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10 Results for "
mast cell chymase
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "mast cell chymase" in MCE Product Catalog:
1
1 Cited Publications
Cat. No.: HY-P4476
CAS No.: 72682-69-0
Target:
Research Areas:
Cathepsin C is a lysosomal cysteine protease essential for catalytic activation of many serine proteases, including proteinase 3 (PR3), neutrophil elastase (NE), cathepsin G (CTSG), granzyme A/B/C, and mast cell chymase .
Cat. No.: HY-122161
CAS No.: 518062-14-1
Synonyms: RWJ-355871
Target:
Research Areas:
JNJ-10311795 (RWJ-355871), a potent dual inhibitor of neutrophil cathepsin G (Ki = 38 nM) and mast cell chymase (Ki = 2.3 nM), exhibits noteworthy antiinflammatory activity .
Cat. No.: HY-100269
CAS No.: 862090-74-2
Target:
Research Areas:
Chymase-IN-1 is a potent, selective, orally active, nonpeptide inhibitor of human mast cell chymase with an IC50 of 29 nM.
Cat. No.: HY-131162
CAS No.: 97501-92-3
Target:
Research Areas:
Chymase is a protein-digester enzyme found primarily in mast cells (MC), fibroblasts, and vascular endothelial cells. Chymase is released into the extracellular stroma in the context of inflammatory signals, tissue injury and cellular stress. Chymase is also involved in angiotensin II (Ang II) production, which is used in cardiovascular disease studies .
Cat. No.: HY-105360
CAS No.: 130370-59-1
Target:
Research Areas:
GI-129471 is a MMP inhibitor. GI-129471 exhibits inhibitory activity against cancer cell invasion. GI-129471 can completely block the enhanced production of IgE and IgG1 by mouse B cells induced by rat mast cell protease-I (RMCP-I). GI-129471 can be used for the study of cancer and mast cell chymase-regulated immunological processes .
Cat. No.: HY-180131
CAS No.: 1312993-34-2
Synonyms: ASB17061
Target:
Research Areas:
INVA8001 (ASB17061) is a highly selective and orally active chymase inhibitor with IC50 values for human chymase and mouse mast cell proteinase 4 (mMCP-4) of 0.02 and 0.03 μM, respectively. INVA8001 exhibits IC50 values for bovine α-chymotrypsin and human cathesin G of 3.4 and 32.1 μM, respectively, and it shows over 1000-fold selectivity for other related serine proteases. INVA8001 inhibits mast cells in a mouse primary sclerosing cholangitis (PSC) model, improves bile duct pathology, and alleviates bile stasis, demonstrating anti-inflammatory and anti-fibrotic effects .
Cat. No.: HY-P72290
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CMA1; chymase; chymase 1; CYH; chymase 1 Preproprotein Transcript E; chymase, mast cell; chymase 1 Preproprotein Transcript I; chymase, Heart; chymase 1, mast cell; MCT1; mast cell Protease I; CYM; Alpha-chymase
Species:
Mouse
Source:
E. coli
Cat. No.: HY-P74252
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: CMA1; chymase; chymase 1; CYH; chymase 1 Preproprotein Transcript E; chymase, mast cell; chymase 1 Preproprotein Transcript I; chymase, Heart; chymase 1, mast cell; MCT1; mast cell Protease I; CYM; Alpha-chymase
Species:
Human
Source:
Sf9 insect cells
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
