Anti-Mouse CD22 Antibody (Cy34.1)
Based on 1 Customer Validation
Anti-Mouse CD22 Antibody (Cy34.1) is a mouse-derived IgG1 κ type antibody inhibitor, targeting to mouse CD22. Anti-Mouse CD22 Antibody (Cy34.1) can deplete CD22 cells and B cells. Anti-Mouse CD22 Antibody (Cy34.1) can promote microglial phagocytosis. Anti-Mouse CD22 Antibody (Cy34.1) can be used for the researches of inflammation and neurological disease, such as Alzheimer's disease (AD) and neuromyelitis.
For research use only. We do not sell to patients.
- Purity: 99%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Isotype
Mouse IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Mouse
IC50 & Target
CD22
In Vitro
The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
Anti-Mouse CD22 Antibody (Cy34.1) (1 mg/mL, intracerebrally injection, a single dose) promotes clearance of myelin debris in aged mouse[2].
Anti-Mouse CD22 Antibody (Cy34.1) (1 mg/mL, intracerebrally injection, a single dose) clears injected Aβ oligomers and extracellular α-synuclein fibrils in Aβ-injected aged mouse[2].
Anti-Mouse CD22 Antibody (Cy34.1) (100 μg/mouse, intrastriatally injection, a single dose) depletes CD22-expressing cells and exacerbates NMOSD pathology in neuromyelitis optica spectrum disorder (NMOSD) mice[3].
Anti-Mouse CD22 Antibody (Cy34.1) (10 mg/kg, i.v., three days prior to NMOSD induction) depletes B cells in NMOSD mice[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Neuromyelitis optica spectrum disorder (NMOSD) mice models[1]
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Dosage:100 μg/mouse
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Administration:Intrastriatally injection, a single dose
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Result:Increased the lesion volume.
Augmented the loss of GFAP, AQP4, and MBP expression.
Augmented the inflammatory activity of microglia.
Gene ID
Accession
P35329-1
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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Product Image
Application
in vivo B cell depletion in combination with anti-CD19 (clone 1D3) and anti-rat κ Light Chain (clone
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse CD22 Antibody (Cy34.1)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (262 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Säwén P, et al. Mitotic History Reveals Distinct Stem Cell Populations and Their Contributions to Hematopoiesis. Cell Rep. 2016 Mar 29;14(12):2809-18. [Content Brief]
[2]. Pluvinage JV, et al. CD22 blockade restores homeostatic microglial phagocytosis in ageing brains. Nature. 2019 Apr;568(7751):187-192. [Content Brief]
[3]. Zhang W, et al. CD22 blockade exacerbates neuroinflammation in Neuromyelitis optica spectrum disorder. J Neuroinflammation. 2024 Nov 30;21(1):313. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse CD22 Antibody (Cy34.1) Related Classifications
HY-P990283 Related Classifications
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