6'-BPANeuGc 

6'-BPANeuGc is a CD22-targeting ligand. 6'-BPANeuGc suppresses BCR activation, recruits CD22 to B cell immunological synapses, initiates inhibitory signals, induces B cell apoptosis. 6'-BPANeuGc inhibits calcium flux, and inhibits Akt and Erk activation. 6'-BPANeuGc can be used for research on immune system diseases^[1][2].

6'-BPANeuGc (1-4%; 40 min) is a selective ligand for CD22^[1].
6'-BPANeuGc (1-4%) suppresses BCR-mediated calcium flux in murine peritoneal B1a cells and splenic B2 cells in a CD22-dependent manner^[1].
6'-BPANeuGc (1 μM) reconstitutes ligand-deficient Per-mHEL B cells to strongly inhibit activation of WT IgMHEL B cells^[2].
6'-BPANeuGc, when presented on antigenic liposomes, inhibits calcium flux in WT mouse B cells in a CD22- and Lyn-dependent manner^[2].
6'-BPANeuGc (3 min), when presented on antigenic liposomes, inhibits Akt and Erk phosphorylation in WT IgMHEL B cells in a Lyn-dependent manner^[2].
6'-BPANeuGc (24 h), when presented on HEL-displaying liposomes, induces apoptosis of WT IgMHEL B cells in a CD22-, BIM-, and Lyn-dependent manner^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

6'-BPANeuGc (i.p.; single dose), when presented on liposomes, alongside anti-IgM suppress BCR activation in both B1a and B2 B cells in a CD22-dependent manner in wild-type C57BL/6J mice^[1].
6'-BPANeuGc (i.v.) induces CD22-, BIM-, and Lyn-dependent depletion of antigen-reactive wild-type IgM^HEL B cells in vivo, reducing the population to 0.016% of CD19⁺CD45.1⁺ cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

926.91

C₄₁H₅₈N₄O₂₀

1596134-78-9

OC[C@@H](O[C@H]([C@@H]([C@H]1O)NC(C)=O)OCCN)[C@H]1O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)O[C@@H]2CO[C@]3(O[C@@]([C@@H]([C@H](C3)O)NC(CO)=O)([H])[C@H](O)[C@H](O)CNC(CC4=CC=C(C5=CC=CC=C5)C=C4)=O)C(O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Pfrengle F, et al. Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22. J Immunol. 2013 Aug 15;191(4):1724-31.

  [2]. Macauley MS, et al. Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells. J Immunol. 2014;193(9):4312-4321.