6'-BPANeuGc
6'-BPANeuGc is a CD22-targeting ligand. 6'-BPANeuGc suppresses BCR activation, recruits CD22 to B cell immunological synapses, initiates inhibitory signals, induces B cell apoptosis. 6'-BPANeuGc inhibits calcium flux, and inhibits Akt and Erk activation. 6'-BPANeuGc can be used for research on immune system diseases.
For research use only. We do not sell to patients.
- CAS No.: 1596134-78-9
- Formula: C41H58N4O20
- Molecular Weight:926.91
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
6'-BPANeuGc (1-4%; 40 min) is a selective ligand for CD22[1].
6'-BPANeuGc (1-4%) suppresses BCR-mediated calcium flux in murine peritoneal B1a cells and splenic B2 cells in a CD22-dependent manner[1].
6'-BPANeuGc (1 μM) reconstitutes ligand-deficient Per-mHEL B cells to strongly inhibit activation of WT IgMHEL B cells[2].
6'-BPANeuGc, when presented on antigenic liposomes, inhibits calcium flux in WT mouse B cells in a CD22- and Lyn-dependent manner[2].
6'-BPANeuGc (3 min), when presented on antigenic liposomes, inhibits Akt and Erk phosphorylation in WT IgMHEL B cells in a Lyn-dependent manner[2].
6'-BPANeuGc (24 h), when presented on HEL-displaying liposomes, induces apoptosis of WT IgMHEL B cells in a CD22-, BIM-, and Lyn-dependent manner[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
6'-BPANeuGc (i.v.) induces CD22-, BIM-, and Lyn-dependent depletion of antigen-reactive wild-type IgMHEL B cells in vivo, reducing the population to 0.016% of CD19+CD45.1+ cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1596134-78-9
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Molecular Weight 926.91
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Formula C41H58N4O20
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SMILES
OC[C@@H](O[C@H]([C@@H]([C@H]1O)NC(C)=O)OCCN)[C@H]1O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)O[C@@H]2CO[C@]3(O[C@@]([C@@H]([C@H](C3)O)NC(CO)=O)([H])[C@H](O)[C@H](O)CNC(CC4=CC=C(C5=CC=CC=C5)C=C4)=O)C(O)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Pfrengle F, et al. Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22. J Immunol. 2013 Aug 15;191(4):1724-31. [Content Brief]
[2]. Macauley MS, et al. Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells. J Immunol. 2014;193(9):4312-4321. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
6'-BPANeuGc Related Classifications
HY-185659 Related Classifications
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