Cd22 - CD22 antigen Gene

Also Known as Lyb8; Lyb-8; A530093D23

Species: Mus musculus

Gene Type: protein coding
Gene ID: 12483

Summary

Enables CD4 receptor binding activity; protein Phosphatase binding activity; and sialic acid binding activity. Involved in several processes, including negative regulation of calcium-mediated signaling; negative regulation of immunoglobulin production; and regulation of B cell proliferation. Located in external side of plasma membrane and neuronal cell body membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; liver and biliary system; and reproductive system. Orthologous to human CD22 (CD22 molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd22 Products (2)

mRNA Protein Name
NM_001043317.2 NP_001036782.1 B-cell receptor CD22 precursor
NM_009845.3 NP_033975.3 B-cell receptor CD22 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CD4 receptor binding IPI
IPI: Inferred from physical interaction
12115612 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
9890995 MGI
enables protein phosphatase binding IPI
IPI: Inferred from physical interaction
12115612 MGI
enables sialic acid binding IPI
IPI: Inferred from physical interaction
12115612 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of calcium-mediated signaling IGI
IGI: Inferred from genetic interaction
20200274 MGI
involved in negative regulation of immunoglobulin production IGI
IGI: Inferred from genetic interaction
20200274 MGI
involved in regulation of B cell proliferation IGI
IGI: Inferred from genetic interaction
20200274 MGI
involved in regulation of immune response IGI
IGI: Inferred from genetic interaction
20200274 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
15095367 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
8418208 MGI
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
15095367 MGI
located in plasma membrane IPI
IPI: Inferred from physical interaction
11606382 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

B-cell receptor CD22

  • B-lymphocyte cell adhesion molecule

  • BL-CAM

  • T-cell surface antigen Leu-14

  • sialic acid-binding Ig-like lectin 2

  • siglec-2

Recombinant Cd22 Proteins

Cat. No. Product Name Accession Purity
HY-P72474 Siglec-2/CD22 Protein, Mouse (AAA02562.1, HEK293, His) AAA02562.1 (S22-R702) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73646 Siglec-2/CD22 Protein, Mouse (HEK293, Fc) BAE33829 (R19-R708) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P72474A Siglec-2/CD22 Protein, Mouse (HEK293, His) P35329-1 (S22-P702) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P9959 Inotuzumab ozogamicin Inhibitor 99.7% Unkown

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-141602 Pinatuzumab vedotin Inhibitor / Phase 2
Inhibitory Antibodies (6)
Cat. No. Product Name Effect
Purity Phase
HY-P99264 Inotuzumab Inhibitor 96.19 Phase 4
HY-P99289 Epratuzumab 99.53% Phase 3
HY-P99034 Moxetumomab Inhibitor 99.77% Phase 3
HY-P990781 Suciraslimab Inhibitor 97.42% Phase 3
HY-P99230 Pinatuzumab Inhibitor 99.70% Phase 2
HY-P990759 Rezetamig Inhibitor 95.65% Phase 1

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-146081 CD22 ligand-1 / Unkown
HY-171172 GSC-718 Inhibitor / Unkown
HY-185659 6'-BPANeuGc Ligand / Unkown
HY-P9959A Inotuzumab ozogamicin (solution) Inhibitor / Unkown
Inhibitory Antibodies (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990283 Anti-Mouse CD22 Antibody (Cy34.1) Inhibitor 99% Unkown
HY-P990930 Mozistobart 99.21% Unkown
HY-P991550 RFB4 Inhibitor 96.93% Unkown
HY-P991906 TRPH-222 Antibody / Unkown
HY-P99264A Inotuzumab (powder) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd22 NCBI NCBI:933