits significant anti-inflammatory activity. NBD-2 can be used to study diseases related to NF-κB signaling pathway, including autoimmune diseases, cancer, etc .

HY-P1435A

NoxA1ds TFA	NADPH Oxidase	Cardiovascular Disease Cancer
NoxA1ds TFA is a potent and highly selective NADPH oxidase 1 (NOX1) inhibitor (IC₅₀=20 nM). NoxA1ds TFA inhibits NOX1-derived O ^2- production in HT-29 human colon cancer cells. NoxA1ds TFA attenuates VEGF-induced human pulmonary artery endothelial cell migration under hypoxic conditions in vitro. NoxA1ds TFA can be used in the study of hypertension, atherosclerosis and tumors .

HY-P0038

MK-852 L-367073	Integrin	Cardiovascular Disease
MK-852 (L-367073) is an effective GPIIb/IIIa receptor antagonist. MK-852 can significantly inhibit the binding of fibrinogen to platelets in vitro. MK-852can be used for the study of thrombosis .

HY-114118F4

Semaglutide-FITC Semaglutide-Lys(FITC)	Fluorescent Dye GLP Receptor	Metabolic Disease
Semaglutide-FITC (Semaglutide-Lys(FITC)) is a FITC-labeled Semaglutide (a GLP-1R agonist) (HY-114118). Semaglutide-FITC can be used to directly track the distribution, cellular uptake, and transmembrane transport process of vesicles through techniques such as fluorescence imaging and flow cytometry. Semaglutide-FITC can be employed to study the movement and penetration ability of mixed vesicles in porcine intestinal mucus in vitro .

HY-180346

Hepta-histidine	Huntingtin	Neurological Disease
Hepta-histidine is an inhibitor of Ku70-Huntingtin protein interaction. Hepta-histidine can reverse the morphological abnormalities of primary neurons differentiatied from hiPSCs. Hepta-histidine prolongs the lifespan in severe Huntington’s disease R6/2 mouse model. Hepta-histidine ameliorates DNA damage in vitro. Hepta-histidine can be used to study anti-aggregation agent against Tau-associated neurodegenerative diseases such as Alzheimer’s disease and Huntington’s disease .

HY-P11612

ATS-9R	Biochemical Assay Reagents	Metabolic Disease
ATS-9R is a peptide consisting of an adipocyte-targeting sequence and D-form 9-arginine. ATS-9R selectively transfects mature adipocytes by binding to prohibitin. ATS-9R allows an adipocyte-targeted gene delivery in vitro and in vivo. ATS-9R can be used for the development of an adipocyte-targeted gene carrier. ATS-9R can be used for the study of obesity as well as obesity-induced metabolic syndromes .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99019

Fremanezumab 2 Publications Verification TEV-48125; LBR-101; PF-04427429; RN-307	CGRP Receptor	Neurological Disease Inflammation/Immunology
Fremanezumab (TEV-48125) is a humanized lgG2 monoclonal antibody that selectively and potently binds to calcitonin gene related peptide (CGRp) (IC₅₀ values = 7.943 nM). Fremanezumab binds to mouse CGRP with an IC₅₀ value of 19.6 nM. Fremanezumab counteracts anti-inflammatory effects of CGRP in vitro, including CGRP-mediated inhibition of LPS (HY-D1056)-induced microglial activation. Fremanezumab selectively inhibits the activation of Aδ meningeal nociceptors by cortical spreading depression (CSD) in rats. Fremanezumab can be used for the study of inflammation and chronic migraine .

HY-P991758

Anti-Mouse PDGFRα Antibody (APA5)	PDGFR	Cardiovascular Disease
Anti-Mouse PDGFRα Antibody (APA5) reacts with mouse PDGFRα. Anti-Mouse PDGFRα Antibody (APA5) can be used to block PDGFRα in vitro and in vivo. Anti-Mouse PDGFRα Antibody (APA5) can be used for the study of pulmonary hypertension. Recommend Isotype Controls: Rat IgG2a kappa, Isotype Control (HY-P990679) .

HY-P992056

Anti-Human/Mouse LY6E Antibody (9B12)	Autophagy	Cancer
Anti-Human/Mouse LY6E Antibody (9B12) is a high-affinity, multi-target antibody that binds specifically to LY6E. Anti-Human/Mouse LY6E Antibody (9B12) binds specifically to cell-surface LY6E and enters lysosomes via lipid raft-dependent endocytosis, thereby effectively inhibiting the growth of various LY6E-expressing solid tumors (such as breast cancer and lung cancer) in both in vitro and in vivo models. Anti-Human/Mouse LY6E Antibody (9B12) exerts a dual mechanism of action: on one hand, it blocks the interaction between PILRα and CD8α, specifically reduces the survival rate of peripheral CD8 ⁺ T cells and induces their activation, breaking the state of cellular quiescence; on the other hand, it recognizes and immunoprecipitates IDE under both non-denaturing and denaturing conditions, which is applicable to studies on the subcellular localization and protein interactions of IDE. The regulatory effect of Anti-Human/Mouse LY6E Antibody (9B12) on CD8 ⁺ T cells strictly depends on the presence of PILRα, and it does not affect CD4 ⁺ T cells or T cell development in the thymus, exhibiting high specificity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-113071A

Mevalonic acid lithium salt Maximum Cited Publications 10 Publications Verification MVA lithium salt	Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite
Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure .

HY-N0667

L-Asparagine 5 Publications Verification (-)-Asparagine; Asn; Asparamide	Neurological Disease Classification of Application Fields Amino acids Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite Apoptosis DNA/RNA Synthesis
L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-113071

Mevalonic acid MVA	Human Gut Microbiota Metabolites Immune System Disorder Classification of Application Fields Ketones, Aldehydes, Acids Disease markers Other Diseases Endocrine diseases Nervous System Disorder Endogenous metabolite Disease Research Fields	Endogenous Metabolite
Mevalonic acid (MVA) is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid can be used in studies of myopathy and heart failure .

HY-N6703

ar-Turmerone (+)-ar-Turmerone	Structural Classification Classification of Application Fields Ketones, Aldehydes, Acids Plants Curcuma longa Inflammation/Immunology Disease Research Fields Source Classification Zingiberaceae	Apoptosis
ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .

HY-W017443

L-Asparagine monohydrate 5 Publications Verification	Classification of Application Fields Metabolic Disease Amino acids Endogenous metabolite Disease Research Fields Source Classification	Endogenous Metabolite Apoptosis DNA/RNA Synthesis
L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-14608R

L-Glutamic acid (Standard)	Structural Classification Microorganisms Disease markers Endocrine diseases Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer Source Classification	Reference Standards Endogenous Metabolite iGluR Ferroptosis Apoptosis
L-Glutamic acid (Standard) is the analytical standard of L-Glutamic acid. This product is intended for research and analytical applications. L-Glutamic acid is an excitatory amino acid neurotransmitter that acts as an agonist for all subtypes of glutamate receptors (metabolic rhodophylline, NMDA, and AMPA). L-Glutamic acid has an agonist effect on the release of DA from dopaminergic nerve endings. L-Glutamic acid can be used in the study of neurological diseases . IC₅₀ & Target:DA . In Vitro: L-Glutamic acid (120, 500, 750, 1000 mg/dL) can reduce the harmful effect of lithium on the embryonic development of Xenopus Xenopus . L-Glutamic acid (2, 5, 10, 20 mM, 24-48 h) can induce neuroexcitotoxicity in neuroblastoma . In Vivo: L-Glutamic acid (3 g/kg, subcutaneous injection) can promote excitotoxic degeneration of retinal ganglion cells in mice . L-Glutamic acid (750 mg/kg, intraperitoneal injection) can reduce and inhibit oxidative stress induced by chlorpyrifos (CPF) in rats .

HY-N0667R

L-Asparagine (Standard) (-)-Asparagine (Standard); Asn (Standard); Asparamide (Standard)	Structural Classification Immune System Disorder Microorganisms Disease markers Amino acids Nervous System Disorder Endogenous metabolite Cardiovascular System Disorder Cancer Source Classification	Reference Standards Endogenous Metabolite Apoptosis DNA/RNA Synthesis
L-Asparagine (Standard) is the analytical standard of L-Asparagine (HY-N0667). This product is intended for research and analytical applications. L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N6865

Groenlandicine 2 Publications Verification	Structural Classification Classification of Application Fields Ranunculaceae Metabolic Disease Plants Alkaloids Piperidine Alkaloids Monophenols Coptis chinensis Franch. Phenols Isoquinoline Alkaloids Disease Research Fields Source Classification	Cholinesterase (ChE) Topoisomerase Reactive Oxygen Species (ROS) Beta-secretase Apoptosis
Groenlandicine, a protoberberine alkaloid, is a cholinesterase inhibitor (AChE (IC₅₀ = 0.54 μM), BChE (IC₅₀ = 3.32 μM)). Groenlandicine non-competitively inhibits BACE1 (IC₅₀ = 19.68 μM, K_i = 21.2) and inhibits RLAR (IC₅₀ = 140.1 μM), HRAR (IC₅₀ = 154.2 μM), and total ROS generation (IC₅₀ = 51.78 μM) in vitro. Groenlandicine suppresses osteosarcoma cell proliferation while promoting apoptosis. Groenlandicine inhibits the tumor growth when combined with Cisplatin (HY-17394). Groenlandicine can be used for the study on osteosarcoma, Alzheimer's disease and diabetes mellitus .

HY-W017443R

L-Asparagine monohydrate (Standard)	Structural Classification Amino acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite Apoptosis DNA/RNA Synthesis
L-Asparagine monohydrate (Standard) is the analytical standard of L-Asparagine monohydrate (HY-W017443). This product is intended for research and analytical applications. L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-117818

Sapurimycin Antibiotic DC 116	Microorganisms Antibiotics Disease Research Anticancer Source Classification	Antibiotic
Sapurimycin is an antitumor antibiotic isolated from Streptomyces DO-116 and belongs to the capramycin family. Sapurimycin exhibits potent activity against Gram-positive bacteria and exhibits significant antitumor effects against leukemia P388 and sarcoma 180 in mouse models. In vitro studies have shown that Sapurimycin can induce single-strand breaks in supercoiled plasmid DNA .

HY-113071AR

Mevalonic acid lithium salt (Standard) MVA lithium salt (Standard)	Structural Classification Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Mevalonic acid lithium salt (Standard) is the analytical standard of Mevalonic acid lithium salt. This product is intended for research and analytical applications. Mevalonic acid (MVA) lithium salt is a precursor substance of the mevalonate pathway, which is essential for cell growth and proliferation. Mevalonic acid lithium salt is effective in inhibiting Simvastatin (HY-17502)-induced decrease in C2C12 cell viability in vitro. Mevalonic acid lithium salt can be used in studies of myopathy and heart failure .

HY-N7236

Pervicoside B	Triterpenes Animals Terpenoids Source Classification	Parasite Fungal
Pervicoside B is a glycoside C isolated from Neothyone gibbosa sea cucumber. In vitro studies have shown that Pervicoside B has a potent antiparasitic effect against Leishmania mexicana, inhibiting 100% of promastigotes at 5-10 μg/mL. Pervicoside B also exhibits strong antifungal activity against Aspergillus niger, with MIC values ranging from 4.65 to 16.7 μg/mL. Pervicoside B has potential applications in the inhibition of parasitic infections and fungal diseases .

HY-186179

N-Methylnorsalsolinol	Structural Classification Monophenols Phenols Endogenous metabolite Source Classification	Endogenous Metabolite
N-Methylnorsalsolinol is an endogenous MPTP (HY-15608)-like compound. N-Methylnorsalsolinol shows neurotoxicity in vitro. N-Methylnorsalsolinol can be used for the study of Parkinson’s disease .

HY-179519

Umbelopsisin A	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	GABA Receptor Reactive Oxygen Species (ROS)
Umbelopsisin A is a GABA_A and GABA_B non-selective agonist. Umbelopsisin A activates the GABAergic pathway, including notch signaling and fatty acid metabolism. Umbelopsisin A shows dual neuroprotection against glutamate excitotoxicity in vitro (reducing ROS and cell death) and in vivo. Umbelopsisin A can be used for the study of glaucoma and broader neurodegenerative disease applications .

HY-N19782

Striatisporolide A	Athyriaceae Structural Classification Ketones, Aldehydes, Acids Athyrium multidentatum (Döll) Ching Plants Source Classification	Bacterial Apoptosis Reactive Oxygen Species (ROS)
Striatisporolide A is an antibacterial agent. Striatisporolide A exhibits antibacterial activity against Escherichia coli in vitro. Striatisporolide A damages the cell wall and cell membrane of Escherichia coli, and induces changes in protein levels and morphology. Striatisporolide A reduces the level of apoptosis (apoptosis) in HUVECs, inhibits excessive production of ROS, and possesses pro-proliferative and mild cytoprotective effects. Striatisporolide A can be used in studies related to bacterial infections and degenerative diseases .

HY-N19297

Endosidin1 Prieurianin	Structural Classification Natural Products Arabidopsis thaliana (L.) Heynh. Plants Brassicaceae Source Classification	Elastase
Endosidin1 (Prieurianin) is a Prieurianin with cleaved A and B rings. Endosidin1 is isolated from the roots of Aphanamixis polystachya. Endosidin1 inhibits superoxide anion production and Elastase release in neutrophils, with an IC₅₀ >10 μg/mL. Endosidin1 exhibits mild cytotoxic activity against laryngeal cancer cells in vitro. Endosidin1 shows anti-inflammatory activity. Endosidin1 can be used in studies related to laryngeal cancer .\n

Cat. No.	Product Name	Chemical Structure

HY-110228

Metformin-d6 hydrochloride

Metformin-d₆ hydrochloride is a deuterium labeled Metformin hydrochloride. Metformin hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

HY-N0667S2

L-Asparagine-15N2 monohydrate

1 Publications Verification

L-Asparagine- ¹⁵N₂ monohydrate is the ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0667S5

L-Asparagine-d3 hydrate

1 Publications Verification

L-Asparagine-d₃ hydrate is the deuterium labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-B0627S

Metformin-d6

Metformin-d₆ (1,1-Dimethylbiguanide-d₆) is a deuterated labeled Metformin (HY-B0627). Metformin (1,1-Dimethylbiguanide) inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

HY-W017443S

L-Asparagine-13C4,15N2 monohydrate

L-Asparagine- ¹³C₄, ¹⁵N₂ monohydrateis the ¹³C-labeled and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-B1462S

Chlorzoxazone-d3
Chlorzoxazone-d₃ is the deuterium labeled Chlorzoxazone. Chlorzoxazone is a centrally acting muscle relaxant used to treat muscle spasm and the resulting pain or discomfort. It acts on the spinal cord by depressing reflexes.Chlorzoxazone is currently being used as a marker substrate in vitro/vivo studies to quantify cytochrome P450 2E1 (CYP2E1) activity in humans.

HY-N0667S3

L-Asparagine-13C4 monohydrate

L-Asparagine- ¹³C₄ monohydrate is the ¹³C-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W017443S1

L-Asparagine-amide-15N monohydrate

L-Asparagine-amide- ¹⁵N monohydrate is the ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0667S7

L-Asparagine-13C4,15N2

L-Asparagine- ¹³C₄, ¹⁵N₂ ((-)-Asparagine- ¹³C₄, ¹⁵N₂) is the ¹³C and ¹⁵N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-B0627S1

Metformin-13C2 hydrochloride

Metformin- ¹³C₂ (1,1-Dimethylbiguanide- ¹³C₂) hydrochloride is the ¹³C-labeled Metformin hydrochloride (HY-17471A). Metformin (1,1-Dimethylbiguanide) hydrochloride inhibits the mitochondrial respiratory chain in the liver, leading to AMPK activation and enhancing insulin sensitivity, and can be used in the study of type 2 diabetes. Metformin hydrochloride exerts central glucose-lowering effects by inhibiting Ras-related protein 1 (Rap1) in SF1 hypothalamic neurons. Metformin hydrochloride also inhibits liver oxidative stress, nitrosative stress, inflammation, and apoptosis caused by liver ischemia/reperfusion injury. In addition, Metformin hydrochloride regulates the expression of autophagy-related proteins by activating AMPK and inhibiting the mTOR signaling pathway, thereby inducing tumor cell autophagy and inhibiting the growth of renal cell carcinoma in vitro and in vivo .

HY-B1148AS

Furaltadone-d5
Furaltadone-d₅ is the deuterium labeled Furaltadone (HY-B1148A). Furaltadone, a nitrofuran agent, has the potential for the study in infections of chickens with salmonella enteritidis. Furaltadone is inhibitory and bactericidal in vitro for staphylococci .

HY-N6703S

ar-Turmerone-d3

ar-Turmerone-d₃ is the deuterium labeled ar-Turmerone. ar-Turmerone ((+)-ar-Turmerone) is an orally active and major bioactive compound of the herb Curcuma longa with anti-tumorigenesis and anti-inflammatory activities. ar-Turmerone induces apoptosis in U937 cells. ar-Turmerone exerts positive modulation on murine DCs. ar-Turmerone induces NSC proliferation in vitro and in vivo, and can be used for various neurologic disorders study .

HY-W014839S

Cyclamic acid-d11 sodium

Cyclamic acid-d₁₁ (Sodium cyclamate-d₁₁) sodiumis deuterium labeled Cyclamic acid (sodium). Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine .

HY-W014839S1

Cyclamic acid-d4 sodium

Cyclamic acid-d₄ (Sodium cyclamate-d₄) sodium is the deuterium labeled Cyclamic acid sodium (HY-W014839). Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine .

HY-N0667S1

L-Asparagine-15N2,d8

L-Asparagine- ¹⁵N₂,d₈ is the ¹⁵N- and deuterium labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0667S4

L-Asparagine-4-13C monohydrate

L-Asparagine-4- ¹³C monohydrate is the ¹³C-labeled L-Asparagine monohydrate (HY-W017443).L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W017443S4

L-Asparagine-1,2,3,4-13C4 monohydrate

L-Asparagine-1,2,3,4- ¹³C₄ monohydrate is the ¹³C labeled labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-N0667S

L-Asparagine-13C4,15N2,d8

L-Asparagine- ¹³C₄, ¹⁵N₂,d₈ is the ¹³C-labeled and ¹⁵N-labeled L-Asparagine (HY-N0667). L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W017443S2

L-Asparagine-13C4,15N2,d3 monohydrate

L-Asparagine- ¹³C₄, ¹⁵N₂,d₃ monohydrate is the deuterium, ¹³C-, and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W017443S3

L-Asparagine-15N2,d3 monohydrate

L-Asparagine- ¹⁵N₂,d₃ monohydrate is the deuterium and ¹⁵N-labeled L-Asparagine monohydrate (HY-W017443). L-Asparagine monohydrate is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine monohydrate can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W142432S

Perfluoroundecanoic acid-13C7

Perfluoroundecanoic acid- ¹³C₇ is the ¹³C-labeled Perfluoroundecanoic acid (HY-W142432). Perfluoroundecanoic acid is a perfluoroalkyl substance (PFAS). Perfluoroundecanoic acid is an orally active oxidative stress inducer. Perfluoroundecanoic acid promotes macrophage M2 polarization, activates Wnt/β-catenin signaling and enhances β-catenin nuclear accumulation. Perfluoroundecanoic acid -induced M2 phenotype macrophage accelerates tumor progression in vitro and in vivo. Perfluoroundecanoic acid induces DNA damage, reproductive and pathophysiological dysfunctions via oxidative stress in male Swiss mice. Perfluoroundecanoic acid inhibits Leydig cell development in pubertal male rats via inducing oxidative stress and autophagy. Perfluoroundecanoic acid accelerates insulitis development in a mouse model of type 1 diabetes. Perfluoroundecanoic acid can be used for the study of ovarian cancer, type 1 diabetes and inflammation .

Cat. No.	Product Name		Classification

HY-N0667

L-Asparagine 5 Publications Verification (-)-Asparagine; Asn; Asparamide		Freeze-drying Protective Agents Solubilizing Agents
L-Asparagine is an essential amino acid for leukemic cells and a substrate for L-Asparaginase. L-Asparaginase is a potent anti-leukemic enzyme that promotes asparagine (Asn) and glutamine (Gln) depletion and inhibits protein biosynthesis in lymphoblasts. Removal of L-asparagine from plasma by L-Asparaginase results in inhibition of RNA and DNA synthesis and subsequent apoptosis. L-Asparaginase has cell-killing ability in vitro and in vivo, and selectively inhibits the growth of cancer cells with low asparagine synthetase (AASNS) expression. L-Asparagine can be used as a biomarker and sensor for the study of childhood acute lymphoblastic leukemia .

HY-W014839

Cyclamic acid sodium Sodium cyclamate; Cyclohexylsulfamic acid sodium		Sweetening Agents
Cyclamic acid sodium (Sodium cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine .

HY-W591424

m-PEG2000-NHS ester mPEG2000-SC; mPEG2000-Succinimidyl ester		Polymers
m-PEG2000-NHS ester (mPEG2000-SC) is a reagent with both cell adhesion inhibition and peptide conjugation functions. The NHS ester group of m-PEG2000-NHS ester forms stable amide bonds with primary amine-containing molecules (e.g., the N-terminus of MMP-2-cleavable octapeptide) to generate mPEG-peptide intermediates for liposome surface modification. When m-PEG2000-NHS ester is immobilized on a cystamine-modified gold surface, it can construct an in vitro model for cell adhesion kinetic studies, and higher PEG density and thicker layers correlate with lower cell adhesion rates. m-PEG2000-NHS ester can synthesize MMP-2-responsive PEGylated lipid conjugates to achieve MMP-triggered dePEGylation in the tumor microenvironment. m-PEG2000-NHS ester can be used in studies related to colon cancer and other conditions .

HY-171499

Cenersen EL625		Antisense Oligonucleotides
Cenersen (EL625) is an oligonucleotide targeting TP53. Cenersen can eliminate the activity of TP53 gain-of-function mutants and increase the sensitivity of lymphoma cells to cytotoxic chemotherapy in vitro. Cenersen can be used for the study of chronic lymphocytic leukemia (CLL) .

HY-139098

7-Methyl-diguanosine triphosphate m7Gp3G		Cap Analogs
7-Methyl-diguanosine triphosphate (m7Gp3G) is an mRNA cap structure analog that inhibits in vitro protein synthesis by binding to the translation initiation complex. 7-Methyl-diguanosine triphosphate binds to eIF4E, promotes cap-dependent translation initiation, stabilizes mRNA, and acts as a translation enhancer. 7-Methyl-diguanosine triphosphate can be used to prepare synthetic capped RNA transcripts for studies related to mRNA translation, splicing, turnover, and intracellular transport .

HY-148947

Cy5 Phosphoramidite		Phosphoramidites Fluorescent Dye Phosphoramidite
Cy5 Phosphoramidite is a fluorescent labeling reagent . Cy5 Phosphoramidite serves as a fluorescent tag for 3' terminal labeling of single-stranded DNA, enabling fluorescence-based nucleic acid detection, monitoring, quantification, and in vitro study .

HY-177921

PL53		Phospholipids
PL53 is a kind of cycloalkylamine lipid nanoparticles. PL53 exhibits outstanding transfection efficiency both in vitro and in vivo, especially showing strong protein expression ability and potential tissue targeting after intramuscular injection. PL53 can be used for the study of nucleic acid delivery .

Targets Recommended: Dan family AIM2 CD44 NEKs

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-15001G

Stemregenin 1 SR1	Aryl Hydrocarbon Receptor	Cancer
Stemregenin 1 (SR1) (GMP) is a GMP-grade Stemregenin 1 (HY-15001). GMP-grade small molecules can be used as adjuvants in cell therapy. Stemregenin 1 is a potent aryl hydrocarbon receptor (AhR) antagonist with an IC₅₀ of 127 nM. Stemregenin 1 (GMP) can competitively bind to AhR and inhibit its nuclear translocation, inhibiting osteoclastogenesis and promoting hematopoietic progenitor cell expansion by blocking the AhR-c-src-NF-κB/p-ERK MAPK-NFATc1 signaling pathway. Stemregenin 1 (GMP) can be used for the study of osteoporosis, in vitro expansion of hematopoietic stem cells, and the study of the mechanism of bone metabolic diseases .

HY-16658BG

Z-VAD-FMK	Caspase Apoptosis	Cancer
Z-VAD-FMK is a pan-caspase inhibitor and also an ICE-like protease inhibitor, which inhibits apoptosis by preventing the processing of CPP32 to its active form. Z-VAD-FMK sensitivity varies primarily due to differential expression of receptor-interacting protein 1 (RIP1). Z-VAD-FMK limits the cryopreservation-induced apoptosis by reducing caspase-3 activity of in vitro produced bovine embryos. Z-VAD-FMK is immunosuppressive in vitro and inhibits T cell proliferation without blocking the processing of caspase-8 and caspase-3. Z-VAD-FMK leads to a decrease in intracellular glutathione (GSH) with a concomitant increase in reactive oxygen species (ROS) levels in activated T cells. Z-VAD-FMK is due to oxidative stress via the depletion of GSH. Z-VAD-FMK can be used for the study of acute pancreatitis .

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