1596134-78-9
Chemical Structure
6'-BPANeuGc
- CAS No.: 1596134-78-9
- Formula:C41H58N4O20
- Molecular Weight:926.91
InChIKey: SWUIIBZKNVRPIT-SYGQXULASA-N
SMILES: OC[C@@H](O[C@H]([C@@H]([C@H]1O)NC(C)=O)OCCN)[C@H]1O[C@@H]([C@@H]([C@H]([C@H]2O)O)O)O[C@@H]2CO[C@]3(O[C@@]([C@@H]([C@H](C3)O)NC(CO)=O)([H])[C@H](O)[C@H](O)CNC(CC4=CC=C(C5=CC=CC=C5)C=C4)=O)C(O)=O
Biological Activity: 6'-BPANeuGc is a CD22-targeting ligand. 6'-BPANeuGc suppresses BCR activation, recruits CD22 to B cell immunological synapses, initiates inhibitory signals, induces B cell apoptosis. 6'-BPANeuGc inhibits calcium flux, and inhibits Akt and Erk activation. 6'-BPANeuGc can be used for research on immune system diseases[1][2].
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6'-BPANeuGc | 6'-BPANeuGc is a CD22-targeting ligand. 6'-BPANeuGc suppresses BCR activation, recruits CD22 to B cell immunological synapses, initiates inhibitory signals, induces B cell apoptosis. 6'-BPANeuGc inhibits calcium flux, and inhibits Akt and Erk activation. 6'-BPANeuGc can be used for research on immune system diseases. | |||||||||||||||||||||
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- [1]. Pfrengle F, et al. Copresentation of antigen and ligands of Siglec-G induces B cell tolerance independent of CD22. J Immunol. 2013 Aug 15;191(4):1724-31. [Content Brief]
- [2]. Macauley MS, et al. Siglecs induce tolerance to cell surface antigens by BIM-dependent deletion of the antigen-reactive B cells. J Immunol. 2014;193(9):4312-4321. [Content Brief]
Keywords
