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Pathways Recommended:	Immunology/Inflammation

Results for "

microglial inflammation

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (5) Angiotensin-converting Enzyme (ACE) (1) ATP Synthase (1) CD22 (1) CGRP Receptor (1) Chemerin Receptor (1) COX (1) ERK (4) Heme Oxygenase (HO) (1) Interleukin Related (3) Isotope-Labeled Compounds (1) Keap1-Nrf2 (2) mGluR (3) Mitochondrial Metabolism (1) Mitophagy (1) MyD88 (1) NADPH Oxidase (1) NF-κB (7) NO Synthase (1) NOD-like Receptor (NLR) (1) P-selectin (1) p38 MAPK (2) PI3K (1) Reactive Oxygen Species (ROS) (2) Reference Standards (2) Src (1) STAT (1) Syk (1) Tau Protein (1) TGF-β Receptor (1) TNF Receptor (2) Toll-like Receptor (TLR) (1) TREM receptor (1)
By Research Areas:	Cancer (1) Cardiovascular Disease (3) Inflammation/Immunology (15) Metabolic Disease (1) Neurological Disease (9)

By Targets:

Akt (5)

Angiotensin-converting Enzyme (ACE) (1)

ATP Synthase (1)

CD22 (1)

CGRP Receptor (1)

Chemerin Receptor (1)

COX (1)

ERK (4)

Heme Oxygenase (HO) (1)

Interleukin Related (3)

Isotope-Labeled Compounds (1)

Keap1-Nrf2 (2)

mGluR (3)

Mitochondrial Metabolism (1)

Mitophagy (1)

MyD88 (1)

NADPH Oxidase (1)

NF-κB (7)

NO Synthase (1)

NOD-like Receptor (NLR) (1)

P-selectin (1)

p38 MAPK (2)

PI3K (1)

Reactive Oxygen Species (ROS) (2)

Reference Standards (2)

Src (1)

STAT (1)

Syk (1)

Tau Protein (1)

TGF-β Receptor (1)

TNF Receptor (2)

Toll-like Receptor (TLR) (1)

TREM receptor (1)

By Research Areas:

Cancer (1)

Cardiovascular Disease (3)

Inflammation/Immunology (15)

Metabolic Disease (1)

Neurological Disease (9)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W011474

Geranylgeraniol	NF-κB	Inflammation/Immunology
Geranylgeraniol is an orally acitve vitamin K₂ sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-A0183

Phosphatidylserine 1 Publications Verification Phospholipids, phosphatidylserines; Serine glycerophosphatides	Akt TGF-β Receptor	Inflammation/Immunology
Phosphatidylserine (Phospholipids) is a well-conserved anti-inflammatory and immunosuppressive signal. Phosphatidylserine is involved in membrane translocation and the activation of protein kinase C, participating in Akt signaling through its interaction with PIP3. The local exposure of Phosphatidylserine can interact with complement and other proteins, promoting microglial phagocytosis during critical periods of synaptic refinement. Phosphatidylserine can promote blood coagulation in the extracellular environment and acts as a "eat me" signal to clear out apoptotic cells. Phosphatidylserine can suppress inflammation in tissues by inducing TGF-β secretion and inhibiting immune responses .

HY-170621

STAT1/3-IN-1	STAT NO Synthase COX Interleukin Related TNF Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
STAT1/3-IN-1 is a potent STAT1/3 inhibitor with potent anti-inflammatory effect. STAT1/3-IN-1 inhibits phosphorylation and nuclear translocation of STAT1/3 to modulate microglial inflammation, reduces LPS (HY-D1056)-induced pro-inflammatory cytokines (NO, IL-1β, IL-6, and TNF-α) and inflammatory mediators (iNOS, COX-2). STAT1/3-IN-1 exhibits low toxicity in mice. STAT1/3-IN-1 can be used for the research of neuroinflammation .

HY-P99019

Fremanezumab 2 Publications Verification TEV-48125; LBR-101; PF-04427429; RN-307	CGRP Receptor	Neurological Disease Inflammation/Immunology
Fremanezumab (TEV-48125) is a humanized lgG2 monoclonal antibody that selectively and potently binds to calcitonin gene related peptide (CGRp) (IC₅₀ values = 7.943 nM). Fremanezumab binds to mouse CGRP with an IC₅₀ value of 19.6 nM. Fremanezumab counteracts anti-inflammatory effects of CGRP in vitro, including CGRP-mediated inhibition of LPS (HY-D1056)-induced microglial activation. Fremanezumab selectively inhibits the activation of Aδ meningeal nociceptors by cortical spreading depression (CSD) in rats. Fremanezumab can be used for the study of inflammation and chronic migraine .

HY-101364

CHPG 4 Publications Verification	mGluR NF-κB ERK Akt	Cardiovascular Disease Inflammation/Immunology
CHPG is a selective mGluR5 agonist, and attenuates SO₂-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells . CHPG protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways .

HY-P6442

Chemerin15	Chemerin Receptor Syk ERK Src p38 MAPK P-selectin	Cardiovascular Disease Neurological Disease Inflammation/Immunology
Chemerin15 is an anti-inflammatory peptide derived from Chemerin. Chemerin15 binds to ChemR23. Chemerin15 inhibits TNFα-induced activation of Syk, ERK and Src kinases. Chemerin15 increases the expression of p-p38 mRNA and protein. Chemerin15 mediates phagocytosis, resolution of inflammation, CD62L shedding and downregulation of PSGL-1 expression in macrophages and microglia. Chemerin15 inhibits neutrophil-mediated vascular inflammation and myocardial ischemia-reperfusion injury via ChemR23. Chemerin15 enhances microglial phagocytosis, thereby alleviating cerebral ischemia-reperfusion injury .

HY-101364A

CHPG sodium salt 4 Publications Verification	mGluR NF-κB ERK Akt	Neurological Disease Inflammation/Immunology
CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO₂-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells . CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways. .

HY-152026

NADPH oxidase-IN-1	NADPH Oxidase	Neurological Disease
NADPH oxidase-IN-1 is an orally active NADPH oxidase (Nox) inhibitor, related with neuronal inflammation. NADPH oxidase-IN-1 can cross the blood-brain barrier (BBB), inhibits Nox2 and Nox4 with IC₅₀s of 1.9 μM and 2.47 μM, respectively. NADPH oxidase-IN-1 suppresses pro-inflammatory cytokines production and LPS-mediated microglial migration, also has in vivo efficacy .

HY-P990283

Anti-Mouse CD22 Antibody (Cy34.1)	CD22	Neurological Disease Inflammation/Immunology
Anti-Mouse CD22 Antibody (Cy34.1) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse CD22. Anti-Mouse CD22 Antibody (Cy34.1) can deplete CD22 cells and B cells. Anti-Mouse CD22 Antibody (Cy34.1) can promote microglial phagocytosis. Anti-Mouse CD22 Antibody (Cy34.1) can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease (AD) and neuromyelitis .

HY-W011474R

Geranylgeraniol (Standard)	Reference Standards NF-κB	Inflammation/Immunology
Geranylgeraniol (Standard) is the analytical standard of Geranylgeraniol. This product is intended for research and analytical applications. Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model [4].

HY-N9164

Hecubine	TREM receptor Toll-like Receptor (TLR) MyD88 NF-κB Keap1-Nrf2 Heme Oxygenase (HO) TNF Receptor Interleukin Related p38 MAPK PI3K Akt Reactive Oxygen Species (ROS)	Neurological Disease Inflammation/Immunology
Hecubine is a monoterpene indole alkaloid found in Ervatamia ocinalis. Hecubine activates TREM2 expression, reduces LPS (HY-D1056)-stimulated inammatory cytokines (TNF-α、IL-6、IL-1β) overexpression, as well as suppresses the levels of TLR4-, MyD88-, MAPK/PI3K/AKT- and NF-κB-related proteins. Hecubin also exhibits antioxidative effect, reduces ROS production and activates of the Nrf2/HO-1 pathway. Hecubine rescues LPS-induced behavioral deficits in zebrash larvae. Hecubine can be used for the research of neural inflammation-associated central nervous system diseases .

HY-W092110

Phe-Tyr	Angiotensin-converting Enzyme (ACE)	Cardiovascular Disease
Phe-Tyr is an ACE inhibitor. Phe-Tyr can be isolated from wakame. Phe-Tyr exhibits mild concentration-dependent toxicity to fibroblasts. Phe-Tyr can be used in studies related to hypertension and cardiovascular diseases .

HY-W011474S

Geranylgeraniol-d5	Isotope-Labeled Compounds NF-κB	Inflammation/Immunology
Geranylgeraniol-d₅ is the deuterium labeled Geranylgeraniol (HY-W011474). Geranylgeraniol is an orally acitve vitamin K2 sub-type, an intermediate of the mevalonate pathway. Geranylgeraniol targets NF-kB signaling pathway and could alleviate LPS-induced microglial inflammation in animal model .

HY-146168

Nrf2 activator-5	Keap1-Nrf2	Inflammation/Immunology
Nrf2 activator-5 (compound 1) is a potent Nrf2 activator that can attenuate H₂O₂-induced oxidative stress and LPS-stimulated inflammation in BV-2 microglial cells. Nrf2 activator-5 exhibits antioxidant and anti-inflammatory activities .

HY-168091

YM-I-26	NOD-like Receptor (NLR) Interleukin Related	Inflammation/Immunology
YM-I-26 is a selective NLRP3 inflammasome inhibitor. YM-I-26 enhances the phagocytosis of β-amyloid protein by mouse microglial BV2 cells and inhibits the production of IL-1β and IL-10. YM-I-26 can be used to study the immunomodulatory activity associated with inflammation .

HY-101364AR

CHPG sodium salt (Standard)	Reference Standards mGluR NF-κB ERK Akt	Neurological Disease Inflammation/Immunology
CHPG (sodium salt) (Standard) is the analytical standard of CHPG (sodium salt). This product is intended for research and analytical applications. CHPG sodium salt is a selective mGluR5 agonist, and attenuates SO2-induced oxidative stress and inflammation through TSG-6/NF-κB pathway in BV2 microglial cells . CHPG sodium salt protects against traumatic brain injury (TBI) in vitro and in vivo by activation of the ERK and Akt signaling pathways. .

HY-W283930

YHV98-4	Tau Protein ATP Synthase Mitophagy Reactive Oxygen Species (ROS) Mitochondrial Metabolism	Neurological Disease Inflammation/Immunology
YHV98-4 is a selective, blood-brain barrier permeable Hv1 channel inhibitor. YHV98-4 specifically inhibits Hv1 with a half-maximal inhibitory concentration of 1 µM without inhibiting other ion channels. YHV98-4 reduces the propagation of p-tau. YHV98-4 increases ATP production, and enhances microglial mitophagy. YHV98-4 attenuates inflammatory pain via inhibition of Hv1 and ROS production. YHV98-4 enhances microglia-to-neuron mitochondrial transfer, promoting the delivery of functional mitochondria to rescue neuronal damage and improve cognitive function. YHV98-4 reduces inflammation. YHV98-4 can be used in the research of Alzheimer's disease .

Cat. No.	Product Name	Target	Research Area