32607-79-7
Chemical Structure
Glutathione trisulfide
Synonym(s): GSSSG
- CAS No.: 32607-79-7
- Formula:C20H32N6O12S3
- Molecular Weight:644.69
IUPAC Name: (2S,2'S)-5,5'-(((2R,2'R)-trisulfanediylbis(3-((carboxymethyl)amino)-3-oxopropane-1,2-diyl))bis(azanediyl))bis(2-amino-5-oxopentanoic acid)
InChIKey: FQEIPOORDCCMGQ-BJDJZHNGSA-N
SMILES: [C@@H](NC(CC[C@@H](C(O)=O)N)=O)(C(NCC(O)=O)=O)CSSSC[C@H](NC(CC[C@@H](C(O)=O)N)=O)C(NCC(O)=O)=O
Biological Activity: Glutathione trisulfide (GSSSG) is a potent neuroprotective agent with anti-inflammatory activity. Glutathione trisulfide prevents the LPS (HY-D1056)-induced inflammatory gene expression in retinal pigment epithelial cells, which is mediated through hyperactivation of ERK signaling, independent of the NRF2/HMOX1 pathway. Glutathione trisulfide can be used for neurodegenerative diseases and ischemic spinal cord injury (SCI) research[1][2].
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Glutathione trisulfide | Glutathione trisulfide (GSSSG) is a potent neuroprotective agent with anti-inflammatory activity. Glutathione trisulfide prevents the LPS (HY-D1056)-induced inflammatory gene expression in retinal pigment epithelial cells, which is mediated through hyperactivation of ERK signaling, independent of the NRF2/HMOX1 pathway. Glutathione trisulfide can be used for neurodegenerative diseases and ischemic spinal cord injury (SCI) research. | |||||||||||||||||||||
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- [1]. Tawarayama H, et al. Glutathione Trisulfide Prevents Lipopolysaccharide-induced Inflammatory Gene Expression in Retinal Pigment Epithelial Cells. Ocul Immunol Inflamm. 2022 May 19;30(4):789-800. [Content Brief]
- [2]. Fumito Ichinose, et al. Glutathione trisulfide (gsssg) in neuroprotection. WO2021231476A1. 2021-11-18.
Keywords
