2493080-16-1
2493080-16-1
Chemical Structure
GSC-718
- CAS No.: 2493080-16-1
- Formula:C32H35N2NaO11
- Molecular Weight:646.62
InChIKey: BRWKDZYDGXKLQA-ZJKDNQKCSA-M
SMILES: O=C(O[Na])[C@@]1(O[C@@]([C@@H]([C@H](C1)O)NC(CO)=O)([H])[C@H](O)[C@H](O)CNC(CC2=CC=C(C3=CC=C(C=C3)O)C=C2)=O)OCC4=CC=CC=C4
Biological Activity: GSC-718 is a CD22 inhibitor with an IC50 of 0.161 μM against mouse CD22. GSC-718 competitively blocks the binding of mouse CD22 to natural glycan ligands, and inhibits the interaction between CD22 and α2,6-sialylated ligands. GSC-718 promotes B cell proliferation and enhances antibody production. GSC-718 can be used in the research of B cell lymphoma and rheumatoid arthritis[1][2].
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GSC-718 | GSC-718 is a CD22 inhibitor with an IC50 of 0.161 μM against mouse CD22. GSC-718 competitively blocks the binding of mouse CD22 to natural glycan ligands, and inhibits the interaction between CD22 and α2,6-sialylated ligands. GSC-718 promotes B cell proliferation and enhances antibody production. GSC-718 can be used in the research of B cell lymphoma and rheumatoid arthritis. | |||||||||||||||||||||
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References
- [1]. Suganuma Y, et al. Improved synthesis of CD22-binding sialosides and its application for further development of potent CD22 inhibitors. Glycoconjugate journal. 2023 Apr;40(2):225-246. [Content Brief]
- [2]. Alborzian Deh Sheikh A, et al. Analysis of CD22 cis-ligands using a synthetic sialoside binding to CD22 with ultra-high affinity. Carbohydrate research. 2025 Aug;554:109519.
