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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
7 Results for "
living-mice
" in MedChemExpress (MCE) Product Catalog:
Products (7)
7 Results for "living-mice" in MCE Product Catalog:
Cat. No.: HY-P4154
CAS No.: 2276787-79-0
Synonyms: ALM-488
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Cat. No.: HY-D1065
CAS No.: 1392488-04-8
Cat. No.: HY-D1066
Cat. No.: HY-D3214
CAS No.: 1895099-34-9
Cat. No.: HY-D3442
CAS No.: 3121565-89-4
Research Areas:
ALDH2 probe 5 is a ALDH2 isoform-selective fluorescent probe with an emission wavelength centered at 494 nm. ALDH2 probe 5 is a turn-on fluorescent substrate for ALDH2; in its unreacted aldehyde form, twisted intramolecular charge transfer (TICT) occurs, resulting in fluorescence quenching. After ALDH2 probe 5 is catalytically oxidized to carboxylate by ALDH2, TICT is inhibited and fluorescence is significantly enhanced. ALDH2 probe 5 enables highly sensitive quantitative imaging of ALDH2 activity in recombinant enzymes, live cells, blood, tissue homogenates, and the brains of living mice. ALDH2 probe 5 can be used for studies related to neuroinflammation .
Cat. No.: HY-D3370
CAS No.: 3114128-41-2
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CL-NC is a chemiluminescent probe used for in vivo imaging of N-methyl-D-aspartate receptors (NMDARs), and its detection mechanism relies on bioorthogonal activation achieved via a tetrazine-triggered click-to-release reaction. The isonitrile group of CL-NC undergoes a click reaction with tetrazine, followed by hydrolysis and β-elimination to release a phenoxide anion, which induces the departure of adamantane and generates chemiluminescence. CL-NC has a maximum absorption wavelength of approximately 425 nm, a maximum fluorescence emission wavelength of approximately 670 nm, and a maximum chemiluminescence emission wavelength of 710 nm. When used in combination with Tz-IFDL (HY-D3369), an NMDAR ligand conjugated with tetrazine, CL-NC enables targeted imaging of NMDARs in living cells, as well as in the brain and spinal cord of living mice .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
