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mitochondria-mediated apoptotic pathway

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Apoptosis (3) Bacterial (1) Bcl-2 Family (1) Caspase (1) ClpP (2) E1/E2/E3 Enzyme (2) Fungal (1) MMP (2) p38 MAPK (1) Reactive Oxygen Species (ROS) (1) Reference Standards (1)
By Research Areas:	Cancer (4) Infection (3) Inflammation/Immunology (3)

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Targets Recommended: Tissue Factor Pathway Inhibitor (TFPI)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N2360

Hinokiflavone 5+ Cited Publications	E1/E2/E3 Enzyme Apoptosis MMP ClpP	Infection Inflammation/Immunology Cancer
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC₅₀ value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

HY-P2853

Hemocyanin	p38 MAPK Reactive Oxygen Species (ROS) Bacterial Fungal	Infection Inflammation/Immunology Cancer
Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth .

HY-147929

Apoptotic agent-3	Apoptosis Caspase Bcl-2 Family	Cancer
Apoptotic agent-3 (compound 15f) promotes apoptosis through the potential mitochondria-mediated Bcl-2/Bax pathway and activation of the Caspase 3 pathway. Apoptotic agent-3 exhibits anti-proliferative activities and can be used for cancer research .

HY-N2360R

Hinokiflavone (Standard)	Reference Standards E1/E2/E3 Enzyme Apoptosis MMP ClpP	Infection Inflammation/Immunology Cancer
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

Cat. No.	Product Name	Type

HY-P2853

Hemocyanin	Biochemical Assay Reagents
Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth .

Hemocyanin

Biochemical Assay Reagents

Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N2360

Hinokiflavone 5+ Cited Publications	Flavonoids Classification of Application Fields Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Disease Research Fields Source Classification Cancer	E1/E2/E3 Enzyme Apoptosis MMP ClpP
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC₅₀ value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

HY-P2853

Hemocyanin	Structural Classification Natural Products Animals Source Classification	p38 MAPK Reactive Oxygen Species (ROS) Bacterial Fungal
Hemocyanin is an extracellular giant copper-containing glycoprotein. Hemocyanin can be found in the hemolymph of both mollusk and arthropod. Hemocyanin is responsible for oxygen transport. Hemocyanin is also involved in several physiological processes, such as energy storage, osmoregulation, molt cycle and exoskeleton formation. Hemocyanin in shrimp can enhance its immune response by modulating the p38 MAPK pathway. Hemocyanin from Penaeus monodon could act as an antiviral agent against a variety of viruses including DNA and RNA viruses. Hemocyanin from horseshoe crab Carcinoscorpius rotundicauda could possess a strong antimicrobial defense by the production of ROS activated with microbial proteases. Hemocyanin from L. vannamei would be effective against cervical cancer cell growth .

HY-N2360R

Hinokiflavone (Standard)	Structural Classification Flavonoids Phenols Polyphenols Selaginellaceae Plants Biflavones Selaginella tamariscina (P. Beauv.) Spring Source Classification	Reference Standards E1/E2/E3 Enzyme Apoptosis MMP ClpP
Hinokiflavone is a novel modulator of pre-mRNA splicing activity extracted from plants with anti-inflammatory, anti-tumor and antiviral activities. Hinokiflavone is also a potent inhibitor for matrix metalloproteinases (MMPs). Hinokiflavone attenuates the virulence of Methicillin (HY-121544)-resistant staphylococcus aureus by inhibiting caseinolytic protease P (ClpP) with an IC50 value of 34.36 mg/mL. Hinokiflavone induces apoptosis via the reactive oxygen species-mitochondria-mediated apoptotic pathway and inhibits tumor cell migration and invasion. Hinokiflavone is a SUMO protease inhibitor against sentrin-specific protease 1 (SENP1) activity .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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mitochondria-mediated apoptotic pathway

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