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Cat. No.: HY-171172

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GSC-718

GSC-718 is a CD22 inhibitor with an IC₅₀ of 0.161 μM against mouse CD22. GSC-718 competitively blocks the binding of mouse CD22 to natural glycan ligands, and inhibits the interaction between CD22 and α2,6-sialylated ligands. GSC-718 promotes B cell proliferation and enhances antibody production. GSC-718 can be used in the research of B cell lymphoma and rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No.: 2493080-16-1
Formula: C₃₂H₃₅N₂NaO₁₁
Molecular Weight:646.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

GSC-718 Chemical Structure

CAS No.: 2493080-16-1

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Use of MCE Products

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Biological Activity

Description

In Vitro

GSC-718 (2 hours) potently inhibits recombinant mouse CD22-Fc binding to biotinylated sialoside 71 in a competitive ELISA with an IC₅₀ of 0.161 µM^[1].
GSC-718 significantly enhances B cell proliferation induced by various stimuli including toll-like receptor ligands^[1].
GSC-718 (10-100 μM; 10 min) partially inhibits proximity labeling of CD22-associated proteins on wild-type mouse spleen B cells, while GSC-932 achieves near-complete inhibition under the same conditions^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2493080-16-1
Molecular Weight 646.62
Formula C₃₂H₃₅N₂NaO₁₁
SMILES

O=C(O[Na])[C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(CO)=O)([H])[C@H](O)[C@H](O)CNC(CC2=CC=C(C3=CC=C(C=C3)O)C=C2)=O)OCC4=CC=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Suganuma Y, et al. Improved synthesis of CD22-binding sialosides and its application for further development of potent CD22 inhibitors. Glycoconjugate journal. 2023 Apr;40(2):225-246. [Content Brief]

[2]. Alborzian Deh Sheikh A, et al. Analysis of CD22 cis-ligands using a synthetic sialoside binding to CD22 with ultra-high affinity. Carbohydrate research. 2025 Aug;554:109519.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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