2. Antibody-drug Conjugate/ADC Related Immunology/Inflammation
  3. Antibody-Drug Conjugates (ADCs) CD22
  4. Inotuzumab ozogamicin (solution)

Inotuzumab ozogamicin (solution)  (Synonyms: CMC-544 (solution); PF-5208773 (solution); WAY-207294 (solution))

Cat. No.: HY-P9959A
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Inotuzumab ozogamicin solution (CMC-544 solution) is an antibody-targeted chemotherapy agent composed of a humanized anti-CD22 antibody conjugated to Calicheamicin (HY-19609). Inotuzumab ozogamicin solution and G544 bind human CD22 with similar affinities (Kd ≈ 150 pM). Inotuzumab ozogamicin solution has demonstrated efficacy against CD22+ B-cell non-Hodgkin’s lymphoma. Inotuzumab ozogamicin solution can be used in the research of acute lymphoblastic leukemia.

For research use only. We do not sell to patients.

Inotuzumab ozogamicin (solution)

Inotuzumab ozogamicin (solution) Chemical Structure

CAS No. : 635715-01-4

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Description

Inotuzumab ozogamicin solution (CMC-544 solution) is an antibody-targeted chemotherapy agent composed of a humanized anti-CD22 antibody conjugated to Calicheamicin (HY-19609). Inotuzumab ozogamicin solution and G544 bind human CD22 with similar affinities (Kd ≈ 150 pM). Inotuzumab ozogamicin solution has demonstrated efficacy against CD22+ B-cell non-Hodgkin’s lymphoma. Inotuzumab ozogamicin solution can be used in the research of acute lymphoblastic leukemia[1][2][3].

In Vitro

Inotuzumab ozogamicin solution exerts highly potent cytotoxic activity against a vari-
ety of CD22-positive B-cell origin cancer cell lines[1].
Inotuzumab ozogamicin solution and G544
bind human CD22 with similar affinities (KD ≈ 150 pM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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In Vivo

Inotuzumab ozogamicin solution causes dose-dependent regression of B-lymphoma xenografts grown as subcutaneous solid tumors in athymic nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
CAS No.
SMILES

[Inotuzumab ozogamicin (solution)]
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Purity & Documentation
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Inotuzumab ozogamicin (solution) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Inotuzumab ozogamicin (solution)635715-01-4CMC-544 (solution) PF-5208773 (solution) WAY-207294 (solution)Antibody-Drug Conjugates (ADCs)CD22Antibody-Drug ConjugatesSiglec 2B-cell malignancy modelsdiffuse large B-cell lymphomanon-Hodgkin’s lymphomaapoptosiscalicheamicinDNA double-strand breaksB-cellfollicular lymphomaacute lymphocytic leukemiaInhibitorinhibitorinhibit

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