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Results for "

juvenile hormone

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Autophagy (4) Biochemical Assay Reagents (2) c-Met/HGFR (1) Cannabinoid Receptor (1) CRFR (2) Drug Derivative (1) Endogenous Metabolite (2) Environmental Pollutants (3) Insecticide (6) Isotope-Labeled Compounds (4) Melanocortin Receptor (2) Parasite (5) Potassium Channel (1) Reference Standards (3)
By Research Areas:	Endocrinology (2) Infection (6) Inflammation/Immunology (3) Metabolic Disease (4) Neurological Disease (5)

Inhibitors & Agonists

Screening Libraries

Peptides

Natural
Products

Isotope-Labeled Compounds

Targets Recommended: Thyroid Hormone Receptor PTHR GHR Nuclear Hormone Receptor 4A/NR4A TSH Receptor MCHR1 (GPR24) GHSR Hormone-Sensitive Lipase (HSL) GnRH Receptor

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-B1161

Methoprene Maximum Cited Publications 15 Publications Verification ZR-515	Environmental Pollutants Insecticide	Others
Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a **juvenile hormone** agonist .

HY-B1161A

S-Methoprene 2 Publications Verification (+)-Methoprene; (7S)-Methoprene	Environmental Pollutants Cannabinoid Receptor	Others
S-Methoprene is an insect juvenile hormone analog and effective insecticide that blocks the transition from pupa to adult. S-Methoprene is also a CB(1) receptor ligand and inhibits the binding of the CB1 receptor antagonist [ ³H]CP-55940 to the CB1 receptor (IC₅₀: 19.31 μM) .

HY-N7240

*(Rac)-Juvenile* hormone III**	Others	Metabolic Disease
(Rac)-Juvenile hormone III is a cecropia juvenile hormone and juvenile hormone agonist. (Rac)-Juvenile hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile hormone III possesses morphogenetic activity in insect assays .

HY-B2031

Pyriproxyfen 1 Publications Verification S-31183	Autophagy Parasite	Infection
Pyriproxyfen (S-31183) is a juvenile hormone analog and insect growth regulator. Pyriproxyfen is used in research related to dengue fever and malaria .

HY-P0060

Tetracosactide Tetracosactrin; ACTH(1–24)	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P0060A

Tetracosactide acetate Tetracosactrin acetate; ACTH(1–24) acetate	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-122940

Precocene II Ageratochromene	Endogenous Metabolite	Metabolic Disease
Precocene II (Ageratochromene) is a plant larva hormone antagonists that inhibits the biosynthesis of **juvenile hormone*. Precocene II inhibits corpora allata function and downregulates juvenile* hormone levels, while exerting multiple effects including inducing precocious metamorphosis, forming macropterous morphs, inhibiting ovarian growth, producing cytotoxicity, disrupting insect development, and causing sterility and kidney damage. Precocene II blocks normal nymphal development, causes renal tubular damage and increases blood urea nitrogen levels, and also blocks juvenile hormone biosynthesis in vitro. Precocene II undergoes oxidative metabolism catalyzed by NADPH-dependent monooxygenase to generate a variety of metabolites. Precocene II can be applied in studies related to insect growth regulation and nephrotoxicity .

HY-N7240S

*(Rac)-Juvenile* Hormone III-d3**	Isotope-Labeled Compounds Others	Others
Juvenile Hormone III-d₃ is the deuterium labeled Juvenile Hormone III. (Rac)-Juvenile Hormone III is a cecropia juvenile hormone and juvenile hormone agonist. (Rac)-Juvenile Hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile Hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile Hormone III possesses morphogenetic activity in insect assays .

HY-122062

Fenoxycarb 1 Publications Verification	Environmental Pollutants Insecticide	Others
Fenoxycarb, a juvenile hormone, is an insecticide and can be used for agricultural pest control .

HY-B2031R

Pyriproxyfen (Standard) S-31183 (Standard)	Reference Standards Autophagy Parasite	Infection
Pyriproxyfen (S-31183) (Standard) is the analytical standard of Pyriproxyfen. This product is intended for research and analytical applications. Pyriproxyfen is a juvenile hormone analog and insect growth regulator. Pyriproxyfen is used in research related to dengue fever and malaria .

HY-P1882

Type A Allatostatin I	Insecticide	Inflammation/Immunology
Type A Allatostatin I is a tridecapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-B1161R

Methoprene (Standard) ZR-515 (Standard)	Insecticide Reference Standards	Others
Methoprene (Standard) is the analytical standard of Methoprene. This product is intended for research and analytical applications. Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist .

HY-W587689

Juvenile hormone B 3 (mixture of diastereomers) juvenile hormone III bisepoxide; juvenile hormone bisepoxide; JHB3	c-Met/HGFR	Others
Juvenile hormone B 3 (Juvenile hormone III bisepoxide)(mixture of diastereomers) is a sesquiterpenoid hormone. Juvenile hormone B 3 can be isolated from corpus allatum (CA) of high dipterans like the fruitfly and Drosophila melanogaster. JHB3 has anti-metamorphic activity and induces Kr-h1 expression by directly interacting with juvenile hormone (JH) receptors (Met and Gce). Juvenile hormone B 3 can be used for insect lethality research .

HY-P1786

Allatostatin II	Potassium Channel	Neurological Disease
Allatostatin II is a decapeptid. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-P5866

Allatotropin Manse-AT	Endogenous Metabolite	Endocrinology
Allatotropin (Manse-AT) is a 13 amino acid neuropeptide. Allatotropin activates inositol 1,4,5-trisphosphate (IP3) pathway, and the biosynthesis of juvenile hormone (JH) in Manduca sexta .

HY-122530

Juvocimene I	Insecticide	Endocrinology
Juvocimene I is a potent juvenile hormone mimic. Juvocimene I can be isolated from the essential oil of sweet basil,Ocimum basilicum L .

HY-B1161S

Methoprene-d7 ZR-515-d₇	Isotope-Labeled Compounds	Others
Methoprene-d₇ is the deuterium labeled Methoprene . Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist .

HY-P1760

Allatostatin IV	Insecticide	Neurological Disease
Allatostatin IV is an octapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-P4989

Type A Allatostatin III	Biochemical Assay Reagents	Infection
Type A Allatostatin III (allatostatin 3) is a blood-brain barrier permeable and reversible neuropeptide that inhibits hormone synthesis in juvenile female cockroaches. Type A Allatostatin III can be used in pesticide research .

HY-B2031S

Pyriproxyfen-d6 S-31183-d₆	Isotope-Labeled Compounds Autophagy Parasite	Infection
Pyriproxyfen-d₆ (S-31183-₆) is the deuterium labeled Pyriproxyfen. Pyriproxyfen is a juvenile hormone analog and insect growth regulator. Pyriproxyfen is used in research related to dengue fever and malaria .

HY-B2031S1

Pyriproxyfen-d4 S-31183-d₄	Isotope-Labeled Compounds Autophagy Parasite	Infection
Pyriproxyfen-d₄ (S-31183-d₄) is the deuterium labeled Pyriproxyfen. Pyriproxyfen is a juvenile hormone analog and insect growth regulator. Pyriproxyfen is used in research related to dengue fever and malaria .

HY-P10390

Insecticidal agent 11	Parasite	Infection
Insecticidal agent 11 (compound Q6) is a potent insect growth regulator (IGR)-based insecticide. Insecticidal agent 11 shows high insecticidal activity against Diploptera punctata by inhibiting juvenile hormone (JH) biosynthesis. Insecticidal agent 11 also exhibits insecticidal activity against Plutella xylostella .

HY-N6703A

(R)-ar-Turmerone (-)-ar-Turmerone	Drug Derivative	Others
(R)-ar-Turmerone is a sesquiterpene ketone that can be found in the sesquiterpene ketone fraction of Curcuma longa L. (R)-ar-Turmerone converts to ar-(+)-juvabione with juvenile hormone activity .

HY-W340857

Farnesane 2,6,10-Trimethyldodecane; Hemisqualane	Biochemical Assay Reagents	Others
Farnesane (2,6,10-Trimethyldodecane; Hemisqualane) is an isoprenoid derivative. Farnesane can be used to modulate juvenile hormone activity in insects .

HY-122940R

Precocene II (Standard) Ageratochromene (Standard)	Others Reference Standards	Metabolic Disease
Precocene II (Standard) is the analytical standard of Precocene II (HY-122940). This product is intended for research and analytical applications. Precocene II (Ageratochromene) is a plant larva hormone antagonists that inhibits the biosynthesis of **juvenile hormone*. Precocene II inhibits corpora allata function and downregulates juvenile* hormone levels, while exerting multiple effects including inducing precocious metamorphosis, forming macropterous morphs, inhibiting ovarian growth, producing cytotoxicity, disrupting insect development, and causing sterility and kidney damage. Precocene II blocks normal nymphal development, causes renal tubular damage and increases blood urea nitrogen levels, and also blocks juvenile hormone biosynthesis in vitro. Precocene II undergoes oxidative metabolism catalyzed by NADPH-dependent monooxygenase to generate a variety of metabolites. Precocene II can be applied in studies related to insect growth regulation and nephrotoxicity .

Cat. No.	Product Name

HY-L040

Anti-diabetic Compound Library	1,113 compounds
Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage. The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes. MCE Anti-diabetic Compound Library owns a unique collection of 1,113 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Anti-diabetic Compound Library

1,113 compounds

Diabetes mellitus, usually called diabetes, is a group of metabolic disorders characterized by a high blood sugar level over a prolonged period of time. The most common types are Type I and Type II. Type I diabetes (T1D), also called juvenile onset diabetes mellitus or insulin-dependent diabetes mellitus, is characterized by destruction of the β-cells of the pancreas and insulin is not produced, whereas type II diabetes (T2D), also called non-insulin-dependent diabetes mellitus, is characterized by a progressive impairment of insulin secretion and relative decreased sensitivity of target tissues to the action of this hormone. Type 2 diabetes accounts for the vast majority of all diabetes mellitus. Diabetes of all types can lead to complications in many parts of the body and can increase the overall risk of dying prematurely. Possible complications include kidney failure, leg amputation, vision loss and nerve damage.

The pathogenesis of diabetes is complicated, and development of the safe and effective drugs against diabetes is full of challenge. Increasing studies have confirmed that the pathogenesis of diabetes is related to various signaling pathways, such as insulin signaling pathway, AMPK pathway, PPAR regulation and chromatin modification pathways. These signaling pathways have thus become the major source of the promising novel drug targets to treat metabolic diseases and diabetes.

MCE Anti-diabetic Compound Library owns a unique collection of 1,113 compounds, which mainly target SGLT, PPAR, DPP-4, AMPK, Dipeptidyl Peptidase, Glucagon Receptor, etc. This library is a useful tool for discovery anti-diabetes drugs.

Cat. No.	Product Name	Target	Research Area

HY-P0060

Tetracosactide Tetracosactrin; ACTH(1–24)	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide (Tetracosactrin) is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P0060A

Tetracosactide acetate Tetracosactrin acetate; ACTH(1–24) acetate	CRFR Melanocortin Receptor	Neurological Disease Inflammation/Immunology
Tetracosactide acetate (Tetracosactrin acetate ) is the acetate salt form of Tetracosactide (HY-P0060). Tetracosactide acetate is an analogue of adrenocorticotrophic hormone (ACTH). Tetracosactide acetate is the agonist for melanocortin-4 receptor (MC4R) that activates human MC4R with an EC₅₀ of 0.65 nM. Tetracosactide acetate can stimulate the release of corticosteroids such as cortisol from the adrenal gland. Tetracosactide acetate is currently used for the research of ulcerative colitis and Crohn's disease, juvenile/adult rheumatoid arthritis and osteoarthrosis .

HY-P1882

Type A Allatostatin I	Insecticide	Inflammation/Immunology
Type A Allatostatin I is a tridecapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-P1786

Allatostatin II	Potassium Channel	Neurological Disease
Allatostatin II is a decapeptid. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-P11196

Allatostatin C AstC	Peptides	Neurological Disease Metabolic Disease
Allatostatin C (AstC) is a neuropeptide that suppresses gonadotropin production. Allatostatin C generates oogenesis rhythm by regulating juvenile hormone and vitellogenesis indirectly via insulin signaling. Allatostatin C can be used for neurological research .

HY-P5866

Allatotropin Manse-AT	Endogenous Metabolite	Endocrinology
Allatotropin (Manse-AT) is a 13 amino acid neuropeptide. Allatotropin activates inositol 1,4,5-trisphosphate (IP3) pathway, and the biosynthesis of juvenile hormone (JH) in Manduca sexta .

HY-P1760

Allatostatin IV	Insecticide	Neurological Disease
Allatostatin IV is an octapeptide. Allatostatins are pleiotropic neuropeptides for inhibition of juvenile hormone synthesis in insects .

HY-P4989

Type A Allatostatin III	Biochemical Assay Reagents	Infection
Type A Allatostatin III (allatostatin 3) is a blood-brain barrier permeable and reversible neuropeptide that inhibits hormone synthesis in juvenile female cockroaches. Type A Allatostatin III can be used in pesticide research .

HY-P10390

Insecticidal agent 11	Parasite	Infection
Insecticidal agent 11 (compound Q6) is a potent insect growth regulator (IGR)-based insecticide. Insecticidal agent 11 shows high insecticidal activity against Diploptera punctata by inhibiting juvenile hormone (JH) biosynthesis. Insecticidal agent 11 also exhibits insecticidal activity against Plutella xylostella .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N7240

*(Rac)-Juvenile* hormone III**	Structural Classification Natural Products Animals Source Classification	Others
(Rac)-Juvenile hormone III is a cecropia juvenile hormone and juvenile hormone agonist. (Rac)-Juvenile hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile hormone III possesses morphogenetic activity in insect assays .

HY-122940

Precocene II Ageratochromene	Structural Classification Natural Products Animals Classification of Application Fields Other Diseases Disease Research Fields Source Classification	Endogenous Metabolite
Precocene II (Ageratochromene) is a plant larva hormone antagonists that inhibits the biosynthesis of **juvenile hormone*. Precocene II inhibits corpora allata function and downregulates juvenile* hormone levels, while exerting multiple effects including inducing precocious metamorphosis, forming macropterous morphs, inhibiting ovarian growth, producing cytotoxicity, disrupting insect development, and causing sterility and kidney damage. Precocene II blocks normal nymphal development, causes renal tubular damage and increases blood urea nitrogen levels, and also blocks juvenile hormone biosynthesis in vitro. Precocene II undergoes oxidative metabolism catalyzed by NADPH-dependent monooxygenase to generate a variety of metabolites. Precocene II can be applied in studies related to insect growth regulation and nephrotoxicity .

HY-122530

Juvocimene I	Natural Products Labiatae Plants Helenium arizonicum S.F.Blake Source Classification	Insecticide
Juvocimene I is a potent juvenile hormone mimic. Juvocimene I can be isolated from the essential oil of sweet basil,Ocimum basilicum L .

HY-N6703A

(R)-ar-Turmerone (-)-ar-Turmerone	Structural Classification Natural Products Plants Curcuma longa Source Classification Zingiberaceae	Drug Derivative
(R)-ar-Turmerone is a sesquiterpene ketone that can be found in the sesquiterpene ketone fraction of Curcuma longa L. (R)-ar-Turmerone converts to ar-(+)-juvabione with juvenile hormone activity .

HY-122940R

Precocene II (Standard) Ageratochromene (Standard)	Structural Classification Natural Products Animals Source Classification	Others Reference Standards
Precocene II (Standard) is the analytical standard of Precocene II (HY-122940). This product is intended for research and analytical applications. Precocene II (Ageratochromene) is a plant larva hormone antagonists that inhibits the biosynthesis of **juvenile hormone*. Precocene II inhibits corpora allata function and downregulates juvenile* hormone levels, while exerting multiple effects including inducing precocious metamorphosis, forming macropterous morphs, inhibiting ovarian growth, producing cytotoxicity, disrupting insect development, and causing sterility and kidney damage. Precocene II blocks normal nymphal development, causes renal tubular damage and increases blood urea nitrogen levels, and also blocks juvenile hormone biosynthesis in vitro. Precocene II undergoes oxidative metabolism catalyzed by NADPH-dependent monooxygenase to generate a variety of metabolites. Precocene II can be applied in studies related to insect growth regulation and nephrotoxicity .

Cat. No.	Product Name	Chemical Structure

HY-N7240S

*(Rac)-Juvenile* Hormone III-d3**
Juvenile Hormone III-d₃ is the deuterium labeled Juvenile Hormone III. (Rac)-Juvenile Hormone III is a cecropia juvenile hormone and juvenile hormone agonist. (Rac)-Juvenile Hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile Hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile Hormone III possesses morphogenetic activity in insect assays .

(Rac)-Juvenile Hormone III-d3

Juvenile Hormone III-d₃ is the deuterium labeled Juvenile Hormone III. (Rac)-Juvenile Hormone III is a cecropia juvenile hormone and juvenile hormone agonist. (Rac)-Juvenile Hormone III induces test insects to retain larval characteristics after the final molt to the adult stage. (Rac)-Juvenile Hormone III exhibits juvenile hormone activity in Tenebrio molitor pupae and last-instar nymphs of Oncopeltus fasciatus. (Rac)-Juvenile Hormone III possesses morphogenetic activity in insect assays .

HY-B1161S

Methoprene-d7
Methoprene-d₇ is the deuterium labeled Methoprene . Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist .

HY-B2031S

Pyriproxyfen-d6
Pyriproxyfen-d₆ (S-31183-₆) is the deuterium labeled Pyriproxyfen. Pyriproxyfen is a juvenile hormone analog and insect growth regulator. Pyriproxyfen is used in research related to dengue fever and malaria .

HY-B2031S1

Pyriproxyfen-d4
Pyriproxyfen-d₄ (S-31183-d₄) is the deuterium labeled Pyriproxyfen. Pyriproxyfen is a juvenile hormone analog and insect growth regulator. Pyriproxyfen is used in research related to dengue fever and malaria .

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juvenile hormone

Inhibitors & Agonists

Screening Libraries

Peptides

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Isotope-Labeled Compounds

Natural
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